Co‐circulation of multiple measles virus genotypes during an epidemic in France in 2008

Waku‐Kouomou, Diane; Freymuth, F.; Châtelet, Isabelle Parent du; Wild, T. F.; Horvat, Branka

doi:10.1002/jmv.21766

Cited by 24 publications

(12 citation statements)

References 34 publications

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“…This state borders Cameroon, where a 1997 lineage IV virus (HQ131960, Fig ) was reported (Kwiatek et al., ). It is tempting to think that viruses of lineage IV‐NigB were first introduced into Nigeria from Cameroon and then evolved into lineage IV‐NigA viruses due possibly to genetic drift following in‐country transmission, as has been suggested for measles viruses (Santibanez et al., ; Alla et al., ; Waku‐Kouomou et al., ). Further in‐depth genetic analysis using next‐generation sequencing is planned to confirm this hypothesis.…”

Section: Resultsmentioning

confidence: 99%

Co-circulation of Peste-des-Petits-Ruminants Virus Asian lineage IV with Lineage II in Nigeria

Woma

Adombi

et al. 2015

Transbound Emerg Dis

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Peste-des-petits-ruminants (PPR), a major small ruminant transboundary animal disease, is endemic in Nigeria. Strains of the causal agent, peste-des-petitsruminants virus (PPRV), have been differentiated into four genetically distinct lineages based on the partial sequence of the virus nucleoprotein (N) or fusion (F) genes. Peste-des-petits-ruminants virus strains that were identified initially in Africa were grouped into lineages I, II and III and viruses from Asia were classified as lineage IV and referred to as the Asian lineage. Many recent reports indicate that the Asian lineage is now also present in Africa. With this in mind, this study was conducted to reassess the epidemiology of PPRV in Nigeria. A total of 140 clinical samples from 16 sheep and 63 goats with symptoms suggestive of PPR were collected from different states of Nigeria during a four-year period (2010)(2011)(2012)(2013). They were analysed by the amplification of fragments of the N gene. Results for 33 (42%) animals were positive. The phylogenetic analysis of the N gene sequences with those available in GenBank showed that viruses that were detected belong to both lineage II and IV. Based on an analysis of the N gene sequences, the lineage IV isolates grouped into two clades, one being predominant in the north-eastern part of the country and the other found primarily in the southern regions of the country. This study reports the presence of PPRV Asian lineage IV in Nigeria for the first time.

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Section: Resultsmentioning

confidence: 99%

Co-circulation of Peste-des-Petits-Ruminants Virus Asian lineage IV with Lineage II in Nigeria

Woma

Adombi

et al. 2015

Transbound Emerg Dis

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“…The possibilities of missing genotypes or of importation of other genotypes must be further studied and documented with continuous countrywide molecular surveillance in India. Other countries have also documented co-circulation of genotypes, probably due to multiple chains of transmission during an outbreak [32,33]. …”

Section: Discussionmentioning

confidence: 99%

Identification of different lineages of measles virus strains circulating in Uttar Pradesh, North India

Shakya

Shukla

Maan

et al. 2012

Virol J

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BackgroundGenetic analysis of measles viruses associated with recent cases and outbreaks has proven to bridge information gaps in routine outbreak investigations and has made a substantial contribution to measles control efforts by helping to identify the transmission pathways of the virus.Materials and methodsThe present study describes the genetic characterization of wild type measles viruses from Uttar Pradesh, India isolated between January 2008 and January 2011. In the study, 526 suspected measles cases from 15 outbreaks were investigated. Blood samples were collected from suspected measles outbreaks and tested for the presence of measles specific IgM; throat swab and urine samples were collected for virus isolation and RT-PCR. Genotyping of circulating measles viruses in Uttar Pradesh was performed by sequencing a 450-bp region encompassing the nucleoprotein hypervariable region and phylogenetic analysis.Results and conclusionBased on serological results, all the outbreaks were confirmed as measles. Thirty eight strains were obtained. Genetic analysis of circulating measles strains (n = 38) in Uttar Pradesh from 235 cases of laboratory-confirmed cases from 526 suspected measles cases between 2008 and 2011 showed that all viruses responsible for outbreaks were within clade D and all were genotype D8.Analysis of this region showed that it is highly divergent (up to 3.4% divergence in the nucleotide sequence and 4.1% divergence in the amino acid sequence between most distant strains). Considerable genetic heterogeneity was observed in the MV genotype D8 viruses in North India and underscores the need for continued surveillance and in particular increases in vaccination levels to decrease morbidity and mortality attributable to measles.

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“…Patients in both cases presented with measles symptoms shortly after arriving in Turkey. BLAST and MeaNS analysis illustrated that the nucleotide sequences of these strains were identical to strains MV/Nantes.FRA/44.08 and MV/Montaigu.FRA/43.08 identified during an epidemic in 2008 in France [Waku‐Kouomou et al, ]. Sequences were also identical to strains MV/Falaise.FRA/16.10, MV/Paris.FRA/18.10 and MV/Lyon.FRA/03.11 identified during outbreaks in 2010 and 2011 in France (Fig.…”

Section: Resultsmentioning

confidence: 98%

Molecular characterization of measles viruses in Turkey (2010–2011): First report of genotype D9 involved in an outbreak in 2011

Kalaycioglu

Baykal²,

Güldemir³

et al. 2013

Journal of Medical Virology

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Genetic characterization of measles viruses (MVs) combined with acquisition of epidemiologic information is essential for measles surveillance programs used in determining transmission pathways. This study describes the molecular characterization of 26 MV strains (3 from 2010, 23 from 2011) obtained from urine or throat swabs harvested from patients in Turkey. MV RNA samples (n = 26) were subjected to sequence analysis of 450 nucleotides comprising the most variable C-terminal region of the nucleoprotein (N) gene. Phylogenetic analysis revealed 20 strains from 2011 belonged to genotype D9, 3 to D4, 2 strains from 2010 to genotype D4 and 1 to genotype B3. This study represents the first report describing the involvement of MV genotype D9 in an outbreak in Turkey. The sequence of the majority of genotype D9 strains was identical to those identified in Russia, Malaysia, Japan, and the UK. Despite lack of sufficient epidemiologic information, the presence of variants observed following phylogenetic analysis suggested that exposure to genotype D9 might have occurred due to importation more than once. Phylogenetic analysis of five genotype D4 strains revealed the presence of four variants. Epidemiological information and phylogenetic analysis suggested that three genotype D4 strains and one genotype B3 strain were associated with importation. This study suggests the presence of pockets of unimmunized individuals making Turkey susceptible to outbreaks. Continuing molecular surveillance of measles strains in Turkey is essential as a means of acquiring epidemiologic information to define viral transmission patterns and determine the effectiveness of measles vaccination programs designed to eliminate this virus.

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Co‐circulation of multiple measles virus genotypes during an epidemic in France in 2008

Cited by 24 publications

References 34 publications

Co-circulation of Peste-des-Petits-Ruminants Virus Asian lineage IV with Lineage II in Nigeria

Co-circulation of Peste-des-Petits-Ruminants Virus Asian lineage IV with Lineage II in Nigeria

Identification of different lineages of measles virus strains circulating in Uttar Pradesh, North India

Molecular characterization of measles viruses in Turkey (2010–2011): First report of genotype D9 involved in an outbreak in 2011

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