Co-electrospun blends of PU and PEG as potential biocompatible scaffolds for small-diameter vascular tissue engineering

Wang, Heyun; Feng, Yakai; Fang, Zhiwei; Yuan, Wenjie; Khan, Musammir

doi:10.1016/j.msec.2012.07.001

Cited by 117 publications

(109 citation statements)

References 40 publications

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“…It is worth investigating the cellular response to electrospun TPU scaffolds with different wettability characteristics since, to the best of our knowledge, no studies have been done on this to date. Yuan and coworkers 24 reported on a PU/polyethylene glycol vascular scaffold with improved hydrophilicity that proved suitable for endothelia cells attachment and proliferation. Kim et al 25 showed that hydrophilicity can be improved by adding gelatin into TPU, with the resulting scaffolds displaying better cell proliferation.…”

Section: Introductionmentioning

confidence: 99%

Properties and fibroblast cellular response of soft and hard thermoplastic polyurethane electrospun nanofibrous scaffolds

Jing

Salick

et al. 2014

J Biomed Mater Res

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Soft and hard thermoplastic polyurethane (TPU) and their blends were electrospun to fabricate nanofibrous scaffolds with various properties in order to investigate the substrate property effects on cellular response. The scaffolds were characterized with Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy, water contact angle tests, and protein absorption tests. It was found that the hard segment content in the scaffold increased with the hard TPU ratio, which resulted in improved hydrophobicity and decreased over all protein absorption. 3T3 fibroblasts were cultured on those scaffolds to investigate the cellular response. On soft TPU scaffolds, the cells formed were round in shape and aggregated into clusters. However, on hard TPU scaffolds, the cells exhibited a spindle shape and spread out on the scaffolds, indicating preferred cell-substrate interaction. The cell viability and proliferation of cells on hard scaffolds were higher than on soft scaffolds and on 50% hard/50% soft scaffolds.

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Section: Introductionmentioning

confidence: 99%

Properties and fibroblast cellular response of soft and hard thermoplastic polyurethane electrospun nanofibrous scaffolds

Jing

Salick

et al. 2014

J Biomed Mater Res

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“…Small caliber vascular grafts (diameter < 4 mm) are so far associated with an increased risk of thrombosis and occlusion. [4][5][6] Therefore, strategies for improving their compliance and hemocompatibility are demanded. One option gaining hemocompatibility is the functionalization of the inner surface with the aim to minimize protein adsorption and to hinder thrombocytes to adhere.…”

mentioning

confidence: 99%

Nanoparticles Complexed with Gene Vectors to Promote Proliferation of Human Vascular Endothelial Cells

Shi

Zhang

et al. 2015

Adv Healthcare Materials

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Amphiphilic block copolymers containing biodegradable hydrophobic segments of depsipeptide based copolymers have been synthesized and explored as gene carriers for enhancing proliferation of endothelial cells in vitro. These polymers form nanoparticles (NPs) with positive charges on their surface, which could condense recombinant plasmids of enhanced green fluorescent protein plasmid and ZNF580 gene (pEGFP-ZNF580) and protect them against DNase I. ZNF580 gene is efficiently transported into EA.hy926 cells to promote their proliferation, whereby the transfection efficiency of NPs/pEGFP-ZNF580 is approximately similar to that of Lipofectamine 2000. These results indicate that the NPs might have potential as a carrier for pEGFP-ZNF580, which could support endothelialization of cardiovascular implants.

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“…4,5 For example, silk fiber, collagen, heparin, poly(ethylene glycol), gelatin, zwitterionic polynorbornene and 2-methacryloyloxyethyl phosphorylcholine have been widely used in surface modification of artificial blood scaffolds. [6][7][8][9][10][11][12][13][14] The hydrophilicity, hemocompatibility and biocompatibility of artificial blood vessels have been improved greatly after surface modification.…”

Section: Introductionmentioning

confidence: 99%

Co-self-assembly of cationic microparticles to deliver pEGFP-ZNF580 for promoting the transfection and migration of endothelial cells

Feng¹,

Guo²,

Li³

et al. 2016

IJN

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Co-electrospun blends of PU and PEG as potential biocompatible scaffolds for small-diameter vascular tissue engineering

Cited by 117 publications

References 40 publications

Properties and fibroblast cellular response of soft and hard thermoplastic polyurethane electrospun nanofibrous scaffolds

Properties and fibroblast cellular response of soft and hard thermoplastic polyurethane electrospun nanofibrous scaffolds

Nanoparticles Complexed with Gene Vectors to Promote Proliferation of Human Vascular Endothelial Cells

Co-self-assembly of cationic microparticles to deliver pEGFP-ZNF580 for promoting the transfection and migration of endothelial cells

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