Co-administration of Nanowired Oxiracetam and Neprilysin with Monoclonal Antibodies to Amyloid Beta Peptide and p-Tau Thwarted Exacerbation of Brain Pathology in Concussive Head Injury at Hot Environment

Nozari, Ala; Sharma, Aruna; Wang, Zhenguo; Feng, Lianyuan; Mureșanu, Dafin F.; Tian, Z. Ryan; Lafuente, José Vicente; Wiklund, Lars; Sharma, Hari Shanker

doi:10.1007/978-3-031-32997-5_7

Cited by 1 publication

(1 citation statement)

References 255 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other scientists employed several biomarkers to evaluate the effects of the treatment strategy on brain pathology and neuroprotection. [ 57 ] The study focused on biomarkers associated with Alzheimer’s disease, including amyloid beta peptide and phosphorylated tau, both of which are key players in the pathological process. In addition, the study likely assessed markers of inflammation, oxidative stress, and neuronal damage to understand the broader impact of the treatment.…”

Section: Evaluating Neuroprotection Outcomesmentioning

confidence: 99%

Neuroprotection: Surgical approaches in traumatic brain injury

Buccilli,

Alan,

Aljeradat

et al. 2024

Surgical Neurology International

View full text Add to dashboard Cite

Background: This review is centered on the pivotal role of surgical interventions within the comprehensive management of traumatic brain injury (TBI). Surgical strategies are indispensable components of TBI care, encompassing primary injury management and the alleviation of secondary injury processes, including the handling of intracranial hemorrhages (ICHs), contusions, and mass lesions. Methods: A systematic review was carried out by searching databases including PubMed, Embase, and Scopus. The inclusion criteria involved studies discussing surgical strategies for TBI, with a focus on primary injury management, ICHs, contusions, and mass lesions. More recent articles were prioritized, and data were synthesized to assess the impact of surgical interventions on TBI outcomes. Results: The evolution of surgical technologies has heralded a transformation in TBI management. These advancements encompass minimally invasive procedures, neuroimaging-guided surgeries, and robotic-assisted techniques, all geared toward optimizing patient outcomes. Conclusion: Surgical interventions within TBI care present unique challenges, such as timing considerations, patient selection criteria, and postoperative care. This review underscores the critical significance of multidisciplinary collaboration among neurosurgeons, neurologists, and critical care specialists. Such collaboration is essential to tailor surgical strategies to the individualized needs of patients. Moreover, the review highlights emerging trends in TBI surgery and underscores the ongoing imperative of research endeavors aimed at refining surgical protocols and ultimately enhancing patient outcomes.

show abstract

Section: Evaluating Neuroprotection Outcomesmentioning

confidence: 99%