Co-Delivery of Hispolon and Doxorubicin Liposomes Improves Efficacy Against Melanoma Cells

Saqr, Ahmed Al; Aldawsari, Mohammed F.; Alrbyawi, Hamad; Poudel, Ishwor; Annaji, Manjusha; Mulabagal, Vanisree; Ramani, Modukuri V.; Gottumukkala, Subbaraju; Tiwari, Amit K.; Dhanasekaran, Muralikrishnan; Panizzi, Peter; Arnold, Robert D.; Babu, R. Jayachandra

doi:10.1208/s12249-020-01846-2

Cited by 17 publications

(14 citation statements)

References 53 publications

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“…Overall, the antitumor function of hispolon involved STAT3 through the mitochondrial pathway. Alongside antioxidant property, hispolon exhibited anti-melanoma effect likewise curcumin through the inhibition of Bcl2 and overexpression of Bax further enhancement of caspase 1 and 3, downregulation of mitochondrial complex 1 and 4 activities 31 . Hispolons were also shown to be potent anticancer agents in the management of glioblastoma 32 , and prominently inhibited the proliferation of glioblastoma multiforme cells through activation of apoptic cascade such as caspase 3 and 9, and PARP cleavage.…”

Section: Phellinus Linteus -Black Hoof Mushroommentioning

confidence: 97%

Biological Activities of Hispolon

Kolla¹,

Bollikolla²

2022

CJST

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Natural products are a great source for the discovery of new chemotherapeutic agents. Phenolic compounds are significant natural products, mostly from the source of microorganisms and plants. Among fungi, mushrooms are not only the source of nutrients but also many bioactive components. In this paper, the authors made a comprehensive review of the biological activities of hispolon. The biological activities like anticancer, antioxidant, anti-inflammatory, and antimicrobial are possessed by hispolon. Along with anti-tuberculosis properties, hispolon exhibited effectiveness in the treatment of metabolic disorders and functional as immunomodulators.

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Section: Phellinus Linteus -Black Hoof Mushroommentioning

confidence: 97%

Biological Activities of Hispolon

Kolla¹,

Bollikolla²

2022

CJST

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“…Liposomes are widely used as drug carriers for small molecule, peptide, protein, gene and antibody delivery due to their high drug encapsulation, low drug toxicity, good targeting, good biocompatibility, biodegradability, and optimized biodegradability pharmacokinetic properties (77,(137)(138)(139). Liposomes are phagocytosed by macrophages after entering the body through intravenous injection, forming a natural aggregation effect and realizing macrophage targeting (140).…”

Section: Liposomes As Drug Carriers Target Macrophagesmentioning

confidence: 99%

Nanomaterials targeting macrophages in sepsis: A promising approach for sepsis management

Song

Gao

et al. 2022

Front. Immunol.

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Sepsis is a life-threatening organ dysfunction resulting from dysregulated host responses to infection. Macrophages play significant roles in host against pathogens and the immunopathogenesis of sepsis, such as phagocytosis of pathogens, secretion of cytokines, and phenotype reprogramming. However, the rapid progression of sepsis impairs macrophage function, and conventional antimicrobial and supportive treatment are not sufficient to restore dysregulated macrophages roles. Nanoparticles own unique physicochemical properties, surface functions, localized surface plasmon resonance phenomenon, passive targeting in vivo, good biocompatibility and biodegradability, are accessible for biomedical applications. Once into the body, NPs are recognized by host immune system. Macrophages are phagocytes in innate immunity dedicated to the recognition of foreign substances, including nanoparticles, with which an immune response subsequently occurs. Various design strategies, such as surface functionalization, have been implemented to manipulate the recognition of nanoparticles by monocytes/macrophages, and engulfed by them to regulate their function in sepsis, compensating for the shortcomings of sepsis traditional methods. The review summarizes the mechanism of nanomaterials targeting macrophages and recent advances in nanomedicine targeting macrophages in sepsis, which provides good insight for exploring macrophage-based nano-management in sepsis.

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“… 5 , 8 Literature search on nanostructured systems of HP shows only one report on codelivery with docetaxel in liposomes for improving the efficacy against melanoma cells. 10 …”

Section: Introductionmentioning

confidence: 99%

“…5,8 Literature search on nanostructured systems of HP shows only one report on codelivery with docetaxel in liposomes for improving the efficacy against melanoma cells. 10 In the recent decade, liquid crystalline nanoparticles (LCNPs) have been found as a promising tool for oral drug delivery applications. 11−13 LCNPs are self-assembled architectures formed when polar lipids are dispersed in an aqueous surfactant solution.…”

Section: Introductionmentioning

confidence: 99%

“…Anticancer agents are entrapped in the network, adsorbed on the surface, or both for drug targeting applications. ,, The potential of nanoparticle (NP) use for anticancer drug delivery is enormous, and they may be used for a wide range of therapeutic applications. Small particles having a larger surface area and a faster dissolution rate help in achieving better anticancer activity. , Literature search on nanostructured systems of HP shows only one report on codelivery with docetaxel in liposomes for improving the efficacy against melanoma cells …”

Section: Introductionmentioning

confidence: 99%

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Hispolon-Loaded Liquid Crystalline Nanoparticles: Development, Stability, In Vitro Delivery Profile, and Assessment of Hepatoprotective Activity in Hepatocellular Carcinoma

et al. 2022

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The present work describes the development and characterization of liquid crystalline nanoparticles of hispolon (HP-LCNPs) for treating hepatocellular carcinoma. HP-LCNPs were prepared by a top-down method utilizing GMO as the lipid and Pluronic F-127 as the polymeric stabilizer. The prepared formulations (HP1–HP8) were tested for long-term stability, where HP5 showed good stability with a particle size of 172.5 ± 0.3 nm, a polydispersity index (PDI) of 0.38 ± 0.31 nm, a zeta potential of −10.12 mV ± 0.05, an entrapment efficiency of 86.81 ± 2.5%, and a drug loading capacity of 12.51 ± 1.12%. Optical photomicrography and transmission electron microscopy images demonstrated a consistent, low degree of aggregation and a spherical shape of LCNPs. The effect of temperature and pH on the optimized formulation (HP5) indicated good stability at 45 °C and at pH between 2 and 5. In vitro gastrointestinal stability indicated no significant change in the particle size, PDI, and entrapment efficiency of the drug. The drug release study exhibited a biphasic pattern in simulated gastric fluid (pH 1.2) for 2 h and simulated intestinal fluid (pH 7.4) for up to 24 h, while the best fitting of the profile was observed with the Higuchi model, indicating the Fickian diffusion mechanism. The in vivo pharmacokinetic study demonstrated nearly 4.8-fold higher bioavailability from HP5 (AUC: 1774.3 ± 0.41 μg* h/mL) than from the HP suspension (AUC: 369.11 ± 0.11 μg* h/mL). The anticancer activity evaluation revealed a significant improvement in antioxidant parameters and serum hepatic biomarkers (SGOT, SGPT, ALP, total bilirubin, and GGT) in the diethyl nitrosamine-treated group of rats with the optimized LCNP formulation (HP5) vis-à-vis HP suspension.

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Co-Delivery of Hispolon and Doxorubicin Liposomes Improves Efficacy Against Melanoma Cells

Cited by 17 publications

References 53 publications

Biological Activities of Hispolon

Biological Activities of Hispolon

Nanomaterials targeting macrophages in sepsis: A promising approach for sepsis management

Hispolon-Loaded Liquid Crystalline Nanoparticles: Development, Stability, In Vitro Delivery Profile, and Assessment of Hepatoprotective Activity in Hepatocellular Carcinoma

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