Co-activation of the amygdala, hippocampus and inferior frontal gyrus during autobiographical memory retrieval

Greenberg, Daniel; Rice, Heather J.; Cooper, Jane L.; Cabeza, Roberto; Rubin, David C.; LaBar, Kevin S.

doi:10.1016/j.neuropsychologia.2004.09.002

Cited by 238 publications

(179 citation statements)

References 99 publications

Supporting

Mentioning

150

Contrasting

Unclassified

Order By: Relevance

“…In patients with frontotemporal lobar degeneration, episodic autobiographical memory as assessed by the Autobiographical Interview was related to left inferior parietal parenchymal volume (along with bilateral temporal and left posterior cingulate/retrosplenial volumes; McKinnon et al, in press). Consistent with these patient reports, several functional neuroimaging studies of autobiographical recollection have revealed significant lateral parietal activity (e.g., Addis et al, 2004;Gilboa et al, 2004;Greenberg et al, 2005;Levine et al, 2004; for a review, see Svoboda et al, 2006), in addition to medial parietal, retrosplenial, and posterior cingulate activity. For example, Levine et al (2004) played back audiotapes of descriptions of real-life experiences to volunteers who had recorded them over several weeks.…”

Section: Resultssupporting

confidence: 62%

Does lateral parietal cortex support episodic memory?

et al. 2008

View full text Add to dashboard Cite

Although neuroimaging and human lesion studies agree that the medial parietal region plays a critical role in episodic memory, many neuroimaging studies have also implicated lateral parietal cortex, leading some researchers to suggest that the lateral region plays a heretofore underappreciated role in episodic memory. Because there are very few extant lesion data on this matter, we examined memory in six cases of focal lateral parietal damage, using both clinical and experimental measures, in which we distinguished between recollection and familiarity. The patients did not have amnesia, but they did show evidence of disrupted recollection on an anterograde memory task. Although the exact mechanisms remain to be elucidated, lateral parietal damage appears to impair some aspects of episodic memory.

show abstract

Section: Resultssupporting

confidence: 62%

Does lateral parietal cortex support episodic memory?

et al. 2008

View full text Add to dashboard Cite

show abstract

“…y-axes represent average signal change. From "Co-Activation of the Amygdala, Hippocampus and Inferior Frontal Gyrus During Autobiographical Memory Retrieval," by D. L. Greenberg et al, 2005, Neuropsychologia, 43, p. 665. Copyright 2005 by Elsevier.…”

Section: Resultsmentioning

confidence: 99%

“…In an attempt to address some of these issues, Greenberg et al (2005) used an event-related fMRI paradigm to examine emotional autobiographical memory. In this study, participants were presented with self-produced autobiographical memory cues derived from a prescanning session.…”

Section: Autobiographical Retrievalmentioning

confidence: 99%

Retrieval of emotional memories.

