Co-delivery of Doxorubicin and Ceramide in a Liposomal Formulation Enhances Cytotoxicity in Murine B16BL6 Melanoma Cell Lines

Chen, Li; Alrbyawi, Hamad; Poudel, Ishwor; Arnold, Robert D.; Babu, R. Jayachandra

doi:10.1208/s12249-019-1316-0

Cited by 29 publications

(9 citation statements)

References 59 publications

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“…Coencapsulation of PTX and ceramide decreased the concentration necessary to reduce cell viability by 2.5-4.5-fold to 50% (EC 50 ), indicating a synergistic effect [332]. In other studies, codelivery of ceramide and DOX through lipid nanocarriers was effective in enhancing the antitumor efficacy of DOX in vitro and in murine melanoma models [333,334]. reported an antitumor efficacy of 93.94 ± 2.77% for a multifunctional nanocarrier, a finding that was significantly higher than that of a single drug-loaded nanocarrier and the Duopafei® control [334].…”

Section: Multifunctional Delivery Systemsmentioning

confidence: 87%

Nanotechnology approaches in the current therapy of skin cancer

Borgheti-Cardoso

Viegas

Silvestrini

et al. 2020

Advanced Drug Delivery Reviews

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Skin cancer is a high burden disease with a high impact on global health. Conventional therapies have several drawbacks; thus, the development of effective therapies is required. In this context, nanotechnology approaches are an attractive strategy for cancer therapy because they enable the efficient delivery of drugs and other bioactive molecules to target tissues with low toxic effects. In this review, nanotechnological tools for skin cancer will be summarized and discussed. First, pathology and conventional therapies will be presented, followed by the challenges of skin cancer therapy. Then, the main features of developing efficient nanosystems will be discussed, and next, the most commonly used nanoparticles (NPs) described in the literature for skin cancer therapy will be presented. Subsequently, the use of NPs to deliver chemotherapeutics, immune and vaccine molecules and nucleic acids will be reviewed and discussed as will the combination of physical methods and NPs. Finally, multifunctional delivery systems to codeliver anticancer therapeutic agents containing or not surface functionalization will be summarized.

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Section: Multifunctional Delivery Systemsmentioning

confidence: 87%

Nanotechnology approaches in the current therapy of skin cancer

Borgheti-Cardoso

Viegas

Silvestrini

et al. 2020

Advanced Drug Delivery Reviews

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“…Due to the high toxicity of conventional chemotherapeutic agents and poor drug delivery, nanomedicines have emerged as a novel tool to improve cancer treatment. Based on the drug's physicochemical properties, nano‐formulations with improved stability, greater circulation half‐lives, enhanced intratumor deposition, and controlled release can be achieved 31‐33 . These properties can be optimized to improve antitumor activity and reduce toxicity to nontarget, healthy tissues 34,35 .…”

Section: Nanotechnology For Delivery Of Resveratrolmentioning

confidence: 99%

Resveratrol‐loaded nanomedicines for cancer applications

et al. 2021

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Background Resveratrol (3, 5, 4′‐trihydroxystilbene), a natural polyphenol and phytoalexin, has drawn considerable attention in the past decade due to its wide variety of therapeutic activities such as anticancer, anti‐inflammatory, and antioxidant properties. However, its poor water solubility, low chemical stability, and short biological half‐life limit its clinical utility. Recent findings Nanoparticles overcome the limitations associated with conventional chemotherapeutic drugs, such as limited availability of drugs to the tumor tissues, high systemic exposures, and consequent toxicity to healthy tissues. This review focuses on the physicochemical properties of resveratrol, the therapeutic potential of resveratrol nano‐formulations, and the anticancer activity of resveratrol encapsulated nanoparticles on various malignancies such as skin, breast, prostate, colon, liver, ovarian, and lung cancers (focusing on both in vitro and in vivo studies). Conclusions Nanotechnology approaches have been extensively utilized to achieve higher solubility, improved oral bioavailability, enhanced stability, and controlled release of resveratrol. The resveratrol nanoparticles have markedly enhanced its anticancer activity both in vitro and in vivo, thus considering it as a potential strategy to fight various cancers.

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“…The size-dependent coupling of graphene nanosheets with DNA molecules was reported that GQDs have a limited lateral dimension and the capacity of DNA molecules to intercalate is most apparent. Moreover, Doxorubicin (DOX) is a frequently used therapeutic agent for human cancers such as sarcoma of the soft tissue, aggressive non-Hodgkin's lymphoma, and breast cancer [170]. The targeted drug binds to the GQDs functional groups and the drug is loaded onto the surface through the π-π interaction for precise DOX delivery into tumor cells.…”

Section: Drug Delivery Formulating Systemsmentioning

confidence: 99%

Outstanding Graphene Quantum Dots from Carbon Source for Biomedical and Corrosion Inhibition Applications: A Review

et al. 2021

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Graphene quantum dots (GQD) is an efficient nanomaterial composed of one or more layers of graphene with unique properties that combine both graphene and carbon dots (CDs). It can be synthesized using carbon-rich materials as precursors, such as graphite, macromolecules polysaccharides, and fullerene. This contribution emphasizes the utilization of GQD-based materials in the fields of sensing, bioimaging, energy storage, and corrosion inhibitors. Inspired by these numerous applications, various synthetic approaches have been developed to design and fabricate GQD, particularly bottom-up and top-down processes. In this context, the prime goal of this review is to emphasize possible eco-friendly and sustainable methodologies that have been successfully employed in the fabrication of GQDs. Furthermore, the fundamental and experimental aspects associated with GQDs such as possible mechanisms, the impact of size, surface alteration, and doping with other elements, together with their technological and industrial applications have been envisaged. Till now, understanding simple photo luminance (PL) operations in GQDs is very critical as well as there are various methods derived from the optical properties of manufactured GQDs can differ. Lack of determining exact size and morphology is highly required without loss of their optical features. Finally, GQDs are promising candidates in the after-mentioned application fields.

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Co-delivery of Doxorubicin and Ceramide in a Liposomal Formulation Enhances Cytotoxicity in Murine B16BL6 Melanoma Cell Lines

Cited by 29 publications

References 59 publications

Nanotechnology approaches in the current therapy of skin cancer

Nanotechnology approaches in the current therapy of skin cancer

Resveratrol‐loaded nanomedicines for cancer applications

Outstanding Graphene Quantum Dots from Carbon Source for Biomedical and Corrosion Inhibition Applications: A Review

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