Co-delivery of celastrol and lutein with pH sensitive nano micelles for treating acute kidney injury

Pang, Mingquan; Duan, Songchao; Zhao, Mengmeng; Jiao, Qingqing; Bai, Yimeng; Yu, Lili; Du, Bin; Cheng, Genyang

doi:10.1016/j.taap.2022.116155

Cited by 6 publications

(7 citation statements)

References 53 publications

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“…The critical micelle concentration (CMC) of CS-DA was measured by pyrene fluorescence assay. 48 In brief, pyrene was added into CS-DA solutions of different concentrations and sonicated in a water bath for 4 h. The fluorescence intensities (I) of CS-DA solutions at 373 and 384 nm were measured with 333 nm as the excitation wavelength. From the pyrene emission spectra, the ratio of I 373 /I 384 was analyzed for the calculation of CMC.…”

Section: Methodsmentioning

confidence: 99%

Intestinal Absorption of Nanoparticles to Reduce Oxidative Stress and Vasoconstriction for Treating Diabetic Nephropathy

Liu,

Pang,

Wang

et al. 2024

ACS Biomater. Sci. Eng.

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The etiology of diabetic nephropathy (DN) is complex, and the incidence is increasing year by year. The patient's kidney showed oxidative stress damage, increasing active oxygen species (ROS) content, and vasoconstriction. Due to poor drug solubility and low renal accumulation, the current treatment regimens have not effectively alleviated glomerulopathy and other kidney damage caused by DN. Therefore, it is of great significance to explore new treatment strategies and drug delivery systems. Here, we constructed an oral nanodelivery system (Tel/CAN@CS-DA) that reduced oxidative stress and vasoconstriction. Deoxycholic acid (DA)-modified nanoparticles entered into intestinal epithelial cells (Caco2 cells) via the bile acid biomimetic pathway, then escaped from the lysosomes and eventually spat out the cells, increasing the oral absorption of nanoparticles. Chitosan (CS) nanoparticles could achieve renal targeting through specific binding with a renal giant protein receptor and deliver drugs to renal tubule epithelial cells (HK-2 cells). In vitro studies also proved that telmisartan (Tel) and canagliflozin (CAN) effectively removed cellular reactive oxygen species (ROS) and reduced HK-2 cell apoptosis caused by high glucose. In the in vivo model induced by streptozotocin (STZ), the results showed that the nanosystem not only elevated AMPK protein expression, inhibited angiotensin II (Ang II) protein expression to effectively reduce oxidative stress level, dilated renal blood vessels but also reduced the degree of inflammation and fibrosis. Overall, Tel/CAN@CS-DA multifunctional oral nanosystem can effectively treat DN with low toxicity, which provides a new idea for the treatment of DN.

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Section: Methodsmentioning

confidence: 99%

Intestinal Absorption of Nanoparticles to Reduce Oxidative Stress and Vasoconstriction for Treating Diabetic Nephropathy

Liu,

Pang,

Wang

et al. 2024

ACS Biomater. Sci. Eng.

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“…In a recent work reported by Pang et al , lutein and celastrol were loaded into chitosan via pH-sensitive citraconic anhydride linkers. 72 The renal protective ability of fabricated nanomicelles was verified in cisplatin-induced AKI models, via NFκB p65 and p38 mitogen-activated protein kinase (MAPK) inflammatory signaling pathways. Similarly, Wang et al conjugated the natural antioxidant curcumin to chitosan oligosaccharide (LMWC) for the treatment of lipopolysaccharide (LPS)-induced AKI.…”

Section: Natural Polymers For Renal-targeted Deliverymentioning

confidence: 99%

Natural products applied in acute kidney injury treatment: polymer matters

Yu,

Jin,

2024

Biomater. Sci.

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“…Curcumin, a well-known natural antioxidant, has a good ameliorating effect on oxidative stress induced by the toxic metal cadmium in the kidney when combined with chitosan nanoparticles. Similarly, M. Pang et al [ 94 ] used low-molecular-weight chitosan to encapsulate lutein and celastrol in order to prepare nanomicelles that could be delivered to the kidney for the treatment of acute kidney injury (AKI). Nano micelles measuring 75.0 ± 5.0 nm in size were created with a consistent spherical shape, a zeta potential of 20.0 ± 3.2 mV, and a polymer dispersity index (PDI) of 0.13 ± 0.05.…”

Section: Biopolymers and Their Application In Renal Diseasesmentioning

confidence: 99%

Biopolymer-Based Nanosystems: Potential Novel Carriers for Kidney Drug Delivery

Li,

Dai,

Xiao

et al. 2023

Pharmaceutics

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Kidney disease has become a serious public health problem throughout the world, and its treatment and management constitute a huge global economic burden. Currently, the main clinical treatments are not sufficient to cure kidney diseases. During its development, nanotechnology has shown unprecedented potential for application to kidney diseases. However, nanotechnology has disadvantages such as high cost and poor bioavailability. In contrast, biopolymers are not only widely available but also highly bioavailable. Therefore, biopolymer-based nanosystems offer new promising solutions for the treatment of kidney diseases. This paper reviews the biopolymer-based nanosystems that have been used for renal diseases and describes strategies for the specific, targeted delivery of drugs to the kidney as well as the physicochemical properties of the nanoparticles that affect the targeting success.

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Co-delivery of celastrol and lutein with pH sensitive nano micelles for treating acute kidney injury

Cited by 6 publications

References 53 publications

Intestinal Absorption of Nanoparticles to Reduce Oxidative Stress and Vasoconstriction for Treating Diabetic Nephropathy

Intestinal Absorption of Nanoparticles to Reduce Oxidative Stress and Vasoconstriction for Treating Diabetic Nephropathy

Natural products applied in acute kidney injury treatment: polymer matters

Biopolymer-Based Nanosystems: Potential Novel Carriers for Kidney Drug Delivery

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