Buchanan

2007

Psychological Bulletin

373

238

View full text Add to dashboard Cite

Long-term memories are influenced by the emotion experienced during learning as well as by the emotion experienced during memory retrieval. The present article reviews the literature addressing the effects of emotion on retrieval, focusing on the cognitive and neurological mechanisms that have been revealed. The reviewed research suggests that the amygdala, in combination with the hippocampus and prefrontal cortex, plays an important role in the retrieval of memories for emotional events. The neural regions necessary for online emotional processing also influence emotional memory retrieval, perhaps through the reexperience of emotion during the retrieval process. Keywords emotion; memory; retrieval; amygdala; prefrontal cortex Retrieval of Emotional MemoriesMemories of our experiences are likely characterized by representations in the form of neuronal activity. Activity among a network of neurons represents a code for the experience of, say, a birthday party. When this network is activated by some cue that triggers a reexperience of that event, we are said to have recollected the birthday party. Emotional events are often remembered with greater accuracy and vividness (though these two characteristics do not always go together) than events lacking an emotional component (Reisberg & Hertel, 2005). This enhanced memory for emotional events has been attributed to interactions between the amygdala and other neural areas such as the hippocampus and prefrontal cortex (PFC) (Cahill & McGaugh, 1996). The amygdala is active during emotional situations, and this activity influences the encoding and consolidation of the memory trace for the emotional event (see LaBar & Cabeza, 2006;Phelps, 2004, for a review). These effects on the "front end" of memory (attention, encoding, the early stages of consolidation) have been well documented, but the influence of emotion and amygdala activity on memory retrieval has been more difficult to demonstrate. This difficulty is partly due to the fact that, by definition, an emotional event exerts its influence during the initial experience of the event. Understanding the influence of emotion on retrieval mechanisms could have utility in treating disorders of emotion and memory such as depression and posttraumatic stress disorder (PTSD; Davis & Whalen, 2001;Elzinga & Bremner, 2002), in which emotion may influence all phases of memory. Given that it is at the retrieval stage that the pathological effects of negative emotion are most often observed (Elzinga & Bremner, 2002;Williams & Scott, 1988), perhaps this is also where treatment may work most effectively. Recent work on the neurobiology of retrieval, extinction learning, and potential treatments for psychopathology highlight the broad influence that emotion exerts on memory retrieval mechanisms. In this review, I examine this influence and discuss the applications of this work across many areas of psychology.Correspondence concerning this article should be addressed to Tony W. Buchanan, who is now at the Department of Psychology...

show abstract

“…While the first route is thought to be mostly mediated by the hippocampus and prefrontal cortex, the amygdala is thought to be engaged in the emotional reactions to memories, but these systems are highly interlinked (e.g., Greenberg et al 2005). Therefore, it is also of interest to know whether these routes can be affected separately.…”

mentioning

confidence: 99%

Psychophysiological responding to emotional memories in healthy young men after cortisol and propranolol administration

et al. 2009

View full text Add to dashboard Cite

Rationale Propranolol is found to reduce physiological hyper-responsiveness in post traumatic stress disorder (PTSD), possibly by affecting reconsolidation after the reactivation of traumatic memories. Cortisol is found to attenuate declarative memory retrieval, but it is unknown whether it also reduces physiological responses to emotional memories. Objectives To examine whether the effects of propranolol on physiological responding to emotional memories can also be found in healthy controls and to investigate the immediate and prolonged effects of cortisol on physiological responding to emotional memories, we tested these effects in 79 healthy young men. Materials and methods After preparing a script of a negative disturbing memory, participants were instructed to imagine this event 1 week later after ingestion of either 35 mg cortisol, 80 mg propranolol, or a placebo. Physiological responding to the script-driven imagery was recorded. Another week later, after washout, the imagery was repeated again. During all three sessions as well as 8 months later, subjective emotional reactions to the memories were assessed. ResultsThe emotionality of the memories was reduced over time, which was not affected by the treatments, however. The personal emotional script did evoke higher skin conductance responses than a neutral story, which decreased 1 week later, but no effects were found of either propranolol or cortisol on this responsiveness. Conclusions Whereas healthy males do show psychophysiological responding to personal emotional scripts, the effects of cortisol and propranolol on physiological responses to emotional memories might be specific to clinical groups characterized by hyper-responsiveness, like PTSD. Future studies using longer-acting doses and more elaborate reactivation procedures in both healthy men and women could shed more light on the effects of cortisol and propranolol on psychophysiological responding to emotional memories.

show abstract

Co-activation of the amygdala, hippocampus and inferior frontal gyrus during autobiographical memory retrieval

Cited by 238 publications

References 99 publications

Does lateral parietal cortex support episodic memory?

Does lateral parietal cortex support episodic memory?

Retrieval of emotional memories.

Psychophysiological responding to emotional memories in healthy young men after cortisol and propranolol administration

Contact Info

Product

Resources

About