CNS Depressant and Analgesic Activity of a Fraction Isolated from an Ethanol Extract of<i>Curcuma amada</i>Rhizomes

Mujumdar, A. M.; Naik, D. G.; Misar, Ashwini; Puntambekar, Hemalata M.; Dandge, Chitra

doi:10.3109/13880200490893429

Cited by 26 publications

(15 citation statements)

References 6 publications

(6 reference statements)

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“…Acetic acid induced writhing test was used for detecting peripheral analgesia, whereas hot plate and tail flick tests are most sensitive to centrally acting analgesics. 23 Studies done by Mujumdar et al, 24 Policegoudra RS et al 9 also suggest that CA has analgesic activity thus supporting our study.…”

Section: Hot Plate Methodsupporting

confidence: 84%

An Experimental Comparative Study of Analgesic Activity of Curcuma: Amada (Mango - Ginger) With Conventional Nsaid Aspirin in Male Albino Wistar Rats

Shanmukananda¹,

C²

2015

jebmh

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BACKGROUND: Mango ginger (Curcuma amada Roxb.) belongs to Zingiberaceae family has biological activities include antioxidant, antibacterial, antifungal, anti-inflammatory, antiallergic, CNS depressant and analgesic activity. The major chemical components include starch, phenolic acids, volatile oils, curcuminoids and terpenoids like difurocumenonol, amadannulen and amadaldehyde. Pain is often the first indication of disease or injury and a major symptom in many clinical conditions and can significantly interferes with a person's quality of life and general functioning. The standard and test drugs suppress the inflammatory mediators associated with pain. This article brings out the analgesic activity of C. Amada in comparison with aspirin. Therefore aqueous extract of C. amada was evaluated for analgesic activity in animal models of pain. OBJECTIVES: 1. To evaluate rhizomes of Curcuma Amada for analgesic activity in male albino wistar rats and to compare the analgesic activity with aspirin. 2. To Evaluate if combination of Curcuma Amada with aspirin is synergistic. MATERIALS AND METHODS: Albino rats are the proven models for analgesic studies. They were obtained from the animal house of DR.B. R. Ambedkar Medical College. Animals were maintained as per CPCSEA guidelines .The aqueous extract of Curcuma Amada was used. Aspirin (100mg/kg) was used as the standard analgesic drug. 4x4 groups of 6 Rats were used to ensure that results obtained were statistically significant using ANOVA test. Analgesic activity will be assessed with the help of following screening methods Acetic Acid Writhing Method using Acetic Acid, Tail Flick Method using the Analgesiometer, Tail Immersion Method using Hot Water (55 0 C) , Hot Plate method using Hot Plate. RESULTS: Aqueous extract of Curcuma Amada significantly suppressed the 1% acetic acid induced writhing response in rats when compared to standard drug aspirin. In the Tail flick and Hot plate test Curcuma Amada increases the latency period of pain (Reaction time). In the Tail immersion test the test drug significantly (P <0.001) reduced pain at 30 min when compared to the standard drug Aspirin at 60 min of oral administration. INTERPRETATION AND CONCLUSION: We can conclude that, Curcuma Amada possess analgesic activity which can be explained by animal models of pain. Probably, it acts by peripheral and central mechanisms. The combination of Curcuma Amada and Aspirin is synergistic.

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Section: Hot Plate Methodsupporting

confidence: 84%

An Experimental Comparative Study of Analgesic Activity of Curcuma: Amada (Mango - Ginger) With Conventional Nsaid Aspirin in Male Albino Wistar Rats

Shanmukananda¹,

C²

2015

jebmh

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“…The ethyl alcohol extract of mango ginger rhizome has antiinflammatory activity in acute and chronic administration in albino rats (Mujumdar et al 2000). Mujumdar et al also reported the presence of chemical compounds with hydroxyl, ester, carbonyl and olefin functional groups in ethyl alcohol extract.…”

Section: Anti-inflammatory Activitymentioning

confidence: 98%

Mango ginger (Curcuma amada Roxb.) – A promising spice for phytochemicals and biological activities

2011

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Mango ginger (Curcuma amada Roxb.) is a unique spice having morphological resemblance with ginger but imparts a raw mango flavour. The main use of mango ginger rhizome is in the manufacture of pickles and culinary preparations. Ayurveda and Unani medicinal systems have given much importance to mango ginger as an appetizer, alexteric, antipyretic, aphrodisiac, diuretic, emollient, expectorant and laxative and to cure biliousness, itching, skin diseases, bronchitis, asthma, hiccough and inflammation due to injuries. The biological activities of mango ginger include antioxidant activity, antibacterial activity, antifungal activity, anti-inflammatory activity, platelet aggregation inhibitory activity, cytotoxicity, antiallergic activity, hypotriglyceridemic activity, brine-shrimp lethal activity, enterokinase inhibitory activity, CNS depressant and analgesic activity. The major chemical components include starch, phenolic acids, volatile oils, curcuminoids and terpenoids like difurocumenonol, amadannulen and amadaldehyde. This article brings to light the major active components present in C. amada along with their biological activities that may be important from the pharmacological point of view.

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“…This showed the bioactivity of plant. Krishnaraju et al (2006) CNS depressant and analgesic activity Observation of reduction in barbiturate sleeping time, point out CNS depressant activity Mujumdar et al (2004) Bhat et al (1981) Antipyretic activity…”

Section: Biological Activities Description Reference Brine Shrimp Letmentioning

confidence: 99%

Phytochemical and pharmacological properties of Curcuma amada: A Review

Mahadevi

Kavitha

2020

ijrps

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Plants are considered as one of the main sources of biologically active materials. The medicinal property of a plant depends upon the physiologically active biochemical compounds called secondary metabolites. Curcuma amada is one of the important species of Curcuma family having medicinal and biological properties. The aim of the present paper assesses the phytochemicals, volatile compounds, antimicrobial and other biological activities, along with recent trends in research of C. amada. Volatile oils extracted from rhizomes of C. amada are rich in phytoconstituents. The major constituents found in its rhizomes are curcuminoids (curcumin, demethoxycurcumin, bisdemethoxycurcumin), penolic compounds (caffeic acid, gentisic acid, ferulic acid, gallic acid cinnamic acid), terpinoids (difurocumenol, amadannulen, amadaldehyde) and essential oil (β-myrcene and α-asarone). The curcuminoids present in C. amada is responsible for its therapeutic activities. It is traditionally used to treat various diseases which includes anti-inflammatory, anti-bacterial, anti-cancer, anti-tubercular, anti -allergy, anthelmintic and antipyretic activities. It also possesses healing of various skin diseases.

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CNS Depressant and Analgesic Activity of a Fraction Isolated from an Ethanol Extract ofCurcuma amadaRhizomes

Cited by 26 publications

References 6 publications

An Experimental Comparative Study of Analgesic Activity of Curcuma: Amada (Mango - Ginger) With Conventional Nsaid Aspirin in Male Albino Wistar Rats

An Experimental Comparative Study of Analgesic Activity of Curcuma: Amada (Mango - Ginger) With Conventional Nsaid Aspirin in Male Albino Wistar Rats

Mango ginger (Curcuma amada Roxb.) – A promising spice for phytochemicals and biological activities

Phytochemical and pharmacological properties of Curcuma amada: A Review

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