Co-assembly of polyoxometalates and peptides towards biological applications

Gao, Peng-Fan; Wu, Yuqing; Wu, Lixin

doi:10.1039/c6sm01433j

Cited by 42 publications

(26 citation statements)

References 141 publications

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“…The formation of such smaller aggregates with 1.Co II in the presence of 1-bromopyrene may also accounts for the lower incorporation of the polyaromatic guest. Owing to the well-known bioactivity of POMs ( 33 – 35 ), these aqueous soluble nanoobjects further displaying molecular carrier properties (drug delivery) hold great promise for biological applications.…”

Section: Resultsmentioning

confidence: 99%

Control of the hierarchical self-assembly of polyoxometalate-based metallomacrocycles by redox trigger and solvent composition

Piot

Abécassis

Brouri

et al. 2018

Proc. Natl. Acad. Sci. U.S.A.

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SignificanceHierarchical self-assembly is a powerful route allowing the elaboration of complex supramolecular architectures with emergent structuration or properties. Starting from well-defined molecular building units, this synthetic strategy relies on the construction of a preassembled structural motif that can further self-assemble through additional noncovalent interactions. In this context, we developed a system based on a covalent organic–inorganic polyoxometalate hybrid building block combining metal-driven self-assembly and electrostatic interactions. We herein show that in this system, the supramolecular organization can be controlled by a redox stimulus and/or the solvent composition giving rise to various types of nanoarchitectures from discrete metallomacrocycles to 1D worm-like nanoobjects.

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Section: Resultsmentioning

confidence: 99%

Control of the hierarchical self-assembly of polyoxometalate-based metallomacrocycles by redox trigger and solvent composition

Piot

Abécassis

Brouri

et al. 2018

Proc. Natl. Acad. Sci. U.S.A.

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“…Peptides are suitable pendants for POMs and can be covalently grafted via amide bonds . On the other hand, as observed for the targeted proteins mentioned above, they can also establish multiple weak interactions with the POM surface, being these usually more efficient upon increasing of size and charge density of the polyanion, or when using transition metal‐substituted POMs with free coordination positions on the metal ions …”

Section: Introductionmentioning

confidence: 99%

Synthesis and biological activity of an Anderson polyoxometalate bis‐functionalized with a Bombesin‐analog peptide

Ventura

Calderan²,

Honisch³

et al. 2018

Peptide Science

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Polyoxometalates (POMs) are multi metallic and polyanionic oxides whose functionalization with organic moieties can generate new properties. Among possible strategies to generate molecular diversity and find applications in different fields, the postfunctionalization of a POM with peptides is particularly interesting and easily achievable. In this article, we present the functionalization of the Anderson‐Evans polyoxomolybdate ([MnMo6O24]3–) with a Bombesin antagonist peptide, to highlight the interplay between these 2 domains, in terms of structural changes and assembly. Moreover, since Bombesin analogs show a marked binding affinity and specificity for some subtypes of the Gastrin Releasing Peptide Receptor (GRP‐R), the impact of the peptide on the antitumor activity of the Anderson‐Evans polyoxomolybdate POM has been explored.

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“…[234][235][236] On the other hand, the self-assembly structures and synergistic properties could be envisioned. [237][238][239] In an earlier work, Hill and coworkers found that POMs had strong propensity to bind at the cationic pocket of HIV-1 protease, resulting in the deactivation of the enzyme. [240] Drawing inspiration from this work, intensively efforts have been devoted to develop POM-based enzyme inhibitors by electrostatical covering the nanosized POMs at the active site of different enzymes.…”

Section: Cationic Peptides and Polyoxometalatesmentioning

confidence: 99%

Recent Progress in Ionic Coassembly of Cationic Peptides and Anionic Species

Xie

Zheng

2020

Macromol. Rapid Commun.

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innovative insight into understanding the properties of the material systems beyond molecular level. [6-8] Through the last decades, supramolecular chemistry has deeply permeated and fused with biology and materials science, and has gradually growth into an interdisciplinary platform for the creation of self-assembled systems with extraordinary properties. [9-12] Among the numerous systems, self-assembled peptide is one of the most important branches, because of its rich chemical diversity, versatile characters, inherent biocompatibility, and bioactivity. [13-15] Specifically, the natural or chemically engineered amino acids encoded in the sequence of peptide molecules enable the formation of customizable secondary structures, the cooperative interactions between main chains and side chains of peptide molecules can be further leveraged to produce hierarchical nanostructures [16-22] and important biofunctions, such as drug delivery, [23-25] tissue engineering, [26-28] regenerative medicine, [29-31] and biomineralization. [32-35] Moreover, many studies have disclosed that self-assembled peptide nanostructures can offer higher performance (catalytic, therapeutic, targeting, etc.) than peptide itself. [36-42] For those reasons, peptide self-assembly has been recognized as a subject of great importance in supramolecular chemistry, biology, and nanotechnology, and the breadth and depth of peptide selfassemblies have been documented and demonstrated in several excellent reviews. [43-51] Besides the self-assembly of unimolecular peptides, multicomponent coassembly between peptides and other building blocks has recently become increasingly prevalent, as the modular approach offers a simple and effective way to arrive at supramolecular materials with wide structural complexity and value-added properties for multiple tasks applications. [52-56] This integrated characteristic further stimulates researchers to explore the scope of peptide coassembly with the aim of expanding the space of functional utility. To selectively form the multicomponent nanostructures, the interplay of the driving forces should be energetically much more favorable for strengthening the coassembly of distinct components than the self-sorting of the same type of components. [57-59] Following this design criteria, the introduction of complementary noncovalent interactions into the multicomponent systems is Peptide assembly has been extensively exploited as a promising platform for the creation of hierarchical nanostructures and tailor-made bioactive materials. Ionic coassembly of cationic peptides and anionic species is paving the way to provide particularly important contribution to this topic. In this review, the recent progress of ionic coassembly soft materials derived from the electrostatic coupling between cationic peptides and anionic species in aqueous solution is systematically summarized. The presentation of this review starts from a brief background on the general importance and advantages of peptide-based ionic coassembly. After that, divers...

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Co-assembly of polyoxometalates and peptides towards biological applications

Cited by 42 publications

References 141 publications

Control of the hierarchical self-assembly of polyoxometalate-based metallomacrocycles by redox trigger and solvent composition

Control of the hierarchical self-assembly of polyoxometalate-based metallomacrocycles by redox trigger and solvent composition

Synthesis and biological activity of an Anderson polyoxometalate bis‐functionalized with a Bombesin‐analog peptide

Recent Progress in Ionic Coassembly of Cationic Peptides and Anionic Species

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