CO 2 gas–liquid mass transfer and k L a estimation: Numerical investigation in the context of airlift photobioreactor scale-up

Ndiaye, Mbalo; Gadoin, Émilie; Gentric, Caroline

doi:10.1016/j.cherd.2018.03.001

Cited by 30 publications

(9 citation statements)

References 32 publications

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“…Mass transfer describes the CO 2 absorption inside the PBR, and the coefficient ( k L a ) is calculated according to the following formula: k normalL a = 12 α normalg d D L U slip 3 π d 0.25em where α g is the gas fraction, d is the diameter of the bubble, U slip is the slip velocity of gas and liquid, and D L is the molecular diffusion coefficient of O 2 .…”

Section: Methodsmentioning

confidence: 99%

“…Compared with time-consuming and high-cost experiments, numerical models have been widely used in the design, optimization, and performance evaluation of PBRs in recent years. For examples, the computational fluid dynamics (CFD) model was applied to describe the internal flow ,− and mixing conditions of the bioreactor; coupled with the CFD model, the particle model was used to simulate the movement of cells and evaluate the light utilization or mixing conditions; − the mass transfer model − was adopted to calculate the CO 2 absorption of algae in medium; and the light model was used to estimate the light utilization of algae in the reactor. , Table summarizes the above relevant CFD studies on flow and mixing, particle model, mass transfer model, and light model, which indicates that CFD simulation is the most basic job in the reactor design and optimization. However, most previous research studies only used relevant CFD modules to study part of the performance of PBRs and found the optimal cultivation conditions through experiments, , but there was a lack of comprehensive study on these conditions through a model system.…”

Section: Introductionmentioning

confidence: 99%

“…Mass Transfer Model. Mass transfer describes the CO 2 absorption inside the PBR,27 and the coefficient (k L a) is calculated according to the following formula:36 …”

mentioning

confidence: 99%

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Integrated Model for Design, Optimization, Scale-Up, Culture Scheme, and Production Evaluation of a Bioreactor and Its Application for Improving Algal Biomass and Carbon Fixation in Bioreactors

Zhao

Wang

et al. 2022

ACS Sustainable Chem. Eng.

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A comprehensive numerical model system for the bioreactor design, structure and cultivation condition optimization, scale-up, and carbon fixation performance evaluation was proposed. Three basic models of computational fluid dynamics, particle and mass transfer, and two improved models of algae growth and light accumulation were integrated innovatively. The algae growth model directly predicted the algal production performance of the bioreactor, and the error was less than 15% compared with the experimental results. The light accumulation model was proposed to simulate the spatial distribution of light utilization with the changes of algal concentration and light intensity. The model system was applied to scale up the flat plate photobioreactor with inclined baffles, and the results showed that the photobioreactor with 9 cm light path had a maximum ideal areal productivity (505.94 g/m 2 ) and better performance. Based on the light accumulation model, the strategy of changing the surface light intensity during the cultivation was proposed to maintain the light utilization and increase the production. Under the optimized surface light intensity, the maximum algal concentration and the average carbon fixation rate of the bioreactor were 43.41 and 248.35% higher than those of the constant light intensity. The proposed model system is a reliable and efficient experimental alternative tool for algal production evaluation and carbon fixation application of the bioreactor.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Integrated Model for Design, Optimization, Scale-Up, Culture Scheme, and Production Evaluation of a Bioreactor and Its Application for Improving Algal Biomass and Carbon Fixation in Bioreactors

Zhao

Wang

et al. 2022

ACS Sustainable Chem. Eng.

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“…The gas-liquid mass transfer coefficient (K L a) indicates the oxygen supply capacity in the bioreactor. The K L a of the bioreactor is calculated as follows (Ndiaye et al 2018):…”

Section: Calculation Of Hydrodynamic Characteristic Parametersmentioning

confidence: 99%

A novel scale-up strategy for cultivation of BHK-21 cells based on similar hydrodynamic environments in the bioreactors

Teng

2021

Bioresour. Bioprocess.

