Co-delivery of doxorubicin and curcumin by a pH-sensitive, injectable, and in situ hydrogel composed of chitosan, graphene, and cellulose nanowhisker

Omidi, Sakineh; Pirhayati, Mozhgan; Kakanejadifard, Ali

doi:10.1016/j.carbpol.2019.115745

Cited by 87 publications

(45 citation statements)

References 22 publications

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“…Omidi et al developed pH-responsive DOX-loaded hydrogel composed of CS, aminated-graphene, and amino-functionalized cellulose nanowhisker cross-linked by dialdehyde (DOX-CGW) [92]. Field Emission Scanning Electron Microscopes images showed a randomly porous structure with DOX accumulated on the surface of CGW, which remained stable at PBS buffer (pH 7.4) after 6 h, contrarily to distilled water.…”

Section: Drug Delivery Systems Responsive To Physical and Chemical Stmentioning

confidence: 99%

Polymeric Nanocarriers: A Transformation in Doxorubicin Therapies

Butowska

Woziwodzka

Borowik

et al. 2021

Preprint

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Doxorubicin, a member of the anthracycline family, is a common anticancer agent often used as a first line treatment for the wide spectrum of cancers. Doxorubicin-based chemotherapy, although effective, is associated with serious side effects, such as irreversible cardiotoxicity or nephrotoxicity. Those often life-threatening adverse risks, responsible for the elongation of the patients' recuperation period and increasing medical expenses, have prompted the need for creating novel and safer drug delivery systems. Among many proposed concepts, polymeric nanocarriers are shown to be a promising approach, allowing for controlled and selective drug delivery simultaneously enhancing its activity towards cancerous cells and reducing toxic effects on healthy tissues. This article is a chronological examination of the history of the work progress on polymeric nanostructures, designed as efficient doxorubicin nanocarriers, with the emphasis on the main achievements of 2010-2020. Numerous publications have been reviewed to provide an essential summation of the nanopolymer types and their essential properties, mechanisms towards efficient drug delivery, as well as active targeting stimuli-responsive strategies that are currently utilized in the doxorubicin transportation field.

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Section: Drug Delivery Systems Responsive To Physical and Chemical Stmentioning

confidence: 99%

Polymeric Nanocarriers: A Transformation in Doxorubicin Therapies

Butowska

Woziwodzka

Borowik

et al. 2021

Preprint

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“…The emerging of CNC/GN hybrids has pushed the scientific community to develop a new generation of efficient hydrogels. Omidi et al have successfully developed a pH-responsive hydrogel containing aminated CNC (WN), aminated graphene (GN) and chitosan via Schiff base reaction by a synthetic dialdehyde in a few minutes [ 142 ]. The preparation procedure is schematized in Figure 5 E. The prepared hydrogel exhibited better sensitivity to different external stimuli encompassing pH and amino acids.…”

Section: Preparation Properties and Application Of Cnc/gnm Hybridmentioning

confidence: 99%

“…Copyright ©2018, The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC; ( E ) Preparation procedure of chitosan/WN/GN hydrogel. Reproduced with permission from Reference [ 142 ]. Copyright ©2020, Elsevier; ( F ) TEM images of GN and CNC/GN sol mixtures containing 2 wt.% of GN.…”

Section: Figurementioning

confidence: 99%

Cellulose Nanocrystals/Graphene Hybrids—A Promising New Class of Materials for Advanced Applications

2020

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With the growth of global fossil-based resource consumption and the environmental concern, there is an urgent need to develop sustainable and environmentally friendly materials, which exhibit promising properties and could maintain an acceptable level of performance to substitute the petroleum-based ones. As elite nanomaterials, cellulose nanocrystals (CNC) derived from natural renewable resources, exhibit excellent physicochemical properties, biodegradability and biocompatibility and have attracted tremendous interest nowadays. Their combination with other nanomaterials such as graphene-based materials (GNM) has been revealed to be useful and generated new hybrid materials with fascinating physicochemical characteristics and performances. In this context, the review presented herein describes the quickly growing field of a new emerging generation of CNC/GNM hybrids, with a focus on strategies for their preparation and most relevant achievements. These hybrids showed great promise in a wide range of applications such as separation, energy storage, electronic, optic, biomedical, catalysis and food packaging. Some basic concepts and general background on the preparation of CNC and GNM as well as their key features are provided ahead.

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“…The researchers in the related fields have tried to develop in situ hydrogel system achieving two main goals of drug administration: the first one is to specifically and safely deliver and target the drug to its site of action through local drug delivery (intratumor/paratumor) to maximize its therapeutic efficacy while minimizing its toxicity, based on enhanced antitumor activity with increasing concentration of anti-tumor drugs at the target site (tumor); the second one is to extend the duration of the tumor's exposure to the drug and maintain its release from the formulated drug carrier to help maintain its therapeutic effect after administration. The in situ hydrogel forms a drug depot at the injection site, which may reduce the total number of injections throughout the drug treatment process (Bendas et al, 2013;Moghassemi & Hadjizadeh, 2014;Shaker et al, 2015;Xing et al, 2015Xing et al, , 2019Omidi et al, 2020). In order to summarize and improve study the application of in situ hydrogel system in tumor treatment, this paper focuses on the recent research progress in related areas.…”

Section: Introductionmentioning

confidence: 99%

Research progress in the application of in situ hydrogel system in tumor treatment

Wei

Yin

et al. 2020

Drug Delivery

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The in situ hydrogel drug delivery system is a hot research topic in recent years. Combining both properties of hydrogel and solution, in situ hydrogels can provide many advantages for drug delivery application, including easy application, high local drug concentration, prolonged drug retention time, reduced drug dose in vivo, good biocompatibility and improved patient compliance, thus has potential in tumor treatment. In this paper, the related literature reports in recent years were reviewed to summarize and discuss the research progress and development prospects in the application of in situ hydrogels in tumor treatment. ARTICLE HISTORY

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Co-delivery of doxorubicin and curcumin by a pH-sensitive, injectable, and in situ hydrogel composed of chitosan, graphene, and cellulose nanowhisker

Cited by 87 publications

References 22 publications

Polymeric Nanocarriers: A Transformation in Doxorubicin Therapies

Polymeric Nanocarriers: A Transformation in Doxorubicin Therapies

Cellulose Nanocrystals/Graphene Hybrids—A Promising New Class of Materials for Advanced Applications

Research progress in the application of in situ hydrogel system in tumor treatment

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