Co-administration of omega-3 fatty acids and metformin showed more desirable effects than the single therapy on indices of bone mineralisation but not gluco-regulatory and antioxidant markers in diabetic rats

Adeyemi, Wale Johnson; Olayaki, Luqman Aribidesi; Abdussalam, Tahir Ahmad; Fabiyi, Tolulope Olaoluwa; Raji, Temidayo Luqman; Adetunji, Adenike Amatur-Rahman

doi:10.1016/j.biopha.2019.109631

Cited by 11 publications

(5 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the current study, the results of H&E and Oil Red O staining data demonstrated that the lipid droplets in the hepatocytes of mice shrank in the GLP groups compared with the model control group, which indicated that fatty liver induced by diabetes was significantly improved by GLP treatment. The present study was accompanied with a positive control, MET, which has been used to effectively treat T2DM (40). Notably, nearly all the indexes measured showed that 400 mg/kg GLP exerted a similar anti-diabetic effect as 300 mg/kg MET.…”

Section: Discussionmentioning

confidence: 82%

Significant effects of Ganoderma lucidum polysaccharide on lipid metabolism in diabetes may be associated with the activation of the FAM3C‑HSF1‑CAM signaling pathway

2021

View full text Add to dashboard Cite

Diabetes is a threat to patient health worldwide. Type 2 diabetes (T2DM), one of the two main types of diabetes, is a long-term metabolic disease caused by heredity and environmental factors. It has been reported that Ganoderma lucidum polysaccharide (GLP) significantly decreased the concentration of blood glucose, promoted insulin secretion, improved glucose tolerance and regulated the concentration of blood lipids. In the present study, a T2DM model was established in db/db mice, following which T2DM mice were treated with GLP (100 and 400 mg/kg) for 8 weeks, with MET used as the positive control. The glycosylated hemoglobin (HbAlc) and fasting blood glucose (FBG) levels, and diabetes-associated clinical chemistry indexes were detected in the blood and serum of each mouse. Hematoxylin and eosin, and oil red O staining were performed on the livers of each mouse to evaluate the level of liver fat. The expression levels of family with sequence similarity 3 (FAM3C), heat shock factor 1 (HSF1), calmodulin (CaM), AKT and phosphorylated (p)-AKT were detected in the hepatocytes of T2DM mice using reverse transcription-quantitative PCR and western blotting. The results demonstrated that the unbalanced levels of HbAlc, FBG and diabetes-related index in T2DM mice were significantly improved by treatment with GLP. Lipid droplets in the hepatocytes of mice shrank in the GLP groups compared with the model control group. The expression levels of FAM3C, HSF1, CaM and p-AKT/AKT in the hepatocytes of T2DM mice were significantly increased following treatment with GLP. In conclusion, GLP exerted significant effects on lipid metabolism in diabetes, which may be associated with the activation of the FAM3C-HSF1-CaM signaling pathway.

show abstract

Section: Discussionmentioning

confidence: 82%

Significant effects of Ganoderma lucidum polysaccharide on lipid metabolism in diabetes may be associated with the activation of the FAM3C‑HSF1‑CAM signaling pathway

2021

View full text Add to dashboard Cite

show abstract

“…Despite this promising potential and similar to the case of other drug carriers, Alg-based fibers documented in the literature have been reported predominately for delivery of single agents till now [23] , [24] , [25] , [26] . As a matter of fact, while the “single molecule, single target, and single drug" approach has dominated for most of the 20th century [27] , multi-drug therapy has gained increasing attention due to its potential of boosting the therapeutic efficiency beyond that of a single drug [28] , [29] , [30] . Although few efforts in the literature have attempted to mix and load different drugs into a single system (ranging from polymeric micelles [31 , 32] and metal-organic frameworks [33] to hydrogels [34 , 35] ) for co-delivery of multiple drugs, most of these efforts fail to enable precise manipulation of the release rate of each of the co-delivered drugs because changing the release sustainability of the system for one drug leads to changes in the release profile of the other.…”

Section: Introductionmentioning

confidence: 99%

Alginate‐based complex fibers with the Janus morphology for controlled release of co‐delivered drugs