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The scale-up of animal cell cultivation is important but remains complex and challenging. In the present study, we propose a novel scale-up strategy for baby hamster Syrian kidney-21 (BHK-21) cell cultivation based on similar hydrodynamic environments. The hydrodynamic characteristics of the different scale bioreactors were determined by computational fluid dynamics (CFD) and further correlated with the agitation speed. The optimal hydrodynamic environment for cell cultivation and vaccine production was determined from the cultivation experiments of BHK-21 cells in 5-L laboratory-scale bioreactors equipped with different impellers at various agitation speeds. BHK-21 cell cultivation was scaled up from 5-L to 42-, 350-, and 1000-L bioreactors by adjusting the agitation speed to make the hydrodynamic features similar to those in the 5-L bioreactor, especially for the shear rate in the impeller zone (γimp) and energy dissipation rate in the tank bulk zone (εtan). The maximum cell density and cell aggregation rate in these scaled-up bioreactors were in the range of 4.6 × 106 ~ 4.8 × 106 cells/mL and 16 ~ 20%, which are comparable to or even better than those observed in the 5-L bioreactor (maximum cell density 4.8 × 106 cells/mL, cell aggregation rate 21%). The maximum virus titer of 108.0 LD50/mL achieved in the 1000-L bioreactor was close to 108.3 LD50/mL that obtained in the 5-L bioreactor. Hence, the scale-up strategy proposed in this study is feasible and can efficiently facilitate the scale-up processes of animal cell cultivation.

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“…Sabeti et al 15 investigated the effect of baffle on mixing performance and bioremoval efficiency of stirred tank PBR by Chlorella vulgaris with the use of CFD. In ALPBR, CFD studies were carried out for a wide range of applications such as characterization of the hydrodynamic variables affecting the multiphase flow (water–air–microalgae), 16 investigation of the flow patterns, mixing efficiency and gas holdup profile for Haematococcus pluvialis cultivation, 17 evaluation of CO 2 mass transfer capability and overall volumetric mass transfer coefficient for CO 2 , 18 development of a multiphysics model to predict the effects of fluid mixing and shear stress on Porphyridium sp. growth, 19 and examination of cultivation performance for different draft tube configurations 20 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of scale‐up methodologies and computational fluid dynamics simulation for fucoxanthin production in airlift photobioareactor

Guler

Deniz

Demirel

et al. 2020

Asia-Pacific J Chem Eng

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Researches about commercial-scale production of fucoxanthin are increasing day by day due to the much interest of its broad beneficial health effects. The aim of this study was to investigate the scale-up methodologies in airlift photobioreactor and to simulate fluid flow using computational fluid dynamics (CFD) for fucoxanthin production from Phaeodactylum tricornutum microalgae. During the transition process from 1-L cultivation bottle to the 2-L airlift photobioreactor, the constant mixing time, the constant volumetric oxygen transfer coefficient, and the constant volumetric power consumption rate were evaluated as scale-up methodologies under laboratory conditions. Maximum fucoxanthin yield was found as 1.01 ± 0.07 mg g −1 using scale-up strategy based on constant volumetric power consumption rate. After that, CFD simulation was performed in order to examine flow characteristics, mixing efficiency, hydrodynamics, and gas holdup for selected operation conditions. It was observed that mixing efficiency was low because the draft tube configuration prevented the circulation of fluid and caused a heterogenic culture medium inside the reactor. It is possible to overcome this bottleneck by developing the effective draft tube.

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CO 2 gas–liquid mass transfer and k L a estimation: Numerical investigation in the context of airlift photobioreactor scale-up

Cited by 30 publications

References 32 publications

Integrated Model for Design, Optimization, Scale-Up, Culture Scheme, and Production Evaluation of a Bioreactor and Its Application for Improving Algal Biomass and Carbon Fixation in Bioreactors

Integrated Model for Design, Optimization, Scale-Up, Culture Scheme, and Production Evaluation of a Bioreactor and Its Application for Improving Algal Biomass and Carbon Fixation in Bioreactors

A novel scale-up strategy for cultivation of BHK-21 cells based on similar hydrodynamic environments in the bioreactors

Evaluation of scale‐up methodologies and computational fluid dynamics simulation for fucoxanthin production in airlift photobioareactor

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