Co-delivery of a tumor microenvironment-responsive disulfiram prodrug and CuO₂ nanoparticles for efficient cancer treatment

Abstract

Disulfiram (DSF) has been used as a hangover drug for more than seven decades and was found to have potential in cancer treatment, especially mediated by copper. However, the uncoordinated...

Abnormal copper coordination obtained by a TiO2 overlayer as the key to enhance photocatalytic hydrogen generation

“…29,30 Although less explored in photocatalytic reactions, especially with TiO 2 -based photocatalysts, CuO 2 has been reported for fast charge transport, showing great potential in cuprate superconductor engineering, solid-state physics, and cancer treatment. 31–33 Herein, we identify CuO 2 as a highly effective candidate for photocatalytic hydrogen generation. Additionally, tuning the interfacial interaction by constructing a metal oxide–support interface facilitates the transport and prolongs the lifetime of charge carriers that play a pivotal role in photon-to-hydrogen conversion.…”