Co-delivery of doxorubicin and tumor-suppressing p53 gene using a POSS-based star-shaped polymer for cancer therapy

Li, Yongmao; Xu, Bing; Bai, Tao; Liu, Wenguang

doi:10.1016/j.biomaterials.2015.03.034

Cited by 82 publications

(51 citation statements)

References 37 publications

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“…The most desirable factor for using ATRP is its ability to prepare well‐defined polymers to produce definite polymerization products. Li et al, for example, used ATRP to graft a polyhedral oligomeric silsesquioxane (POSS)‐based initiator with block polymers from cationic poly[2‐(dimethylamino) ethyl methacrylate] (PDMAEMA) and zwitterionic poly[ N ‐(3‐methacryloylamino) propyl)‐ N , N ‐dimethyl‐ N ‐(3‐sulfopropyl) ammonium hydroxide] (PMPDSAH) . In this study, the POSS‐based octafunctional ATRP initiator was prepared by one step reaction consisting of complex processes of hydrolysis, dehydration, condensation, and structure reforming, which is different from the transesterification reaction reported in previously reported POSS–PDMAEMA star polymers .…”

Section: Polymerization Techniquesmentioning

confidence: 99%

Nano‐Star‐Shaped Polymers for Drug Delivery Applications

Yang

Deen

et al. 2017

Macromol. Rapid Commun.

121

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With the advancement of polymer engineering, complex star-shaped polymer architectures can be synthesized with ease, bringing about a host of unique properties and applications. The polymer arms can be functionalized with different chemical groups to fine-tune the response behavior or be endowed with targeting ligands or stimuli responsive moieties to control its physicochemical behavior and self-organization in solution. Rheological properties of these solutions can be modulated, which also facilitates the control of the diffusion of the drug from these star-based nanocarriers. However, these star-shaped polymers designed for drug delivery are still in a very early stage of development. Due to the sheer diversity of macromolecules that can take on the star architectures and the various combinations of functional groups that can be cross-linked together, there remain many structure-property relationships which have yet to be fully established. This review aims to provide an introductory perspective on the basic synthetic methods of star-shaped polymers, the properties which can be controlled by the unique architecture, and also recent advances in drug delivery applications related to these star candidates.

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Section: Polymerization Techniquesmentioning

confidence: 99%

Nano‐Star‐Shaped Polymers for Drug Delivery Applications

Yang

Deen

et al. 2017

Macromol. Rapid Commun.

121

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“…Therefore, co-delivery of pDNA encoding p53 can synergize the anticancer effect of Dox [104]. Li et al reported NP based on a star-shaped block co-polymer for the co-delivery of p53-pDNA and Dox [105]. The polymer was built upon hydrophobic polyhedral oligomeric silsesquioxane (POSS), which formed a core to entrap Dox, with branches of cationic poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA) and zwitterionic poly[N-(3-(methacryloylamino) propyl)-N,N-dimethyl-N-(3-sulfopropyl)ammonium hydroxide] (PMPDSAH), which formed a cationic shell for pDNA complexation and non-fouling corona for systemic application, respectively.…”

Section: Simultaneous Deliverymentioning

confidence: 99%

“…The polymer was built upon hydrophobic polyhedral oligomeric silsesquioxane (POSS), which formed a core to entrap Dox, with branches of cationic poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA) and zwitterionic poly[N-(3-(methacryloylamino) propyl)-N,N-dimethyl-N-(3-sulfopropyl)ammonium hydroxide] (PMPDSAH), which formed a cationic shell for pDNA complexation and non-fouling corona for systemic application, respectively. The dual-loaded NP showed a greater p53 protein expression level in cancer cells and a greater anti-tumor effect in a MCF-7 xenograft model than single component NP due to the synergistic effect of p53-pDNA and Dox [105]. …”

Section: Simultaneous Deliverymentioning

confidence: 99%

Organic nanoparticle systems for spatiotemporal control of multimodal chemotherapy

Meng¹,

Han²,

Yeo³

2016

Expert Opinion on Drug Delivery

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Introduction Chemotherapeutic drugs are used in combination to target multiple mechanisms involved in cancer cell survival and proliferation. Carriers are developed to deliver drug combinations to common target tissues in optimal ratios and desirable sequences. Nanoparticles (NP) have been a popular choice for this purpose due to their ability to increase the circulation half-life and tumor accumulation of a drug. Areas covered We review organic NP carriers based on polymers, proteins, peptides, and lipids for simultaneous delivery of multiple anticancer drugs, drug/sensitizer combinations, drug/photodynamic- or photothermal therapy combinations, and drug/gene therapeutics with examples in the past three years. Sequential delivery of drug combinations, based on either sequential administration or built-in release control, is introduced with an emphasis on the mechanistic understanding of such control. Expert opinion Recent studies demonstrate how a drug carrier can contribute to co-localizing drug combinations in optimal ratios and dosing sequences to maximize the synergistic effects. We identify several areas for improvement in future research, including the choice of drug combinations, circulation stability of carriers, spatiotemporal control of drug release, and the evaluation and clinical translation of combination delivery.

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“…Poly(sulfobetaine methacrylate) (PSBMA) has proven promising in the hydrophilic modification of polycation gene vectors because of the biocompatibility, which provides a fouling resistance to plasma proteins due to the surface hydrophilicity resulting from the charge bias . PDMAEMA‐b‐PSBMA has been observed to exhibit lower cytotoxicity than homo‐PDMAEMA, while retaining a good DNA condensation capability and achieving much superior gene transfection efficiency . Furthermore, PDMAEMA‐b‐PSBMA could be grafted onto luminescent carbon dots for facile gene transfection detection and imaging .…”

Section: Introductionmentioning

confidence: 99%

Microscopic insight into the DNA condensation process of a zwitterion‐functionalized polycation

et al. 2016

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Zwitterion-functionalized polycations are ideal gene carriers with long circulation, high cellular uptaking and low cell viability. However, the trade-off between the DNA condensation efficiency and the cell viability must be addressed. The purpose of this study is to provide a microscopic insight into the DNA condensation process and to explore the effect of a zwitterionic block of zwitterion-functionalized polycation, which is of great significance in designing novel gene delivery systems. Poly[2-(dimethylamino)ethyl methacrylate-b-(sulfobetaine methacrylate)] (PDMAEMA-b-PSBMA) copolymers were synthesized and used as the model systems. Different from the conventional concept that the PSBMA zwitterionic block act only as the "stealthy" groups, the subtle differences in physical and colloidal characteristics between the polycation/DNA polyplexes show that the PSBMA segment is capable of wrapping DNA attributed to the quaternary ammonium cations, without compromising the DNA condensation capability. On the other hand, the incorporation of PSBMA block reduces the surface charge of the polyplexes, which substantially result in the inefficient transfection and the reduced cytotoxicity.

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Co-delivery of doxorubicin and tumor-suppressing p53 gene using a POSS-based star-shaped polymer for cancer therapy

Cited by 82 publications

References 37 publications

Nano‐Star‐Shaped Polymers for Drug Delivery Applications

Nano‐Star‐Shaped Polymers for Drug Delivery Applications

Organic nanoparticle systems for spatiotemporal control of multimodal chemotherapy

Microscopic insight into the DNA condensation process of a zwitterion‐functionalized polycation

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