Abstract:Hypoxia, an oxygen-deprived condition of the tumor, is one of the major reasons for resistance to chemotherapy. Carbonic anhydrases are generally involved in pH homeostasis in normal conditions, but in solid tumors having a strong relation with hypoxia, the carbonic anhydrase IX (CA-IX) enzyme is overexpressed and results in an extracellular acidic environment. For most weakly basic anticancer drugs, including doxorubicin (Dox), the ionization in an acidic environment limits their cellular uptake, and conseque… Show more
“…Moreover, the NPs that involve physical interactions to incorporate therapeutics agents might suffer from drug leakage, resulting in low drug loading and encapsulation efficiencies. [62][63][64] In the following sections, we will discuss the recent studies involving the use of different organic and inorganic NPs for the nanoformulation of GA, in an attempt to overcome the obstacles that hinder its application.…”
Section: Gambogic Acid Nano-delivery Using Nano-particulatesmentioning
Despite the advancements in cancer therapies during the past few years, chemo/photo resistance, severe toxic effects, recurrence of metastatic tumors, and non-selective targeting remain incomprehensible.
“…Moreover, the NPs that involve physical interactions to incorporate therapeutics agents might suffer from drug leakage, resulting in low drug loading and encapsulation efficiencies. [62][63][64] In the following sections, we will discuss the recent studies involving the use of different organic and inorganic NPs for the nanoformulation of GA, in an attempt to overcome the obstacles that hinder its application.…”
Section: Gambogic Acid Nano-delivery Using Nano-particulatesmentioning
Despite the advancements in cancer therapies during the past few years, chemo/photo resistance, severe toxic effects, recurrence of metastatic tumors, and non-selective targeting remain incomprehensible.
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