Co/Cu Co‐Catalyzed Carbonylation of Alkyl Iodides and Thioesters

Abstract

Inspired by the unique and ubiquitous nature of thioesters, great attention has been focused on the synthesis of thioesters. However, the harsh reaction conditions and equivalent oxidant required can still limit their applications. Here, a salcomine/IPrCuCl co‐catalyzed carbonylative thioalkylation of alkyl iodides using simple thioesters as a thiol surrogate is developed. This catalytic protocol displayed a good functional groups tolerance. The current work provides an inspiring example of the non‐nobel metal‐catalysed carbonylation for the synthesis of chalcogen‐containing compounds.

An Efficient Synthesis of Thioesters Starting from N‐Arylthiocarbamates and Indoles: A Newman‐Kwart‐Type Rearrangement

“…In many cases, thioesters are general synthesized using noble metals (palladium and rhodium) as catalysts and the toxic gas (CO) as a carbonyl source. [7][8][9] And thiols can also be used for nucleophilic reactants to obtain target thioesters. [10] However, this strategy normally uses corrosive and toxic dicarbonyl dichlorides, as well as skinty thiols.…”