CNS pharmacological effects of the hydroalcoholic extract of Sida cordifolia L. leaves

Franco, Carlúcia Ithamar Fernandes; Morais, Liana Clébia Soares Lima de; Quintans‐Júnior, Lucindo José; Almeida, Reinaldo Nóbrega de; Antoniolli, Ângelo Roberto

doi:10.1016/j.jep.2005.01.008

Cited by 46 publications

(22 citation statements)

References 18 publications

(16 reference statements)

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“…This is an essential issue as there is evidence from rodent models suggesting that the administration of plant extracts may result in a range of either positive (Herrera-Ruiz et al, 2006;Pultrini et al, 2006) or negative effects (Franco et al, 2005) on the behaviour of parasitised hosts. Changes in the behaviour of hosts, for example the introduction of behaviour that may be considered stereotypic as an outcome of the plant administration, may result in significant costs on the host's welfare status.…”

Section: Medicinal Plants and Parasitised Hosts: Viewing The Whole Pimentioning

confidence: 99%

Medicinal plants for helminth parasite control: facts and fiction

Athanasiadou

Githiori

Kyriazakis

2007

Animal

198

129

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The use of medicinal plants for the prevention and treatment of gastro-intestinal parasitism has its origin in ethnoveterinary medicine. Although until recently the majority of the evidence on the antiparasitic activity of medicinal plants was anecdotal and lacked scientific validity, there is currently an increasing number of controlled experimental studies that aim to verify and quantify such plant activity. There are indeed a large number of plants whose anthelmintic activity has been demonstrated under controlled experimentation, either through feeding the whole plant or administering plant extracts to parasitised hosts. However, contrary to traditional expectation, there are also a great number of plants with purported antiparasitic properties, which have not been reproduced under experimental conditions. In this paper, we discuss the source of such inconsistencies between ethnoveterinary wisdom and scientific experimentation. We focus on the strengths and weaknesses of the existing methodologies used in the controlled studies to determine the activity of antiparasitic plants. We discuss issues like the seasonal and environmental variability of the plant composition, and how this can affect their antiparasitic properties and highlight the importance of identifying the mechanisms of action of such plants and the target parasite species. In addition to their antiparasitic properties, medicinal plants may also have anti-nutritional properties, which can affect animal performance and behaviour. For this reason, we emphasise the need for considering additional dimensions when evaluating medicinal plants. We also question whether using similar criteria as those used for the evaluation of anthelmintics is the way forward. We propose that a holistic approach is required to evaluate the potential of medicinal plants in parasite control and maximise their benefits on parasitised hosts. Keywords: bioactive plants, ethnoveterinary medicine, medicinal plants, parasites, ruminants IntroductionFor centuries, medicinal plants have been used to combat parasitism, and in many parts of the world are still used for this purpose. In ethnoveterinary medicine, which draws inspiration from traditional practice, there seems to be a range of plant/s or plant extract suitable for treating almost every parasitic disease of livestock (International Institute of Rural Reconstruction (IIRR), 1994). For example, seeds of garlic, onion and mint have been used to treat animals that suffer from gastro-intestinal parasitism, whereas extracts of the tobacco plant have been used to treat the skin of livestock afflicted with external parasites (Guarrera, 1999). Leaves, dried flowers and oil from Chenopodium ambrosioides, a shrub that originated from Central America and has been distributed around the world, have all been used as anthelmintics since the early 1900s (Guarrera, 1999).Reports from around the world include exhaustive lists of plants that have been reported to have medicinal properties (Hammond et al., 1997;Akhtar et al., 2000;Waller ...

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Section: Medicinal Plants and Parasitised Hosts: Viewing The Whole Pimentioning

confidence: 99%

Medicinal plants for helminth parasite control: facts and fiction

Athanasiadou

Githiori

Kyriazakis

2007

Animal

198

129

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“…LD 50 value was found to be 2639 mg/kg b.w. However, oral administration of the extract was found to be safe [23]. Asdaq et al also reported that methanolic extract of this plant was safe up to 5 g/kg dose [24].…”

Section: Discussionmentioning

confidence: 99%

Ameliorative Effect of Sida Cordifolia L. Against Scopolamine-Induced Cognitive Deficit Mice Model

Khurana

Sharma

Patil

et al. 2017

Asian J Pharm Clin Res

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Objective: In this study, ameliorative effect of aqueous extracts of Sida cordifolia and hydroethanolic extracts of S. cordifolia L. (AESC and EESC, respectively) was evaluated against scopolamine (Sco)-induced amnesia in mice. S. cordifolia L. is a well-know Ayurvedic plant which has been administered anciently for various nervous disorders including loss of memory. Female Swiss albino mice were used for Sco-induced amnesia model and acute toxicity study.Methods: Acute toxicity study was carried out to select safe and effective doses (50, 100 and 250 mg/kg; p.o.) of AESC and EESC for further pharmacological evaluation. The AESC and EESC at selected doses and donepezil (Dpl) (5 mg/kg; p.o.) were administered to different groups for consecutive 15 days. On 15 th day of treatment, Sco (0.4 mg/kg, intraperitoneally) was administered to different groups for induction of amnesia. Mice were subjected to transfer latency (TL) and step down latency (SDL) tests on the 16 th day to evaluate the effect of AESC and EESC on memory.Results: Sco treatment caused a significant increase in TL and decrease in SDL. The EESC significantly and dose dependently reversed the Sco-induced amnesia. The maximum effect was seen in EESC (100 mg/kg) treated group. This effect of EESC was comparable to the group treated with Dpl. The group treated with varying doses of AESC showed no significant effect on TL and SDL. Conclusion:These findings suggested the possible therapeutic potential of EESC (70%) for diseases related to memory dysfunctions like dementia in Alzheimer's disease.

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“…The roots and stems contain ephedrine, pseudoephedrine, hypaphorine, vasicinone, vasicinol, choline, and betaine constitute the major alkaloids. S. cordifolia is used in ayurvedic medicine for the treatment of inflammation of the oral mucosa, blenorrhea, asthmatic bronchitis, stomatitis, and nasal congestion [45].…”

Section: Description Of Begomovirus Infecting Mapsmentioning

confidence: 99%

Emerging threats of begomoviruses to the cultivation of medicinal and aromatic crops and their management strategies

Saeed

Samad

2017

VirusDis.

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Begomoviruses (family Geminiviridae) are responsible for extreme yield reduction in a number of economically important crops including medicinal and aromatic plants (MAPs). Emergence of new variants of viruses due to recombination and mutations in the genomes, modern cropping systems, introduction of susceptible plant varieties, global trade in agricultural products, and changes in climatic conditions are responsible for aggravating the begomovirus problems during the last two decades. This review summaries the current research work on begomoviruses affecting MAPs and provides various traditional and advanced strategies for the management of begomoviruses and vector in MAPs.

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CNS pharmacological effects of the hydroalcoholic extract of Sida cordifolia L. leaves

Cited by 46 publications

References 18 publications

Medicinal plants for helminth parasite control: facts and fiction

Medicinal plants for helminth parasite control: facts and fiction

Ameliorative Effect of Sida Cordifolia L. Against Scopolamine-Induced Cognitive Deficit Mice Model

Emerging threats of begomoviruses to the cultivation of medicinal and aromatic crops and their management strategies

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