Co-administration of Bacillus subtilis RJGP16 and Lactobacillus salivarius B1 strongly enhances the intestinal mucosal immunity of piglets

Deng, Jun; Li, Yunfeng; Zhang, Jinhua; Yang, Qian

doi:10.1016/j.rvsc.2012.07.025

Cited by 53 publications

(47 citation statements)

References 40 publications

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“…Several mechanisms, including changes in the cytokine gene expression of the host, may be behind these effects. Although alterations in cytokine mRNA levels in the porcine intestinal mucosa after bacterial supplementation have been reported in some previous studies (Walsh et al, 2008;Zhang et al, 2011;Deng et al, 2013), there is still very limited information available about the effects of potential probiotics on the intestinal cytokine expression in pigs. In this study, the lactobacilli supplementation also showed immunomodulatory effects in the intestinal mucosa of the piglets, with these effects being localized mainly in the large intestine.…”

Section: Discussionmentioning

confidence: 98%

Effect of a multispecies lactobacillus formulation as a feeding supplement on the performance and immune function of piglets

et al. 2015

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Section: Discussionmentioning

confidence: 98%

Effect of a multispecies lactobacillus formulation as a feeding supplement on the performance and immune function of piglets

et al. 2015

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“…Deng et al [63] (2013) evaluated the ability of the coadministration of Bacillus subtillis RJGP16 and Lactobacillus salivarius B1 to stimulate local immune responses. Thirty two newborn piglets were divided into four groups and were orally administered with different combinations of probiotics (none; RJGP16; B1; RJGP16 and B1) at the ages of 0, 7 and 11 d. These authors analyzed the parameters of the mucosal immunity of piglets one week after weaning.…”

Section: Animal Studiesmentioning

confidence: 99%

“…bulgaricus TLR-4, p38, and Iκ B Animal studies Matsumoto et al [57] B. animalis subsp. lactis LKM512 Aging-associated and inflammation-associated genes Ohtsuka et al [58] B. breve M-16V LBP Trevisi et al [59] B. animalis TLR-2 and TLR-4 Dykstra et al [60] Bifidobacteria and lactobacilli MUC2, MUC3, NAIP, HIAP1/cIAP2, and HIAP2/cIAP1 Foye et al [62] L. acidophilus IL-10 and TGF-β Deng et al [63] B. subtillis RJGP16 and L. salivarius B1 IL-6 and pBD-2 Jain et al [64] L. casei IFN-γ and IL-2 Pérez-Sánchez et al [65] L. plantarum, L. lactis, and L. mesenteroides IL-1β, IL-8, IL-10, TNF-α, IL-8, TLR5, and IgT Pirarat et al [66] L. rhamnosus GG TNF-α and IL-1 Human studies van Baarlen et al [67] L. acidophilus, L. casei, and L. rhamnosus Gene-regulatory networks and pathways in human mucosa Lammers et al [68] VSL#3 IL-1β, IL-6, IFN-γ, TNF-α, IL-12, IL-10, TGF-β, and IL-8 Di Caro et al [69] B. clausii Genes involved in the immune response and inflammation translocation of NF-κB, as demonstrated by a decrease in the expression of MyD88, IRAK-1, IκBα, the nuclear NF-κB p50/p65 subunits, p-p38 MAPK and p-MEK1 and the NF-κB-dependent luciferase reporter gene activity in LPS-stimulated cells [72] .…”

