CNS activity of Alstonia macrophylla leaf extracts: an ethnomedicine of Onge of Bay Islands

Chattopadhyay, Debprasad; Arunachalam, G.; Ghosh, L. K.; Mandal, Asit Baran

doi:10.1016/j.fitote.2004.08.002

Cited by 30 publications

(23 citation statements)

References 18 publications

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“…On the other hand, the brewer's yeast induced hyperpyrexia method is a useful method to evaluate the antipyretic potential of test substances involving a subcutaneous injection of brewer's yeast in the test animals to produce fever (Chattopadhyay et al 2005). The infected or damaged tissue initiates the enhanced formation of pro-inflammatory mediators (e.g.…”

Section: Discussionmentioning

confidence: 99%

Anti-nociceptive and antipyretic activities of Solanum violaceum ortega

Karim

Islam

Tareq

et al. 2017

IJM

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Solanum violaceum Ortega has been used by the traditional medicine practitioners in pain and fever. This study aimed at investigating anti-nociceptive and antipyretic activities of methanol extract of leaf (MELSV), fruit (MEFSV) and root (MERSV) of S. violaceum in Swiss albino mice. Anti-nociceptive activity was evaluated using hot plate method while antipyretic by brewer's yeast induced hyperpyrexia. In both tests, test animals were divided into eight groups of six in each. The groups were treated as negative control (distilled water), standard and tests (250 and 500 mg/kg of MELSV/ MERSV/ MERSV). Diclofenac sodium (150 mg/kg) and paracetamol (150 mg/kg) were taken as standards for anti-nociceptive and antipyretic tests, respectively. All the treatments were administrated via oral gavages (p.o.). Results suggest that, the plant extracts dose-dependently increased retention time compared to the control groups. MELSV at 500 mg/kg significantly increased retention time on the hot-pate of the test animals than the MEFSV and MERSV treated groups. In the antipyretic test, both 250 and 500 mg/kg of MELSV and 500 mg/kg of MEFSV significantly (p <0.05) decreased temperature to the experimental animals 30, 60, 120 minutes. In conclusion, the crude extracts of S. violaceum exhibited anti-nociceptive and antipyretic activities. S. violaceum may be one of the good sources of anti-nociceptive and antipyretic compounds.

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Section: Discussionmentioning

confidence: 99%

Anti-nociceptive and antipyretic activities of Solanum violaceum ortega

Karim

Islam

Tareq

et al. 2017

IJM

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“…A part of the residue was stored in a dessicator for further study (Chattopadhyay et al, 2001(Chattopadhyay et al, , 2003(Chattopadhyay et al, , 2006. The phytochemical analysis (Trease and Evans, 1983;Arunachalam et al, 2002;Chattopadhyay et al, 2004) indicated the presence of tannins, flavonoids, triterpenoids, sterols, alkaloids and reducing sugars. The powdered residue (32 g) was then suspended in water and extracted with nbutanol.…”

Section: Extraction and Fractionationmentioning

confidence: 99%

“…Out of the three, fraction A was positive to terpenoid, fraction B to phytosterol and the CHCl 3 -MeOH fraction (fraction C) was positive for alkaloid in TLC. All the fractions were isolated separately, filtered, dried, and then subjected to CC by Aluminum oxide eluted with PE, PE: CHCl 3 (at different ratio), CHCl 3 , CHCl 3 : MeOH (at different ratio) and monitored by TLC (Chattopadhyay et al, , 2004. The fractions A and B were combined, condensed and recrystallized with suitable solvent system.…”

Section: Extraction and Fractionationmentioning

confidence: 99%

Evaluation of analgesic and antiinflammatory activity of Ophiorrhiza nicobarica, an ethnomedicine from Nicobar Islands, India

Chattopadhyay¹,

Das²,

Mandal³

et al. 2007

Oriental Pharmacy and Experimental Medicine

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SUMMARYThis study reports the analgesic, anti-inflammatory and membrane-stabilizing property of alcoholic extract of Ophiorrhiza nicobarica (ON), a wild herb, used as an anti-infective ethnomedicine of Nicobarese and Shompen tribes of Great Nicobar Island, India. We for the first time investigated the analgesic and antiinflammatory potential of this herb in acute, subacute and chronic model of inflammation in Swiss albino mice and Wistar albino rats, along with sheep RBC-induced sensitivity and membrane stabilization. The acetic acid induced writhing, tail flick and tail immersion tests are used as a model for evaluating analgesic activity; while the carrageenin-induced paw oedema was used as the model for acute inflammation, dextran-induced oedema as sub-acute and cotton-pellateinduced granuloma as chronic inflammatory model. The probable mode by which ON mediate its effect on inflammatory conditions was studied on sheep RBC-induced sensitivity and membrane stabilization. The in vitro results revealed that the ON extract possesses significant (P < 0.05) dose dependent analgesic and antiinflammatory activity at 200 and 300 mg/kg and its fractions at 50 mg/ kg, p.o. respectively, compared to the control groups. However, the extract failed to exhibit membrane-stabilizing property as it unable to reduce the level of haemolysis of RBC exposed to hypotonic solution. The acute toxicity studies of ON extract in rats and mice revealed that the extract was nontoxic even up to 3.0 g/kg body weight of the animals, with a high safety profile. We have isolated ursolic acid, β-sitosterol and harmaline respectively, from the bioactive part of the extract. The results indicated that the O. nicobarica is indeed beneficial in primary health care, and suggest that its anti-inflammatory activity may not be related to membrane-stabilization.

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“…The secondary impact of infection is tissue damage, inflammation, graft rejection, malignancy or other diseased states which results in fever or pyrexia (Chattopadhyay et al, 2005). The body's natural defense system generates in an environment for non survival of the infectious agent or damaged tissues.…”

Section: Introductionmentioning

confidence: 99%