Co-deposition of salmeterol and fluticasone propionate by a combination inhaler☆

Theophilus, Andrew; Moore, Alison; Prime, Dave; Rossomanno, Simona; Whitcher, Brandon; Chrystyn, Henry

doi:10.1016/j.ijpharm.2006.01.018

Cited by 47 publications

(26 citation statements)

References 24 publications

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“…Salmeterol xinafoate-fluticasone propionate formulations are, in contrast, governed by a more complex mechanism including non-specified chemical interactions. Previous research on combined salmeterol xinafoate and fluticasone propionate formulations already indicated the presence of interactions depending on the physical and chemical nature of the particles and the media (Michael et al, 2000(Michael et al, , 2001Theophilus et al, 2006). The exact nature of these interactions has not yet been specified.…”

Section: Adhesion Measurementsmentioning

confidence: 99%

Characterisation of dry powder inhaler formulations using atomic force microscopy

Weiss

McLoughlin

Cathcart

2015

International Journal of Pharmaceutics

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A B S T R A C TInhalation formulations are a popular way of treating the symptoms of respiratory diseases. The active pharmaceutical ingredient (API) is delivered directly to the site of action within the deep lung using an inhalation device such as the dry powder inhaler (DPI).The performance of the formulation and the efficiency of the treatment depend on a number of factors including the forces acting between the components. In DPI formulations these forces are dominated by interparticulate interactions. Research has shown that adhesive and cohesive forces depend on a number of particulate properties such as size, surface roughness, crystallinity, surface energetics and combinations of these. With traditional methods the impact of particulate properties on interparticulate forces could be evaluated by examining the bulk properties. Atomic force microscopy (AFM), however, enables the determination of local surface characteristics and the direct measurement of interparticulate forces using the colloidal probe technique. AFM is considered extremely useful for evaluating the surface topography of a substrate (an API or carrier particle) and even allows the identification of crystal faces, defects and polymorphs from high-resolution images. Additionally, information is given about local mechanical properties of the particles and changes in surface composition and energetics. The assessment of attractive forces between two bodies is possible by using colloidal probe AFM.This review article summarises the application of AFM in DPI formulations while specifically focussing on the colloidal probe technique and the evaluation of interparticulate forces.2015 Elsevier B.V. All rights reserved.

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Section: Adhesion Measurementsmentioning

confidence: 99%

Characterisation of dry powder inhaler formulations using atomic force microscopy

Weiss

McLoughlin

Cathcart

2015

International Journal of Pharmaceutics

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“…In an effort to gain insight into this, Theophilus et al 147 investigated the deposition per actuation from the commercially available combination and single MDI products Seretide (50 μg fluticasone propionate and 25 μg salmeterol), Serevent (25 μg salmeterol), and Flixotide (50 μg fluticasone propionate). Being an in vitro size model of the central airways, Plate 4 of the ACI, having a size range of 2.1 to 3.3 μm, was analyzed by Raman spectroscopy following MDI actuation at a flow rate of 28.3 L/min.…”

Section: E10mentioning

confidence: 99%

“…The authors showed from their Raman chemical images that the combination inhalation product delivered from a single device had significantly greater codeposition of both drugs, which suggested that the particles in the combination MDI are associated until the particles are deposited. 147 It was acknowledged that while the ACI is an in vitro model of pulmonary deposition, the differences observed in vitro would be expected to be much greater in vivo. 147 Propellant evaporation is a rapid, dynamic, and complex interfacial process where the …”

Section: E10mentioning

confidence: 99%

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Raman characterization and chemical imaging of biocolloidal self-assemblies, drug delivery systems, and pulmonary inhalation aerosols: A review

Mansour

Hickey

2007

AAPS PharmSciTech

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This review presents an introduction to Raman scattering and describes the various Raman spectroscopy, Raman microscopy, and chemical imaging techniques that have demonstrated utility in biocolloidal self-assemblies, pharmaceutical drug delivery systems, and pulmonary research applications. Recent Raman applications to pharmaceutical aerosols in the context of pulmonary inhalation aerosol delivery are discussed. The "molecular fingerprint" insight that Raman applications provide includes molecular structure, drug-carrier/ excipient interactions, intramolecular and intermolecular bonding, surface structure, surface and interfacial interactions, and the functional groups involved therein. The molecular, surface, and interfacial properties that Raman characterization can provide are particularly important in respirable pharmaceutical powders, as these particles possess a higher surface-area-to-volume ratio; hence, understanding the nature of these solid surfaces can enable their manipulation and tailoring for functionality at the nanometer level for targeted pulmonary delivery and deposition. Moreover, Raman mapping of aerosols at the micro-and nanometer level of resolution is achievable with new, sophisticated, commercially available Raman microspectroscopy techniques. This noninvasive, highly versatile analytical and imaging technique exhibits vast potential for in vitro and in vivo molecular investigations of pulmonary aerosol delivery, lung deposition, and pulmonary cellular drug uptake and disposition in unfixed living pulmonary cells.

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“…More recently, Raman spectroscopy has emerged as a promising technique for studying particulate interactions especially in combination pressurised metered dose (pMDI) formulations (Rogueda et al, 2011;Steele et al, 2004;Theophilus et al, 2006). However, also studies where DPI products have been investigated using Raman spectroscopy have been published (Kinnunen et al 2009, Šašić andHarding, 2010).…”

Section: Introductionmentioning

confidence: 99%

Extrinsic lactose fines improve dry powder inhaler formulation performance of a cohesive batch of budesonide via agglomerate formation and consequential co-deposition

Kinnunen

Hebbink²,

Peters³

et al. 2015

International Journal of Pharmaceutics

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Price, R. (2015) 'Extrinsic lactose nes improve dry powder inhaler formulation performance of a cohesive batch of budesonide via agglomerate formation and consequential co-deposition.', International journal of pharmaceutics., 478 (1). pp. 53-59. Further information on publisher's website:http://dx.doi.org/10.1016/j.ijpharm.2014.11.019Publisher's copyright statement: NOTICE: this is the author's version of a work that was accepted for publication in International Journal of Pharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be re ected in this document. Changes may have been made to this work since it was submitted for publication. A de nitive version was subsequently published in International Journal of Pharmaceutics, 478, 1, 15 January 2015, 10.1016/j.ijpharm.2014 Additional information: Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-pro t purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. AbstractThe aim of the study was to investigate how the fine particle content of lactose carriers prepared with different types of lactose fines regulates dry powder inhaler (DPI) formulation performance of a cohesive batch of micronised budesonide.Budesonide formulations (0.8 wt-% ) were prepared with three different lactose carriers (Lactohale (LH) LH100, 20 wt-% LH210 in LH100 and 20 wt-% LH300 in LH100 indicated that the more fine lactose particles were available the more agglomerates of budesonide and lactose were delivered to the Stage 2. These results suggest drug-fines agglomerate formation is an important mechanism for how lactose fines improve and regulate DPI formulation performance.

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Co-deposition of salmeterol and fluticasone propionate by a combination inhaler☆

Cited by 47 publications

References 24 publications

Characterisation of dry powder inhaler formulations using atomic force microscopy

Characterisation of dry powder inhaler formulations using atomic force microscopy

Raman characterization and chemical imaging of biocolloidal self-assemblies, drug delivery systems, and pulmonary inhalation aerosols: A review

Extrinsic lactose fines improve dry powder inhaler formulation performance of a cohesive batch of budesonide via agglomerate formation and consequential co-deposition

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