Co-delivery of dual chemo-drugs with precisely controlled, high drug loading polymeric micelles for synergistic anti-cancer therapy

Wu, Yuchen; Lv, Shixian; Li, Yongjuan; He, Hua; Ji, Yong; Zheng, Mingfeng; Liu, Yong; Yin, Lichen

doi:10.1039/c9bm01662g

Cited by 44 publications

(23 citation statements)

References 54 publications

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“…These nanomedicines are superior to conventional chemotherapeutic drugs, it can significantly reduce the systemic toxicity of chemotherapeutic drugs and improve the efficacy of chemotherapy 6 , 7 , 8 . However, due to the complex pathogenesis of tumors, the efficacy of mono-chemotherapy regimen is usually unsatisfactory, while multiple combination therapy holds promising prospects in cancer treatment 9 , 10 , 11 . Photothermal therapy (PTT) as a promising therapeutic model has emerged and attracted widespread interest owing to its minimal invasiveness and specific spatial and temporal selectivity 12 , 13 , 14 , 15 , 16 .…”

Section: Introductionmentioning

confidence: 99%

Tumor-targeted/reduction-triggered composite multifunctional nanoparticles for breast cancer chemo-photothermal combinational therapy

Yang

et al. 2022

Acta Pharmaceutica Sinica B

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Section: Introductionmentioning

confidence: 99%

Tumor-targeted/reduction-triggered composite multifunctional nanoparticles for breast cancer chemo-photothermal combinational therapy

Yang

et al. 2022

Acta Pharmaceutica Sinica B

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“…Expanding the circulation time allows sufficient accumulation of drug-loaded micelles at the targeted sites for slow-acting cancer therapy [39,41]. Wu et al [42] synthesized phenylboronic acid (PBA)-decorated methoxy polyethylene glycol-block-(poly-N-2-hydroxyethyl-aspartamide) (mPEG-b-PHEA/PBA (PPBA)) via self-assembly. The donor-acceptor coordination PBA moieties on the polymer backbones and two hydrophobic drugs (DOX and irinotecan (IR)) enhanced the concurrent loading of both DOX and IR.…”

Section: Polymeric Micellesmentioning

confidence: 99%

Development of Polymer-Assisted Nanoparticles and Nanogels for Cancer Therapy: An Update

Neerooa

Ooi

Shameli

et al. 2021

Gels

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With cancer remaining as one of the main causes of deaths worldwide, many studies are undergoing the effort to look for a novel and potent anticancer drug. Nanoparticles (NPs) are one of the rising fields in research for anticancer drug development. One of the key advantages of using NPs for cancer therapy is its high flexibility for modification, hence additional properties can be added to the NPs in order to improve its anticancer action. Polymer has attracted considerable attention to be used as a material to enhance the bioactivity of the NPs. Nanogels, which are NPs cross-linked with hydrophilic polymer network have also exhibited benefits in anticancer application. The characteristics of these nanomaterials include non-toxic, environment-friendly, and variable physiochemical properties. Some other unique properties of polymers are also attributed by diverse methods of polymer synthesis. This then contributes to the unique properties of the nanodrugs. This review article provides an in-depth update on the development of polymer-assisted NPs and nanogels for cancer therapy. Topics such as the synthesis, usage, and properties of the nanomaterials are discussed along with their mechanisms and functions in anticancer application. The advantages and limitations are also discussed in this article.

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“…As a result, these nanocarriers show greater blood circulation times and increased accumulation in the tumor [ 27 , 35 ]. Furthermore, nanocarriers allow the co-delivery of multiple therapeutics to the same site, limiting the variability in the biodistribution and dosage of each drug compared with the administration of two separate treatments [ 36 , 37 , 38 , 39 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

Combination Chemotherapy with Cisplatin and Chloroquine: Effect of Encapsulation in Micelles Formed by Self-Assembling Hybrid Dendritic–Linear–Dendritic Block Copolymers

González-Pastor

Lancelot

Morcuende-Ventura

et al. 2021

IJMS

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Clinical outcomes of conventional drug combinations are not ideal due to high toxicity to healthy tissues. Cisplatin (CDDP) is the standard component for many cancer treatments, yet its principal dose-limiting side effect is nephrotoxicity. Thus, CDDP is commonly used in combination with other drugs, such as the autophagy inhibitor chloroquine (CQ), to enhance tumor cell killing efficacy and prevent the development of chemoresistance. In addition, nanocarrier-based drug delivery systems can overcome chemotherapy limitations, decreasing side effects and increasing tumor accumulation. The aim of this study was to evaluate the toxicity of CQ and CDDP against tumor and non-tumor cells when used in a combined treatment. For this purpose, two types of micelles based on Pluronic® F127 hybrid dendritic–linear–dendritic block copolymers (HDLDBCs) modified with polyester or poly(esteramide) dendrons derived from 2,2′-bis(hydroxymethyl)propionic acid (HDLDBC-bMPA) or 2,2′-bis(glycyloxymethyl)propionic acid (HDLDBC-bGMPA) were explored as delivery nanocarriers. Our results indicated that the combined treatment with HDLDBC-bMPA(CQ) or HDLDBC-bGMPA(CQ) and CDDP increased cytotoxicity in tumor cells compared to the single treatment with CDDP. Encapsulations demonstrated less short-term cytotoxicity individually or when used in combination compared to the free drugs. However, and more importantly, a low degree of cytotoxicity against non-tumor cells was maintained, even when drugs were given simultaneously.

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Co-delivery of dual chemo-drugs with precisely controlled, high drug loading polymeric micelles for synergistic anti-cancer therapy

Abstract: The introduction of donor-receptor coordination between micelles and drug payloads provides a precise co-delivery strategy for two different chemo-drugs with high drug loading and ROS responsiveness.

Cited by 44 publications

References 54 publications

Tumor-targeted/reduction-triggered composite multifunctional nanoparticles for breast cancer chemo-photothermal combinational therapy

Tumor-targeted/reduction-triggered composite multifunctional nanoparticles for breast cancer chemo-photothermal combinational therapy

Development of Polymer-Assisted Nanoparticles and Nanogels for Cancer Therapy: An Update

Combination Chemotherapy with Cisplatin and Chloroquine: Effect of Encapsulation in Micelles Formed by Self-Assembling Hybrid Dendritic–Linear–Dendritic Block Copolymers

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