CNT Applications in Drug and Biomolecule Delivery

Chandrasekhar, Prasanna

doi:10.1007/978-3-319-69378-1_10

Cited by 13 publications

(4 citation statements)

References 1,600 publications

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“…Several compounds have been used to serve the medical industry including carbon-based materials (Chandrasekhar, 2018;Liu, Cui, & Losic, 2013), metallic nanoparticles (Adeyemi & Sulaiman, 2015), polymer-based materials (Hughes, 2017), and lipid-based materials (Xu et al, 2013). Studies have shown that carbon-based nanomaterials are prominent due to their ease of functionalization, and a comparative study suggested that ND has better biocompatibility than any other carbon nanoparticles (Ho, Wang, & Chow, 2015;.…”

Section: Applications In Biomedical Areasmentioning

confidence: 99%

Nanodiamond in composite: Biomedical application

Rehman

Houshyar

Wang

2020

J Biomedical Materials Res

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The biocompatibility of materials is the determining factor for them to be applied in biomedical areas. Nanodiamond (ND) has gained increasing interest in this area due to its biocompatibility, ease of surface functionalization and excellent mechanical performance. ND has been widely used to reinforce biopolymers, and the resultant biocomposites have found applications in bone tissue engineering, chemotherapeutic drug delivery, and wound healing. Fluorescent ND, when combined with biopolymers, is serving for bioimaging and sensing applications. Herein, we contribute a description of ND, recent trends in its adoption for biopolymers, functionalization methods, amalgamation techniques of ND with biopolymers, potential applications of these composites in the biomedical field and future perspectives.biocompatibility, biocomposites, biopolymers, nanodiamond, scaffold

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Section: Applications In Biomedical Areasmentioning

confidence: 99%

Nanodiamond in composite: Biomedical application

Rehman

Houshyar

Wang

2020

J Biomedical Materials Res

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“…Properties, including mechanical strength, fracture toughness, thermal stability, permittivity, and electrical conductivity, are known to be improved by introducing tiny quantities of CNTs [13]. Because of its distinctive mechanical, thermal, and electrical characteristics, epoxy is desirable for many applications, including fiber-reinforced composites, laminates, adhesives, and coatings [6,[14][15][16][17][18]. The qualities of composites with various kinds of fillers' microwave absorption are the subject of several investigations.…”

Section: Introductionmentioning

confidence: 99%

“…Such composites could be thin and light, with the exception of having a high absorption intensity and a broad absorption bandwidth [14]. Additionally, hexaferrites have benefits such cheap cost, simple production, strong coercivity, high Curie temperature, and high magnetic loss [15][16][17][18], therefore the incidence of electromagnetic radiation may be taken into account in hexaferrite based composites. However, after the epoxy has dried, it becomes hard, brittle, and has a low impact strength [4,5,19,20].…”

Section: Introductionmentioning

confidence: 99%

Development and Comparative Analysis of MWCNT-Polymer Composites for Bioelectronics Application

Jain

Abdul-Zahra³

2023

MSF

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The development of biosensors is essential while determining the inside body assaying and assessing implants in-vivo applications. Researchers are doing remarkable studies in certain areas, but output for receiving, adaptability and circulation of nutrients are also essential. For examining the similar functionality, multi-walled carbon nanotube epoxy-composite with varying filler percentages is examined and compared using electromechanical and morphological assessment. Mechanical investigations like tensile and flexural tests were performed in addition to the hardness of specimens. The DC conductivity test is performed to determine the charge conductivity along with NMR for measuring the signal responses. The surface characterization is performed to determine the morphological properties of specimens. It is observed that the mechanical properties increased and decreased after exceeding the filler composition to addition to 2% of total weight. In comparison, the conductivity and magnetic resonance enhance to a further extent showing proportional to addition of nanofillers, thus making them potential applications for flexible organic bioelectronics products.

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“… 8 , 9 CNTs are also key nanocarriers for the delivery of drugs and therapeutic molecules. 10 However, to meet a specific and targeted mission, CNTs have to be functionalized with appropriate moieties to become highly efficient for targeting, imaging, and therapeutic purposes. 11 , 12 …”

Section: Introductionmentioning

confidence: 99%

Dynamics of Antimicrobial Peptide Encapsulation in Carbon Nanotubes: The Role of Hydroxylation

Dehaghani¹,

Yousefi²,

Seidi³

et al. 2022

IJN

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Introduction: Carbon nanotubes (CNTs) have been widely employed as biomolecule carriers, but there is a need for further functionalization to broaden their therapeutic application in aqueous environments. A few reports have unraveled biomolecule-CNT interactions as a measure of response of the nanocarrier to drug-encapsulation dynamics. Methods: Herein, the dynamics of encapsulation of the antimicrobial peptide HA-FD-13 (accession code 2L24) into CNTs and hydroxylated CNTs (HCNTs) is discussed. Results: The van der Waals (vdW) interaction energy of CNT-peptide and HCNT-peptide complexes decreased, reaching −110.6 and −176.8 kcal.Mol −1 , respectively, once encapsulation of the peptide inside the CNTs had been completed within 15 ns. The free energy of the two systems decreased to −43.91 and −69.2 kcal.Mol −1 in the same order. Discussion: The peptide was encased in the HCNTs comparatively more rapidly, due to the presence of both electrostatic and vdW interactions between the peptide and HCNTs. However, the peptide remained encapsulated throughout the vdW interaction in both systems. The negative values of the free energy of the two systems showed that the encapsulation process had occurred spontaneously. Of note, the lower free energy in the HCNT system suggested more stable peptide encapsulation.

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CNT Applications in Drug and Biomolecule Delivery

Cited by 13 publications

References 1,600 publications

Nanodiamond in composite: Biomedical application

Nanodiamond in composite: Biomedical application

Development and Comparative Analysis of MWCNT-Polymer Composites for Bioelectronics Application

Dynamics of Antimicrobial Peptide Encapsulation in Carbon Nanotubes: The Role of Hydroxylation

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