Co-delivery of curcumin and quercetin in shellac nanocapsules for the synergistic antioxidant properties and cytotoxicity against colon cancer cells

Jain, Surangna; Lenaghan, Scott C.; Dia, Vermont P.; Zhong, Qixin

doi:10.1016/j.foodchem.2023.136744

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Spms For Delivery Of Bcs In Food Products and Targeted Deliv...1

Nanoparticle-based Delivery Systems For Chalcones1

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2025

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Cited by 10 publications

(2 citation statements)

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“…105 Co-encapsulation of curcumin and quercetin in shellac micelles enabled the synergistic antioxidant and cytotoxic properties of the polyphenols, while maintaining the characteristics feasible for colon delivery. 106…”

Section: Spms For Delivery Of Bcs In Food Products and Targeted Deliv...mentioning

confidence: 99%

Structured soft particulate matters for delivery of bioactive compounds in foods and functioning in the colon

Zhong,

Reyes-Jurado,

Calumba

2024

Soft Matter

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Section: Spms For Delivery Of Bcs In Food Products and Targeted Deliv...mentioning

confidence: 99%

Structured soft particulate matters for delivery of bioactive compounds in foods and functioning in the colon

Zhong,

Reyes-Jurado,

Calumba

2024

Soft Matter

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“…One of the primary derivatives of chalcones explored in the context of colon cancer treatment is CUR. Notably, several NP-based formulations, including liposomes, micelles, nanogels, chitosan, and polymeric NPs, have been developed, demonstrating their effectiveness in combatting colon cancer in both in vitro and in vivo studies ( Table 2 ) [ 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 ]. Additionally, innovative delivery systems have emerged.…”

Section: Nanoparticle-based Delivery Systems For Chalconesmentioning

confidence: 99%

Natural Chalcones and Derivatives in Colon Cancer: Pre-Clinical Challenges and the Promise of Chalcone-Based Nanoparticles

Hba,

Ghaddar,

Wahnou

et al. 2023

Pharmaceutics

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Colon cancer poses a complex and substantial global health challenge, necessitating innovative therapeutic approaches. Chalcones, a versatile class of compounds with diverse pharmacological properties, have emerged as promising candidates for addressing colon cancer. Their ability to modulate pivotal signaling pathways in the development and progression of colon cancer makes them invaluable as targeted therapeutics. Nevertheless, it is crucial to recognize that although chalcones exhibit promise, further pre-clinical studies are required to validate their efficacy and safety. The journey toward effective colon cancer treatment is multifaceted, involving considerations such as optimizing the sequencing of therapeutic agents, comprehending the resistance mechanisms, and exploring combination therapies incorporating chalcones. Furthermore, the integration of nanoparticle-based drug delivery systems presents a novel avenue for enhancing the effectiveness of chalcones in colon cancer treatment. This review delves into the mechanisms of action of natural chalcones and some derivatives. It highlights the challenges associated with their use in pre-clinical studies, while also underscoring the advantages of employing chalcone-based nanoparticles for the treatment of colon cancer.

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Improvement of quercetin bioaccessibility by whey protein isolate/D-tagatose conjugates: Effect on the structural characterization through simultaneous rheological and FTIR techniques

Chen,

Meng,

Lin

et al. 2025

Food Hydrocolloids

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Co-delivery of curcumin and quercetin in shellac nanocapsules for the synergistic antioxidant properties and cytotoxicity against colon cancer cells

Cited by 10 publications

References 38 publications

Structured soft particulate matters for delivery of bioactive compounds in foods and functioning in the colon

Structured soft particulate matters for delivery of bioactive compounds in foods and functioning in the colon

Natural Chalcones and Derivatives in Colon Cancer: Pre-Clinical Challenges and the Promise of Chalcone-Based Nanoparticles

Improvement of quercetin bioaccessibility by whey protein isolate/D-tagatose conjugates: Effect on the structural characterization through simultaneous rheological and FTIR techniques

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