Co-encapsulation of chlorogenic acid and cinnamaldehyde essential oil in Pickering emulsion stablized by chitosan nanoparticles

Niu, Ben; Chen, Hangjun; Wu, Wei; Fang, Xiangjun; Mu, Honglei; Han, Yanchao; Gao, Haiyan

doi:10.1016/j.fochx.2022.100312

Cited by 24 publications

(9 citation statements)

References 33 publications

(31 reference statements)

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“…The PDI value of CAR/CS NPs was found to be 0.221 that indicated narrow and uniform particle size distribution. This result correlated with the previous study, where the cinnamaldehyde CS/NP PDI value between 0.23 and 0.29 was observed and indicated uniformed particle size distribution . The successful loading of CAR reduced the ZP of CS/NPs and also ensured stability of NPs with no aggregation.…”

Section: Discussionsupporting

confidence: 92%

Carvacrol-Fabricated Chitosan Nanoparticle Synergistic Potential with Topoisomerase Inhibitors on Breast and Cervical Cancer Cells

Akhlaq,

Ashraf,

Omer

et al. 2023

ACS Omega

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Breast and cervical cancers are the most common heterogeneous malignancies in women. Chemotherapy with conventional drug delivery systems having several limitations along with development of multidrug resistance compelled us to seek out targeted therapeutics. Nanoparticles are suitable substitutes to circumvent multidrug resistance for the targeted treatment of cancer. The current study was aimed to investigate the anticancer effect of carvacrolloaded chitosan nanoparticles with topoisomerase inhibitors. The average size of carvacrol-loaded chitosan nanoparticles was found to be 80 nm with 24.7 mV ζpotential, and maximum absorbance was observed at 275 nm. Among all drug combinations, the carvacrol nanoparticles with the doxorubicin combination group exerted greater dose-dependent growth inhibition of both MCF-7 and HeLa cells as compared to single carvacrol nanoparticles and doxorubicin. Combination index values of carvacrol nanoparticles and the doxorubicin combination group showed a strong synergistic effect as they were found to be between 0.2 and 0.4, 0.31 for MCF-7 and 0.34 for HeLa cells. The carvacrol nanoparticles in combination with doxorubicin on MCF-7 cells reduced the dose 16.32-fold for carvacrol nanoparticles and 4.09-fold for doxorubicin at 6.23 μg/mL IC 50 , while on HeLa cells, this combination reduced the dose 13.18-fold for carvacrol nanoparticles and 3.83-fold for doxorubicin at 9.33 μg/mL IC 50 . As the dose reduction values were greater than 1, they indicated favorable dose reduction. It was concluded that the combination of carvacrol-loaded chitosan nanoparticles with topoisomerase inhibitors may represent an innovative and promising strategy to improve the efficacy, resistance, and targeted delivery of chemotherapeutics in cancer.

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Section: Discussionsupporting

confidence: 92%

Carvacrol-Fabricated Chitosan Nanoparticle Synergistic Potential with Topoisomerase Inhibitors on Breast and Cervical Cancer Cells

Akhlaq,

Ashraf,

Omer

et al. 2023

ACS Omega

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“…Particle with smaller size and lower viscosity meant less hindrance during homogenization, making it easier to adsorb on the droplet surface and reduce the droplet size. In addition, the adsorption time for the larger particles at the interface is longer, leading to larger droplet size of emulsions 32 . Enzymatic hydrolysis altered the wettability and further reduced the particle size and viscosity of ISF, contributing to the smaller droplet size of hydrolyzed‐ISF stabilized emulsions 29 …”

Section: Resultsmentioning

confidence: 99%

“…In addition, the adsorption time for the larger particles at the interface is longer, leading to larger droplet size of emulsions. 32 Enzymatic hydrolysis altered the wettability and further reduced the particle size and viscosity of ISF, contributing to the smaller droplet size of hydrolyzed-ISF stabilized emulsions. 29…”

Section: Particle Size Distributionmentioning

confidence: 99%

Effects of physical method and enzymatic hydrolysis on the properties of soybean fiber‐rich stabilizer for oil in water emulsions

Huang,

Cai,

Zhao

et al. 2023

J Sci Food Agric

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BACKGROUNDOkara is a by‐product from the soybean industry and an abundant resource of insoluble soybean fiber (ISF). ISF with various properties could be obtained by different extraction methods. It is an attractive option to utilize okara by taking advantage of ISF as an emulsifier or stabilizer.RESULTSCompared with the untreated ISF (ISFUT), superfine grinding reduced the particle size and viscosity of ISF (ISFSG). Steam explosion increased the water solubility from 17.5% to 51.7% but decreased the water holding capacity and swelling capacity of ISF (ISFSE) from 15.0 and 14.0 g/g to 4.2 and 3.3 g/g, respectively. Emulsions prepared by ISFUT and ISFSG before or after enzymatic hydrolysis presented large oil droplets and were unstable. Although emulsions prepared by ISFSE after enzymatic hydrolysis (ISFSE‐E) showed flocculation, the volume‐weighted average diameter (19.7 μm) were the smallest while the viscosity and viscoelastic modulus were the highest, and exhibited excellent physical stability during storage.CONCLUSIONISF obtained by physical and hydrolysis treatment displayed diverging physicochemical properties while ISF prepared by steam explosion‐enzymatic hydrolysis presented the best potential to stabilize emulsions. The present study could provide novel information about the utilization of okara by the application of ISF as an emulsifier or stabilizer. © 2023 Society of Chemical Industry.

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“…Moreover, when the CS to CGA ratio is 1 : 0.75, the emulsion's stability is optimal after 5 days, with the minimum emulsification index recorded at 26.5 ± 4.6%. 112 Additionally, Chen et al developed a self-microemulsifying drug delivery system for CGA, subjecting it to comprehensive characterization encompassing the self-emulsification rate, morphological observation, droplet size determination, stability, in vitro release, in vivo bioavailability, and tissue distribution experiments. The results demonstrate that the self-microemulsifying drug delivery system for CGA achieves a self-emulsification rate surpassing 98%, with a microemulsion droplet size of 16.37 nm, exceptional stability, and a marked enhancement in the bioavailability of CGA (249.4% relative to CGA suspension).…”

Section: Nutrient Delivery System Incorporating Cgamentioning

confidence: 99%

Unleashing the power of chlorogenic acid: exploring its potential in nutrition delivery and the food industry

Hu,

Zhao,

Chi

et al. 2024

Food Funct.

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Co-encapsulation of chlorogenic acid and cinnamaldehyde essential oil in Pickering emulsion stablized by chitosan nanoparticles

Cited by 24 publications

References 33 publications

Carvacrol-Fabricated Chitosan Nanoparticle Synergistic Potential with Topoisomerase Inhibitors on Breast and Cervical Cancer Cells

Carvacrol-Fabricated Chitosan Nanoparticle Synergistic Potential with Topoisomerase Inhibitors on Breast and Cervical Cancer Cells

Effects of physical method and enzymatic hydrolysis on the properties of soybean fiber‐rich stabilizer for oil in water emulsions

Unleashing the power of chlorogenic acid: exploring its potential in nutrition delivery and the food industry

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