Co-administration effects of α-lipoic acid and nucleo CMP on arousal and sensory cortical activity

Abstract

Objective: To evaluate the combined effects of lipoic acid and nuclear CMP on arousal and sensory cortical activity in normal healthy volunteers. Method: Eighty healthy volunteers enrolled in this study, the volunteers were divided into four groups'. Group A: take a placebo and regarded as controlling. Group B: take nucleo CMP capsule 5mg/day. Group C: take lipoic acid 400mg/day. Group D: take nucleo CMP and lipoic acid/ day. The duration of treatment was two weeks. CFFF tests measured via Leeds psychomotor battery tester. Student t-test, simple correlation and ANOVA test via SPSS version 18, taking p<0.05 as the lowest limit of significance. Results: lipoic acid improves fusion frequency (ascending) insignificantly and flicker (descending) frequency significantly in normal healthy volunteers. Nucleo CMP leads to a significant amelioration of critical flicker frequency, flicker percent and fusion percent p<0.05, but, it produced insignificant effects on a flicker index, critical fusion frequency and fusion index p>0.05. Combined lipoic acid and Nucleo CMP produced significant effects on critical flicker frequency, critical fusion frequency, flicker percent and fusion percent p<0.05, but they produced insignificant effects on a flicker index, fusion index, and CFFF p>0.05. Conclusion: lipoic acid and nucleo CMP produced significant arousal effects on normal healthy volunteers and improve cognitive functions.

Central Beneficial Effects of Trimetazidine on Psychomotor Performance in Normal Healthy Volunteers

“…Oxidative stress deteriorates the cognitive function and psychomotor performances, thus it was suggested that antioxidant effects of α-lipoid acid, Ginkgo biloba , and piracetam improve working memory and psychomotor performance,[ 17 18 ] and because of trimetazidine regarded as a novel antioxidant, it accelerates all measures of psychomotor performance in normal healthy volunteers. Recently, angiotensin receptor blockers improve psychomotor performance through antioxidant effect, augmentation of endogenous antioxidant enzymes, and significant reduction of lipid peroxidations.…”

The Potential Role of Thioctic Acid in the Attenuation of Doxorubicin Induced-Cardiotoxicity

“…Several studies showed that thioctic acid improves several conditions in the body that caused by free radicals, for example heart disease, cancer and other disorders which related with inflammation and aging [18]. The oxidized thioctic acid and reduced thioctic acid forms a potent redox couple that has a potent reduction potential so they consider as a potent antioxidants [19]. Truly, both thioctic acid and reduced thioctic acid scavenge different type of free radical such as hydroxyl radicals and hypochlorous acid, but the thioctic acid only cans scavenge singlet oxygen [20].…”

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“…Several studies showed that thioctic acid improves several conditions in the body that caused by free radicals, for example heart disease, cancer and other disorders which related with inflammation and aging [18]. The oxidized thioctic acid and reduced thioctic acid forms a potent redox couple that has a potent reduction potential so they consider as a potent antioxidants [19]. Truly, both thioctic acid and reduced thioctic acid scavenge different type of free radical such as hydroxyl radicals and hypochlorous acid, but the thioctic acid only cans scavenge singlet oxygen [20].…”