Co-delivery of doxorubicin and curcumin via cRGD-peptide modified PEG-PLA self-assembly nanomicelles for lung cancer therapy

Zhang, Yunchu; Li, Tingting; Hu, Yuzhu; Chen, Jing; He, Yihong; Gao, Xiang; Zhang, Yan

doi:10.1016/j.cclet.2021.11.076

Cited by 30 publications

(15 citation statements)

References 36 publications

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“…[11][12][13][14] The fiveyear survival rate of lung cancer patients is less than 20 % due to early metastasis and ineffective early therapies. [15][16][17] Hence, the inhibition of lung cancer cell metastasis plays an important role in lung cancer treatment. However, only a few inhibitors have been reported in recent years.…”

Section: Introductionmentioning

confidence: 99%

“…Malignant tumors are characterized by abnormal proliferation, invasion, and metastasis, which cause great difficulties in cancer treatment [11–14] . The five‐year survival rate of lung cancer patients is less than 20 % due to early metastasis and ineffective early therapies [15–17] . Hence, the inhibition of lung cancer cell metastasis plays an important role in lung cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

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Rational Optimizations of the Marine‐Derived Peptide Sungsanpin as Novel Inhibitors of Cell Invasion

Zhang¹,

Zou³

et al. 2023

Chemistry & Biodiversity

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Cancer metastasis, including cell invasion, is a major cause of poor clinical outcomes and death in numerous cancer patients. In recent years, many efforts have been made to develop potent therapeutic molecules from naturally derived peptides. Sungsanpin is a naturally derived lasso peptide that inhibits A549 cell invasion. We aimed to evaluate the potential of sungsanpin derivatives as candidates for anti-invasion drugs. We synthesized an analog of sungsanpin (Sun A) using a solid-phase peptide synthesis strategy (SPPS) and further modified its structure to improve its anti-invasion activity. All peptides were tested for their proliferative inhibition and antiinvasion activities in the A549 cell lines. Octapeptide S3 and cyclooctapeptide S4 upregulated the expression of TIMP-1 and TIMP-2 mRNA effectively and thus improved the inhibitory effect on the invasion of A549 cells. The two peptides can inhibit the invasion of A549 cells by up to 60 %, suggesting that they have potential as lead molecules for the development of peptide inhibitors.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rational Optimizations of the Marine‐Derived Peptide Sungsanpin as Novel Inhibitors of Cell Invasion

Zhang¹,

Zou³

et al. 2023

Chemistry & Biodiversity

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“…On the 20th day, d -luciferin (150 mg/kg) was given to the mice by intraperitoneal injection and in vivo and ex vivo bioluminescence signals of the lungs representing the tumor burden of animals were captured using an IVIS imaging system . The lung tissues were also visualized under a microscope after H&E 4 and Ki-67 staining …”

Section: Methodsmentioning

confidence: 99%

“…33 The lung tissues were also visualized under a microscope after H&E 4 and Ki-67 staining. 34 2.11. Toxicity Studies.…”

Section: Surface Functionalization Of Pull−ss−ptx Nps With Tf and Cha...mentioning

confidence: 99%

Engineering Transferrin-Decorated Pullulan-Based Prodrug Nanoparticles for Redox Responsive Paclitaxel Delivery to Metastatic Lung Cancer Cells

Zhao

Guo

Bera

et al. 2023

ACS Appl. Mater. Interfaces

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Paclitaxel (PTX) remains a cornerstone in the treatment of locally advanced and metastatic lung cancer. To improve its therapeutic indices against lung cancer, novel redox-sensitive pullulan/PTX-based prodrug NPs (PULL–SS–PTX NPs) were accomplished, which were further surface-decorated with transferrin (TF), a cancer cell-targeting ligand, to afford TF–PULL–SS–PTX NPs. These prodrug NPs (drug content, >37% and average size, 134–163 nm) rapidly dismantled their self-assembled architecture upon exposure to simulated reducing conditions, causing a triggered drug release as compared to the control scaffold (PULL–CC–PTX NPs). These scaffolds also evidenced outstanding colloidal stability, cellular uptake efficiency, and discriminating cytotoxicity between the cancer and healthy cells. Intravenously delivered redox-sensitive NPs exhibited improved tumor-suppressing properties as compared to the control nanovesicles (PULL–CC–PTX NPs) in a B16–F10 melanoma lung metastasis mice model. The targeting efficiency and associated augmented anticancer potentials of TF–PULL–SS–PTX NPs relative to TF-free redox-responsive NPs and Taxol intravenous injection were also established on the transferrin receptor (TFR) overexpressed Lewis lung carcinoma (LLC–luc) cell-bearing mice model. Moreover, the TF-functionalized scaffold displayed a reduced systemic toxicity compared to that of Taxol intravenous injection. Overall, the proposed TF-decorated prodrug NPs could be a promising nanomedicine for intracellular PTX delivery against metastatic lung cancer.

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“…Photothermal treatment (PTT) is another most common noninvasive phototherapy for tumor ablations, which is not affected by the O 2 concentration and is a good candidate to treat hypoxic tumors. 25–28 Thus, PTT and PDT combinations have been proved to be an effective strategy to achieve synergistic antitumor effects. 29,30 However, PTT also has the problem of inefficient photothermal conversion efficiency, inadequate conversion stability, 31 painful therapeutic procedures and serious healthy tissue damage.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional and multimodality theranostic nanomedicine for enhanced phototherapy

et al. 2023

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Co-delivery of doxorubicin and curcumin via cRGD-peptide modified PEG-PLA self-assembly nanomicelles for lung cancer therapy

Cited by 30 publications

References 36 publications

Rational Optimizations of the Marine‐Derived Peptide Sungsanpin as Novel Inhibitors of Cell Invasion

Rational Optimizations of the Marine‐Derived Peptide Sungsanpin as Novel Inhibitors of Cell Invasion

Engineering Transferrin-Decorated Pullulan-Based Prodrug Nanoparticles for Redox Responsive Paclitaxel Delivery to Metastatic Lung Cancer Cells

Multifunctional and multimodality theranostic nanomedicine for enhanced phototherapy

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