Co-delivery of gemcitabine and salinomycin in PEGylated liposomes for enhanced anticancer efficacy against colorectal cancer

Tefas, Lucia Ruxandra; Toma, Ioana; Sesărman, Alina; Banciu, Manuela; Jurj, Ancuța; Berindan‐Neagoe, Ioana; Rus, Lucia; Știufiuc, Rareș; Tomuță, Ioan

doi:10.1080/08982104.2022.2153139

Cited by 8 publications

(4 citation statements)

References 67 publications

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“…Using human glioblastoma U-251 cells, this nanosystem improved cytotoxicity induction via apoptosis in comparison with free salinomycin by inducing intracellular ROS and upregulating the expression of RB Transcriptional Corepressor Like 1 and 2 tumor suppressor genes and of caspase 3 [60]. In vitro cytotoxicity studies on SW-620 human colorectal cancer cells showed that PEGylated liposomes co-encapsulating gemcitabine and salinomycin are more potent than the conventional drug alone (encapsulated or free), thus boding well for the use of this strategy also for the treatment of colorectal cancer [62].…”

Section: Passive Targetingmentioning

confidence: 99%

“…The poor aqueous solubility of salinomycin and its remarkable potency to kill cancer stem-like cells (CSCs) triggered the development of various nanosystems to encapsulate it and to improve salinomycin biodistribution and bioavailability, namely, polymeric micelles, nanofibers and nanoparticles, pegylated liposomes, and nanoemulsions [57][58][59][60][61][62]. Passivetargeting polymeric micelles made of PEG-b-poly(ε-caprolactone) (PEG-b-PCL) to load salinomycin were developed and combined with octreotide-modified paclitaxel-loaded PEG-b-PCL micelles as an alternative approach to improve the treatment of breast cancer.…”

Section: Passive Targetingmentioning

confidence: 99%

“…In vitro studies on the impact of nanoemulsions co-loading paclitaxel and salinomycin on stem cell-enriched mam-mospheres also revealed the potential of this synergistic approach to improve anticancer efficacy and eventually reduce systemic toxicity [57]. Nanosystems loading salinomycin were also designed to potentially treat glioblastoma and colorectal cancer [60,62]. Considering glioblastoma, salinomycin-loaded PLGA nanofibers were developed for local therapy and recurrence prevention upon implantation in the brain cavity after surgical removal of the tumor.…”

Section: Passive Targetingmentioning

confidence: 99%

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The Golgi Apparatus as an Anticancer Therapeutic Target

Martins,

Vieira,

Pereira-Leite

et al. 2023

Biology

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Although the discovery of the Golgi apparatus (GA) was made over 125 years ago, only a very limited number of therapeutic approaches have been developed to target this complex organelle. The GA serves as a modification and transport center for proteins and lipids and also has more recently emerged as an important store for some ions. The dysregulation of GA functions is implicated in many cellular processes associated with cancer and some GA proteins are indeed described as cancer biomarkers. This dysregulation can affect protein modification, localization, and secretion, but also cellular metabolism, redox status, extracellular pH, and the extracellular matrix structure. Consequently, it can directly or indirectly affect cancer progression. For these reasons, the GA is an appealing anticancer pharmacological target. Despite this, no anticancer drug specifically targeting the GA has reached the clinic and few have entered the clinical trial stage. Advances in nanodelivery approaches may help change this scenario by specifically targeting tumor cells and/or the GA through passive, active, or physical strategies. This article aims to examine the currently available anticancer GA-targeted drugs and the nanodelivery strategies explored for their administration. The potential benefits and challenges of modulating and specifically targeting the GA function in the context of cancer therapy are discussed.

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Section: Passive Targetingmentioning

confidence: 99%

Section: Passive Targetingmentioning

confidence: 99%

Section: Passive Targetingmentioning

confidence: 99%

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The Golgi Apparatus as an Anticancer Therapeutic Target

Martins,

Vieira,

Pereira-Leite

et al. 2023

Biology

View full text Add to dashboard Cite

show abstract

“…One of the important ways in improving blood circulation time of liposomes is to mediate their PEGylation that can increase their anti-cancer activity. Moreover, PEGylated liposomes can release drugs in a prolonged manner and they have no aggregation [53] . Therefore, liposomes are promising candidates in drug co-delivery and cancer suppression [54] .…”

Section: Liposomes In Cancer Therapy: a Summarymentioning

confidence: 99%