CNS Involvement in Chronic Inflammatory Demyelinating Polyneuropathy: A Visual Evoked Potential Study

“Chronic” optic neuropathy in chronic inflammatory demyelinating polyneuropathy: A case report

“…Previous reports about CIDP accompanied by clinically chronic optic neuropathy are rare, although subclinical VEP abnormalities in CIDP might be common . Holtkamp, et al .…”

“…Chronic inflammatory demyelinating polyneuropathy (CIDP) is known as an autoimmune disorder of the peripheral nervous system, and the clinical course is chronic progressive or relapsing. Several reports have suggested central nervous system (CNS) involvement in CIDP, and some cases also report optic neuropathy . We had a patient with CIDP accompanied by “chronic” optic neuropathy.…”

Características do envolvimento do Sistema Nervoso Central na Polirradiculoneuropatia Inflamatória Desmielinizante Crônica: um estudo mediante técnicas quantitativas de Imagem por Ressonância Magnética

“…Whether this combined demyelinating syndrome lies on a spectrum between MS and CIDP or is a separate pathogenic entity will require further investigation. (Barišić et al, 2006;Feasby et al, 1990;Mendell et al, 1987;Ohtake et al, 1990;Ormerod et al, 1990;Pineda et al, 2007;Takeda et al, 2010;Uncini et al, 1991;Waddy et al, 1989) In the last 25 years, several studies have reported the involvement of the CNS in the CIDP. Ohtake et al, 1990;Ormerod et al, 1990;Pineda et al, 2007;Takeda et al, 2010;Uncini et al, 1991) The reports have used different populations -Asians (Ohtake et al, 1990;Pineda et al, 2007), north-Americans Takeda et al, 2010) and Europeans people (Barišić et al, 2006;Ormerod et al, 1990;Uncini et al, 1991;Waddy et al, 1989) -and evaluation techniques -Clinical (Barišić et al, 2006;Ormerod et al, 1990;Pineda et al, 2007;Waddy et al, 1989),…”

“…Electrophysiological (Barišić et al, 2006;Komori et al, 1990;Ohtake et al, 1990;Ormerod et al, 1990;Takeda et al, 2010;Waddy et al, 1989), MRI (Barišić et al, 2006;Ohtake et al, 1990;Ormerod et al, 1990;Uncini et al, 1991;Waddy et al, 1989) and Evoked potentials (Barišić et al, 2006;Ohtake et al, 1990;Ormerod et al, 1990;Pineda et al, 2007;Waddy et al, 1989). In these reports not been used Brazilian or South American population evaluated with quantitative MRI (qMRI) techniques.…”

“…(Ormerod et al, 1990) A common finding in these reports is the subclinical CNS involvement in CIDP patients though the subclinical CNS abnormalities found in the Japanese patients were considered to be less frequent than in cases from Western countries. (Barišić et al, 2006;Feasby et al, 1990;Mendell et al, 1987;Ohtake et al, 1990;Ormerod et al, 1990;Pineda et al, 2007;Takeda et al, 2010;Uncini et al, 1991;Waddy et al, 1989) A more recent study suggests the existence of combined central and peripheral demyelinating lesions in CIDP and emphasize the possibility of a common pathogenic mechanism for both lesions. (Takeda et al, 2010) The MRI have been considered an important tool in all these previous reports, but it have been used as a qualitative tools.…”