Lai

Huang

Lui

2021

Asian Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

Hydrogels are soft materials consisting of a three-dimensional network of polymer chains. Over the years, hydrogels with different compositions have been developed as drug carriers for diverse biomedical applications, ranging from cancer therapy and wound care to the treatment of neurodegenerative and inflammatory diseases. Most of these carriers, however, are designed only to deliver single agents. Carriers based on hydrogels for co-delivery of multiple agents, with the release rate of each of the co-delivered agents tunable, are lacking. This study reports a one-pot method of fabricating alginate-based complex fibers with the Janus morphology, with carboxymethyl cellulose sodium functioning as a polymeric modifier of the properties of each of the fiber compartments. By using malachite green and minocycline hydrochloride as model drugs, the generated fibers demonstrate the capacity of enabling the release profile of each of the co-delivered drugs to be precisely controlled. Along with their negligible toxicity and the retention of the activity of the loaded drugs, the complex fibers reported in this study warrant further development and optimization for applications that involve co-delivery of multiple agents.

show abstract

“…As a result, the prevailing free radicals could no doubt instigate some degree of lipid peroxidation, which was indicated by the significant elevation in MDA level above the basal level even after treatment with Mel. The level of activity of LDH across the groups corresponded with that of MDA (Adeyemi and Olayaki, 2018a; Adeyemi et al, 2019, 2020a, 2020b, 2020c). Reduction in the peroxidation of cell membrane lipids after Mel administration resulted in cells preservation, which was indicated by the reduction in the activity of LDH, an enzyme that is known to be elevated following cellular or tissue damage and death (Shi et al, 2003).…”

Section: Discussionmentioning

confidence: 85%

Elevated, sustained, and yet reversible biotoxicity effects of lead on cessation of exposure: Melatonin is a potent therapeutic option

et al. 2020

Self Cite

View full text Add to dashboard Cite

Melatonin (Mel) is known to prevent and mitigate lead (Pb)-induced gonadotoxicity. However, there is no report in literature on the endogenous levels of different biomarkers after the cessation of Pb exposure, with or without treatment with Mel. Fifty adult male Wistar rats were divided into five groups ( N = 10), which included control ((vehicle (normal saline) - treated) − 0.1 ml/day); lead chloride (PbCl2) untreated (3 weeks vehicle + 3 weeks Pb); Pb recovery (3 weeks Pb + 3 weeks vehicle); Pb + Mel (3 weeks Pb + 3 weeks Mel); and Mel (3 weeks vehicle + 3 weeks Mel) groups. Pb and Mel were administered at 50 and 10 mg/kg B.W. ( p.o.), respectively. The results showed that Pb caused significant decreases in total bilirubin (TB), phospholipids (PLP), superoxide dismutase (SOD), catalase (CAT), and total antioxidant capacity (TAC), but significant elevations in alkaline phosphatase (ALP), aspartate aminotransferase (AST), triglyceride (TG), and malondialdehyde (MDA). Although the adverse effects of Pb on TB, ALP, AST, SOD, MDA, and TAC were sustained after the cessation of exposure, a reversal was observed in total cholesterol (TC), TG, PLP, CAT, and c-reactive protein (CRP) results. Nevertheless, the detrimental effects of Pb on alanine aminotransferase (ALT), albumin, and globulin were only expressed post-exposure. Treatment with Mel caused no significant effect on TB and albumin levels. However, unlike TAC and CRP, the hormone significantly reduced ALP, AST, ALT, TC, low-density lipoprotein cholesterol, PLP, SOD, CAT, MDA, and globulin to levels comparable to the control group. In conclusion, following the cessation of Pb exposure, alterations in physiological balance could be elevated, sustained, or reversible. However, Mel enhanced the reestablishment homeostatic status after Pb administration.

show abstract

Co-administration of omega-3 fatty acids and metformin showed more desirable effects than the single therapy on indices of bone mineralisation but not gluco-regulatory and antioxidant markers in diabetic rats

Cited by 11 publications

References 55 publications

Significant effects of Ganoderma lucidum polysaccharide on lipid metabolism in diabetes may be associated with the activation of the FAM3C‑HSF1‑CAM signaling pathway

Significant effects of Ganoderma lucidum polysaccharide on lipid metabolism in diabetes may be associated with the activation of the FAM3C‑HSF1‑CAM signaling pathway

Alginate‐based complex fibers with the Janus morphology for controlled release of co‐delivered drugs

Elevated, sustained, and yet reversible biotoxicity effects of lead on cessation of exposure: Melatonin is a potent therapeutic option

Contact Info

Product

Resources

About