Co-crystal of Tramadol-Celecoxib Versus Tramadol or Placebo for Acute Moderate-to-Severe Pain After Oral Surgery: Randomized, Double-Blind, Phase 3 Trial (STARDOM1)
Richard Langford,
Esther M. Pogatzki-Zahn,
Adelaida Morte
et al.
Abstract:Introduction
Co-crystal of tramadol-celecoxib (CTC) is the first analgesic co-crystal for acute pain. This completed phase 3 multicenter, double-blind trial assessed the efficacy and safety/tolerability of CTC in comparison with that of tramadol in the setting of moderate-to-severe pain up to 72 h after elective third molar extraction requiring bone removal.
Methods
Adults (
n
= 726) were assigned randomly to five groups (2:2:2:2:1): orally ad… Show more
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