Co-biopolymer of chitosan/carboxymethyl cellulose hydrogel improved by zinc oxide and graphene quantum dots nanoparticles as pH-sensitive nanocomposite for quercetin delivery to brain cancer treatment

Ostovar, Shima; Pourmadadi, Mehrab; Zaker, Mohammad Amin

doi:10.1016/j.ijbiomac.2023.127091

Cited by 18 publications

(3 citation statements)

References 76 publications

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“…There is a wealth of literature reporting the antitumor properties of components like quercetin and Moracin A. [ 24 , 25 ] Given Morusin’s strong antioxidant and antiinflammatory capabilities, this study aims to explore the antitumor characteristics of Morusin. [ 26 ] The literature suggests that Mori Cortex can serve as a functional food/herbal remedy for the prevention of obesity and its associated metabolic diseases by regulating abnormal adipocyte metabolism involving the AMPK signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

Investigating the molecular mechanism of Mori Cortex against osteosarcoma by bioinformatics analysis and in vitro experimental

Wang,

Xie

et al. 2024

Medicine

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Objective: To explore the therapeutic mechanism of Mori Cortex against osteosarcoma (OS), we conducted bioinformatics prediction followed by in vitro experimental validation. Methods: Gene expression data from normal and OS tissues were obtained from the GEO database and underwent differential analysis. Active Mori Cortex components and target genes were extracted from the Traditional Chinese Medicine System Pharmacology database. By intersecting these targets with differentially expressed genes in OS, we identified potential drug action targets. Using the STRING database, a protein-protein interaction network was constructed. Subsequent analyses of these intersected genes, including Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathway enrichment, were performed using R software to elucidate biological processes, molecular functions, and cellular components, resulting in the simulation of signaling pathways. Molecular docking assessed the binding capacity of small molecules to signaling pathway targets. In vitro validations were conducted on U-2 OS cells. The CCK8 assay was used to determine drug-induced cytotoxicity in OS cells, and Western Blotting was employed to validate the expression of AKT, extracellular signal-regulated kinases (ERK), Survivin, and Cyclin D1 proteins. Results: Through differential gene expression analysis between normal and OS tissues, we identified 12,364 differentially expressed genes. From the TCSMP database, 39 active components and 185 therapeutic targets related to OS were derived. The protein-protein interaction network indicated that AKT1, IL-6, JUN, VEGFA, and CASP3 might be central targets of Mori Cortex for OS. Molecular docking revealed that the active compound Morusin in Mori Cortex exhibits strong binding affinity to AKT and ERK. The CCK8 assay showed that Morusin significantly inhibits the viability of U-2 OS cells. Western Blot demonstrated a reduction in the p-AKT/AKT ratio, the p-ERK/ERK ratio, Survivin, and Cyclin D1. Conclusion: Mori Cortex may exert its therapeutic effects on OS through multiple cellular signaling pathways. Morusin, the active component of Mori Cortex, can inhibit cell cycle regulation and promote cell death in OS cells by targeting AKT/ERK pathway.

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Section: Discussionmentioning

confidence: 99%

Investigating the molecular mechanism of Mori Cortex against osteosarcoma by bioinformatics analysis and in vitro experimental

Wang,

Xie

et al. 2024

Medicine

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“…Examples of carboxymethylcellulosebased nanocomposites investigated as carriers of selected active substances are indicated in Table 3. Tetracycline Antibiotic Nanocomposite based on carboxymethyl cellulose containing Zn-melamine and Cu-melamine framework [147] Diclofenac sodium Nonsteroidal anti-inflammatory drug Nanocomposite based on poly(methacrylic acid) crosslinked with carboxymethyl cellulose and incorporated with in situ-formed silver nanoparticles [148] Cellulose, while biocompatible and biodegradable, may exhibit a limited ability to release the active substances in a controlled manner. It can also be problematic to maintain the structural stability of cellulose-based carriers, especially under changing conditions of the biological environment, which affects their drug delivery efficiency.…”

Section: Cellulose-based Nanocomposite Carriersmentioning

confidence: 99%

Advanced Drug Carriers: A Review of Selected Protein, Polysaccharide, and Lipid Drug Delivery Platforms

Jamroży,

Kudłacik-Kramarczyk,

Drabczyk

et al. 2024

IJMS

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Studies on bionanocomposite drug carriers are a key area in the field of active substance delivery, introducing innovative approaches to improve drug therapy. Such drug carriers play a crucial role in enhancing the bioavailability of active substances, affecting therapy efficiency and precision. The targeted delivery of drugs to the targeted sites of action and minimization of toxicity to the body is becoming possible through the use of these advanced carriers. Recent research has focused on bionanocomposite structures based on biopolymers, including lipids, polysaccharides, and proteins. This review paper is focused on the description of lipid-containing nanocomposite carriers (including liposomes, lipid emulsions, lipid nanoparticles, solid lipid nanoparticles, and nanostructured lipid carriers), polysaccharide-containing nanocomposite carriers (including alginate and cellulose), and protein-containing nanocomposite carriers (e.g., gelatin and albumin). It was demonstrated in many investigations that such carriers show the ability to load therapeutic substances efficiently and precisely control drug release. They also demonstrated desirable biocompatibility, which is a promising sign for their potential application in drug therapy. The development of bionanocomposite drug carriers indicates a novel approach to improving drug delivery processes, which has the potential to contribute to significant advances in the field of pharmacology, improving therapeutic efficacy while minimizing side effects.

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“…Furthermore, it was determined that CS/CMC/GQDs/ZnO@QUR nanocomposites exhibit minimal cytotoxicity towards L929 cell lines, as evidenced by an 85% cell viability rate. 103 In a recent study, Jastrzębska et al detailed the toxicological investigation of compounds connected to graphene. 104 It is noteworthy to mention that several studies have found that GQDs are less hazardous than GO and that this may be because of the way their tiny size and quick clearance minimize damage to cell membranes.…”

Section: Gqdsmentioning

confidence: 99%

Recent advances in synergistic use of GQD-based hydrogels for bioimaging and drug delivery in cancer treatment

Akmal,

Kalashgrani,

Mousavi

et al. 2024

J. Mater. Chem. B

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Co-biopolymer of chitosan/carboxymethyl cellulose hydrogel improved by zinc oxide and graphene quantum dots nanoparticles as pH-sensitive nanocomposite for quercetin delivery to brain cancer treatment

Cited by 18 publications

References 76 publications

Investigating the molecular mechanism of Mori Cortex against osteosarcoma by bioinformatics analysis and in vitro experimental

Investigating the molecular mechanism of Mori Cortex against osteosarcoma by bioinformatics analysis and in vitro experimental

Advanced Drug Carriers: A Review of Selected Protein, Polysaccharide, and Lipid Drug Delivery Platforms

Recent advances in synergistic use of GQD-based hydrogels for bioimaging and drug delivery in cancer treatment

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