Co-Axial Fibers with Janus-Structured Sheaths by Electrospinning Release Corn Peptides for Wound Healing

Abstract

Delayed wound healing in skin is strongly correlated with excessive reactive oxygen species (ROS) generation. Corn peptides (CPs) have robust antioxidant and anti-inflammatory effects. Therefore, the study sought to evaluate the wound healing effect of topical application of CPs embedded in wound dressings fabricated using the coaxial electrospinning technique. A special structure, which was a co-axial structure with a Janus-structured sheath, was displayed on the fiber. The fibers exhibited stable thermal properties, suitable tensile properties, high wettability, excellent biocompatibility, and free radical scavenging capability. Additionally, a first-order release profile of CPs from the fibers showed that approximately 92% of the drug was released within 80 min. In vivo experiments indicated that CPs-loaded fibrous membranes significantly improved the wound healing ratio, thickened the re-epithelialization layer, enhanced fibroblast proliferation, and increased the production of regenerated hair follicles and capillaries. Overall, it is promising that the combination of CPs and fibrous membranes with special structures applies in skin tissue engineering to promote wound repair.

A periodontal tissue regeneration strategy via biphasic release of zeolitic imidazolate framework-8 and FK506 using a uniaxial electrospun Janus nanofiber

“…1D) clearly showed a cracked surface and hollow inside (yellow arrows), which is attributed to the different surface properties of the Janus nanofibers as our previous research reported. 32,33 Briefly, after soaking in water, the hydrophobic PCL component of the nanofibers remained intact and the hydrophilic PVP component was degraded. 002), ( 112), ( 022), (013), and (222), indicating that the ZIF-8 NPs were dispersed in the nanofibers.…”

“…31 In our previous study, we produced Janus nanofibers taking advantage of the phase separation in polycaprolactone (PCL) and polyvinylpyrrolidone (PVP) solution by uniaxial electrospinning. 32,33 PCL is a biodegradable polymer with good mechanical properties, the hydrophobic nature of which allows the cargo to be released continuously. 34,35 PVP is a synthetic water-soluble polymer that has been applied as a fastdissolving matrix carrier in various drug delivery systems.…”

Functionalized Antimicrobial Nanofibers: Design Criteria and Recent Advances

“…Meanwhile, emulsion electrospinning involves two immiscible phases of polymers and a therapeutic agent, whereby the agent can be encapsulated throughout the nanofibers matrix or encapsulated in the core-shell nanofibers [ 131 , 132 , 133 ]. Co-axial electrospinning uses two nozzles containing the polymer solution and the therapeutic agent separately, to produce a core-shell structure in the nanofibers [ 134 , 135 , 136 , 137 ]. Usually, the polymer matrix will provide the outer core, while the therapeutic agent is incorporated in the inner core of the nanofibers [ 27 , 138 ].…”

Sandwich structure Aloin-PVP/Aloin-PVP-PLA/PLA as a wound dressing to accelerate wound healing

“…[24][25][26] These dressings have ductility and tensile strength comparable to human skin, so they can t the wound well. 27 Meanwhile, the electrospinning nanober membrane also has the characteristics of the three-dimensional support structure, small pore size and high surface area to volume ratio. 28 To a certain extent, the designed electrospinning nanober membranes can be used to simulate the biological functions of extracellular matrix (ECM) and provide an ideal microenvironment for cell adhesion, proliferation and further differentiation.…”