Co-Administration of Nanowired Monoclonal Antibodies to Inducible Nitric Oxide Synthase and Tumor Necrosis Factor Alpha Together with Antioxidant H-290/51 Reduces SiO2 Nanoparticles-Induced Exacerbation of Pathophysiology of Spinal Cord Trauma

Sharma, Aruna; Mureșanu, Dafin F.; Tian, Zheng; Nozari, Ala; Lafuente, José Vicente; Sjöquist, Per-Ove; Feng, Lianyuan; Wiklund, Lars; Sharma, Hari Shanker

doi:10.1007/978-3-031-32997-5_5

Advances in Neurobiology

2023

DOI: 10.1007/978-3-031-32997-5_5

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Co-Administration of Nanowired Monoclonal Antibodies to Inducible Nitric Oxide Synthase and Tumor Necrosis Factor Alpha Together with Antioxidant H-290/51 Reduces SiO2 Nanoparticles-Induced Exacerbation of Pathophysiology of Spinal Cord Trauma

Aruna Sharma

Dafin F. Mureșanu

Zheng Tian

et al.

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The probable role of tissue plasminogen activator/neuroserpin axis in Alzheimer’s disease: a new perspective

Ali,

Al-kuraishy,

Al-Gareeb

et al. 2023

Acta Neurol Belg

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Alzheimer’s disease (AD) is the most common type of dementia associated with amyloid beta (Aβ) deposition. Dysfunction of the neuronal clearance pathway promotes the accumulation of Aβ. The plasminogen-activating system (PAS) is controlled by various enzymes like tissue plasminogen activators (tPA). Neuronal tPA enhances the conversion of plasminogen to plasmin, which cleaves Aβ; this function is controlled by many inhibitors of PAS, including a plasminogen-activating inhibitor (PAI-1) and neuroserpin. Therefore, the objective of the present narrative review was to explore the potential role of tPA/neuroserpin in the pathogenesis of AD. PAI-1 activity is increased in AD, which is involved in accumulating Aβ. Progressive increase of Aβ level during AD neuropathology is correlated with the over-production of PAI-1 with subsequent reduction of plasmin and tPA activities. Reducing plasmin and tPA activities promote Aβ by reducing Aβ clearance. Neuroserpin plays a critical role in the pathogenesis of AD as it regulates the expression and accumulation of Aβ. Higher expression of neuroserpin inhibits the neuroprotective tPA and the generation of plasmin with subsequent reduction in the clearance of Aβ. These observations raise conflicting evidence on whether neuroserpin is neuroprotective or involved in AD progression. Thus, neuroserpin over-expression with subsequent reduction of tPA may propagate AD neuropathology. Graphical abstract

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The probable role of tissue plasminogen activator/neuroserpin axis in Alzheimer’s disease: a new perspective

Ali,

Al-kuraishy,

Al-Gareeb

et al. 2023

Acta Neurol Belg

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Co-Administration of Nanowired Monoclonal Antibodies to Inducible Nitric Oxide Synthase and Tumor Necrosis Factor Alpha Together with Antioxidant H-290/51 Reduces SiO2 Nanoparticles-Induced Exacerbation of Pathophysiology of Spinal Cord Trauma

Cited by 1 publication

References 160 publications

The probable role of tissue plasminogen activator/neuroserpin axis in Alzheimer’s disease: a new perspective

The probable role of tissue plasminogen activator/neuroserpin axis in Alzheimer’s disease: a new perspective

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