Implications of the Blood-Brain Barrier and Its Manipulation 1989
DOI: 10.1007/978-1-4615-7255-8_13
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CNS Lupus and the Blood-Brain Barrier

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Cited by 14 publications
(9 citation statements)
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“…This signaling subunit is utilized by several cytokines including IL-6, IL-11, OSM, LIF, and CNTF (17). Interestingly, IL-6, IL-11, and LIF have effects on megakaryocytopoiesis (31)(32)(33). Perhaps the ability to activate STAT1 and STAT3 underlies the effects common to TPO and these other cytokines.…”
Section: Resultsmentioning
confidence: 99%
“…This signaling subunit is utilized by several cytokines including IL-6, IL-11, OSM, LIF, and CNTF (17). Interestingly, IL-6, IL-11, and LIF have effects on megakaryocytopoiesis (31)(32)(33). Perhaps the ability to activate STAT1 and STAT3 underlies the effects common to TPO and these other cytokines.…”
Section: Resultsmentioning
confidence: 99%
“…The minimal representation of megakaryocytes in the bone marrow, estimated at Ͻ0.5% of the bone marrow cells (1), has hindered the procurement of purified primary cell populations. Human cell lines with megakaryocyte-related characteristics or markers have many shortcomings, including outgrowth from leukemic bone marrow, expression of multiple nonmegakaryocyte lineage markers, and abnormal karyotypes (2). Murine megakaryocyte cell lines are essentially nonexistent.…”
mentioning
confidence: 99%
“…These anuclear cytoplasmic fragments are derived from bone marrow megakaryocytes and are highly differentiated (1). One of the specialized features found on the platelet membrane is the ␣ IIb /␤ 3 (also known as glycoprotein IIb/IIIa or CD41b) integrin receptor (2).…”
mentioning
confidence: 99%