Cnr1−/− has minimal impact on chlorpyrifos-mediated effects in the mouse endocannabinoid system, but it does alter lipopolysaccharide-induced cytokine levels in splenocytes

Szafran, Brittany N; Nichols, James M.; Nicaise, Ashleigh; Borazjani, Ali; Carr, Russell L.; Wilson, Juliet R; Ross, Matthew K.; Kaplan, Barbara L. F.

doi:10.1016/j.cbi.2023.110425

Cited by 2 publications

(1 citation statement)

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“…In splenic T cells and splenocytes from mice that were immune-activated by Legionella pneumophila , activation of CB1Rs suppressed IL-12Rβ2 (neuroprotective receptor) expression [ 61 ]. Also, CB1Rs are involved in neutrophil activation, and CB1R blockage suppresses their entry to injured areas and attenuates peripheral inflammation [ 55 , 62 , 63 ]. In mast cells, CB1R activation leads to sustained elevation in cAMP levels and reduction in mast cell activation [ 56 ].…”

Section: Cannabinoid Receptors and Immunomodulationmentioning

confidence: 99%

Cannabinoids’ Role in Modulating Central and Peripheral Immunity in Neurodegenerative Diseases

Sharon,

Yarmolinsky,

Khalfin

et al. 2024

IJMS

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Cannabinoids (the endocannabinoids, the synthetic cannabinoids, and the phytocannabinoids) are well known for their various pharmacological properties, including neuroprotective and anti-inflammatory features, which are fundamentally important for the treatment of neurodegenerative diseases. The aging of the global population is causing an increase in these diseases that require the development of effective drugs to be even more urgent. Taking into account the unavailability of effective drugs for neurodegenerative diseases, it seems appropriate to consider the role of cannabinoids in the treatment of these diseases. To our knowledge, few reviews are devoted to cannabinoids’ impact on modulating central and peripheral immunity in neurodegenerative diseases. The objective of this review is to provide the best possible information about the cannabinoid receptors and immuno-modulation features, peripheral immune modulation by cannabinoids, cannabinoid-based therapies for the treatment of neurological disorders, and the future development prospects of making cannabinoids versatile tools in the pursuit of effective drugs.

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