Co-activation of LIN28A and CTNNB1 disturbs cortical neuronal migration and pia mater integrity
Jelena Navolić,
Sara Hawass,
Manuela Moritz
et al.
Abstract:Developmental signalling pathways act in stage and tissue dependent relation and mis-activation can drive tumour formation. The RNA-binding protein LIN28A maintains stemness and is overexpressed in embryonal brain tumours. Activating mutations of CTNNB1 - the WNT pathway effector - have been reported in respective brain tumours. The aim of this study was to investigate the interplay of these oncogenic proteins during embryonal brain development. The combination of both oncogenic factors did not lead to brain t… Show more
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