Co-assembled Supramolecular Hydrogel of Salvianolic Acid B and a Phosphopeptide for Enhanced Wound Healing

Abstract

Supramolecular natural product gels (NPGs) have emerged as promising biomaterials for scalable and adjustable drug delivery systems. These gels possess biocompatibility, biodegradability, and the ability to mimic the extracellular matrix. Salvianolic acid B (SAB), derived from Salvia miltiorrhiza, a Chinese medicinal plant, exhibits various beneficial properties such as antioxidant, antifibrotic, and angiogenic effects. In our research, we serendipitously discovered that the co-assembly of SAB and a soluble phosphopeptide results in the formation of a robust and adhesive hydrogel termed 1&SAB hydrogel. This hydrogel effectively prolongs the retention time of the therapeutic agents on the skin's wound surface, thereby promoting wound healing. The hydrogel demonstrates antioxidant effects, enhances cell migration, accelerates angiogenesis, and inhibits scar hyperplasia. This innovative gel material offers a simple and efficient approach to managing skin wounds and holds promise for application in complex wound-healing treatments.

Collision of herbal medicine and nanotechnology: a bibliometric analysis of herbal nanoparticles from 2004 to 2023

“…Compared to free drugs, these hydrogels more readily enter cells, subsequently achieving anti-neuroinflammatory therapy by inhibiting the Toll-like receptor 4/nuclear factor-κB signaling pathway [ 162 ]. In another study, salvianolic acid B and NapFFKYp could form a spontaneous hydrogel that promoted wound healing [ 163 ].…”

Stimuli-responsive peptide hydrogels for biomedical applications

“…Huang et al co-assembled salvianolic acid B (SAB) and a soluble phosphopeptide to design a robust and adhesive non-covalently crosslinked hydrogel called 1&SAB. 147 This hydrogel possesses antioxidant properties, enhances cell migration, accelerates angiogenesis, and prolongs the residence time of therapeutic agents on skin wound surfaces, thereby promoting wound healing. Xing et al designed a chiral non-covalently crosslinked hydrogel dressing (HA-LM2-RMR) composed of l-phenylalanine and cationic hexapeptide co-assembled helical nanofibers cross-linked with hyaluronic acid via hydrogen bonding.…”

Injectable Hydrogels Based on Hyaluronic Acid and Gelatin Combined with Salvianolic Acid B and Vascular Endothelial Growth Factor for Treatment of Traumatic Brain Injury in Mice

“…Salvianolic acid B (SAB) has been widely used for neuroprotection and recovery treatment after brain injury due to its anti-inflammatory, anti-oxidation, and angiogenesis effects [34][35][36]. Our previous studies have shown that the combination of SAB in HA hydrogel can promote wound healing via anti-inflammatory and pro-angiogenic effects [37][38][39]. In addition, SAB-loaded hydrogel can effectively improve blood supply and inhibit extracellular matrix degradation after myocardial infarction [40].…”