Section: Probiotic Strain Genes Involvedmentioning

confidence: 99%

Modulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver by probiotics

Plaza‐Díaz¹

2014

WJG

177

120

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The potential for the positive manipulation of the gut microbiome through the introduction of beneficial microbes, as also known as probiotics, is currently an active area of investigation. The FAO/WHO define probiotics as live microorganisms that confer a health benefit to the host when administered in adequate amounts. However, dead bacteria and bacterial molecular components may also exhibit probiotic properties. The results of clinical studies have demonstrated the clinical potential of probiotics in many pathologies, such as allergic diseases, diarrhea, inflammatory bowel disease and viral infection. Several mechanisms have been proposed to explain the beneficial effects of probiotics, most of which involve gene expression regulation in specific tissues, particularly the intestine and liver. Therefore, the modulation of gene expression mediated by probiotics is an important issue that warrants further investigation. In the present paper, we performed a systematic review of the probiotic-mediated modulation of gene expression that is associated with the immune system and inflammation. Between January 1990 to February 2014, PubMed was searched for articles that were published in English using the MeSH terms "probiotics" and "gene expression" combined with "intestines", "liver", "enterocytes", "antigen-presenting cells", "dendritic cells", "immune system", and "inflammation". Two hundred and five original articles matching these criteria were initially selected, although only those articles that included specific gene expression results (77) were later considered for this review and separated into three major topics: the regulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver. Particular strains of Bifidobacteria, Lactobacilli, Escherichia coli, Propionibacterium, Bacillus and Saccharomyces influence the gene expression of mucins, Toll-like receptors, caspases, nuclear factor-κB, and interleukins and lead mainly to an anti-inflammatory response in cultured enterocytes. In addition, the interaction of commensal bacteria and probiotics with the surface of antigen-presenting cells in vitro results in the downregulation of pro-inflammatory genes that are linked to inflammatory signaling pathways, whereas other anti-inflammatory genes are upregulated. The effects of probiotics have been extensively investigated in animal models ranging from fish to mice, rats and piglets. These bacteria induce a tolerogenic and hyporesponsive immune response in which many genes that are related to the immune system, in particular those genes expressing anti-inflammatory cytokines, are upregulated. By contrast, information related to gene expression in human intestinal cells mediated by the action of probiotics is scarce. There is a need for further clinical studies that evaluate the mechanism of action of probiotics both in healthy humans and in patients with chronic diseases. These types of clinical studies are necessary for addressing the influence of these microorga...

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“…However, no differences were found between AH1206-treated and control piglets when comparing body weight gain, feed efficiency (gain:intake), and histological and physiological modifications in intestines. Another recent study evaluated the effect of the co-administration of B. subtilis RJGP16 and Lactobacillus salivarius B1 on intestinal immunity in piglets (53). Authors demonstrated that probiotic administration increased the expression of IL-6, porcine beta-defensins, and IgA producing cells in the intestine, clearly showing that co-administration of RJGP16 and B1 strains strongly enhances the intestinal mucosal immunity of piglets.…”

Section: Intestinal Inflammation In Piglets After Weaning: Impact Of mentioning

confidence: 99%

Modulation of Intestinal TLR4-Inflammatory Signaling Pathways by Probiotic Microorganisms: Lessons Learned from Lactobacillus jensenii TL2937

2014

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The intestinal mucosa plays a critical role in the host’s interactions with innocuous commensal microbiota and invading pathogenic microorganisms. Intestinal epithelial cells (IECs) and gut associated immune cells recognize the bacterial components via pattern-recognition receptors (PRRs) and are responsible for maintaining tolerance to the large communities of resident luminal bacteria while being also able to mount inflammatory responses against pathogens. Toll-like receptors (TLRs) are a major class of PRRs that are present on IECs and immune cells which are involved in the induction of both tolerance and inflammation. A growing body of experimental and clinical evidence supports the therapeutic and preventive application of probiotics for several gastrointestinal inflammatory disorders in which TLRs exert a significant role. This review aims to summarize the current knowledge of the beneficial effects of probiotic microorganisms with the capacity to modulate the immune system (immunobiotics) in the regulation of intestinal inflammation in pigs, which are very important as both livestock and human model. Especially we discuss the role of TLRs, their signaling pathways, and their negative regulators in both the inflammatory intestinal injury and the beneficial effects of immunobiotics in general, and Lactobacillus jensenii TL2937 in particular. This review article emphasizes the cellular and molecular interactions of immunobiotics with IECs and immune cells through TLRs and their application for improving animal and human health.

show abstract

Co-administration of Bacillus subtilis RJGP16 and Lactobacillus salivarius B1 strongly enhances the intestinal mucosal immunity of piglets

Cited by 53 publications

References 40 publications

Effect of a multispecies lactobacillus formulation as a feeding supplement on the performance and immune function of piglets

Effect of a multispecies lactobacillus formulation as a feeding supplement on the performance and immune function of piglets

Modulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver by probiotics

Modulation of Intestinal TLR4-Inflammatory Signaling Pathways by Probiotic Microorganisms: Lessons Learned from Lactobacillus jensenii TL2937

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