CNGCs: prime targets of plant cyclic nucleotide signalling?

Talke, Ina N.; Blaudez, Damien; Maathuis, Frans J. M.; Sanders, Dale

doi:10.1016/s1360-1385(03)00099-2

Cited by 219 publications

(196 citation statements)

References 66 publications

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“…CNGC proteins possess six transmembrane helices with a P loop between helices 5 and 6 that is responsible for ion selectivity and ion passage. The C terminus is characterized by a CaM binding domain that partially overlaps with a cyclic nucleotide binding domain (Talke et al, 2003). A recent study revealed an additional CaM binding site characterized by an IQ motif that lies C-terminal of the previously described CaM binding domain and that does not overlap with the cyclic nucleotide binding site (Fischer et al, 2013).…”

Section: Introductionmentioning

confidence: 98%

“…Among the few known targets of cGMP regulation in plant cells are cyclic nucleotide-gated channels (CNGCs; Talke et al, 2003). The Arabidopsis genome encodes 20 members of the CNGC family, which fall into five subgroups in the monocot rice (Oryza sativa) as well as in the dicot species Arabidopsis (Talke et al, 2003;Ma et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…The Arabidopsis genome encodes 20 members of the CNGC family, which fall into five subgroups in the monocot rice (Oryza sativa) as well as in the dicot species Arabidopsis (Talke et al, 2003;Ma et al, 2009). CNGC proteins possess six transmembrane helices with a P loop between helices 5 and 6 that is responsible for ion selectivity and ion passage.…”

Section: Introductionmentioning

confidence: 99%

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Phytosulfokine Regulates Growth in Arabidopsis through a Response Module at the Plasma Membrane That Includes CYCLIC NUCLEOTIDE-GATED CHANNEL17, H⁺-ATPase, and BAK1

et al. 2015

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Phytosulfokine (PSK) is perceived by the leucine-rich repeat receptor kinase PSKR1 and promotes growth in Arabidopsis thaliana. PSKR1 is coexpressed with the CYCLIC NUCLEOTIDE-GATED CHANNEL gene CNGC17. PSK promotes protoplast expansion in the wild type but not in cngc17. Protoplast expansion is likewise promoted by cGMP in a CNGC17-dependent manner. Furthermore, PSKR1-deficient protoplasts do not expand in response to PSK but are still responsive to cGMP, suggesting that cGMP acts downstream of PSKR1. Mutating the guanylate cyclase center of PSKR1 impairs seedling growth, supporting a role for PSKR1 signaling via cGMP in planta. While PSKR1 does not interact directly with CNGC17, it interacts with the plasma membrane-localized H + -ATPases AHA1 and AHA2 and with the BRI-associated receptor kinase 1 (BAK1). CNGC17 likewise interacts with AHA1, AHA2, and BAK1, suggesting that PSKR1, BAK1, CNGC17, and AHA assemble in a functional complex. Roots of deetiolated bak1-3 and bak1-4 seedlings were unresponsive to PSK, and bak1-3 and bak1-4 protoplasts expanded less in response to PSK but were fully responsive to cGMP, indicating that BAK1 acts in the PSK signal pathway upstream of cGMP. We hypothesize that CNGC17 and AHAs form a functional cation-translocating unit that is activated by PSKR1/BAK1 and possibly other BAK1/RLK complexes.

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Phytosulfokine Regulates Growth in Arabidopsis through a Response Module at the Plasma Membrane That Includes CYCLIC NUCLEOTIDE-GATED CHANNEL17, H⁺-ATPase, and BAK1

et al. 2015

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“…Plant cyclic nucleotide gated channels (CNGCs) have been proposed as candidates to conduct extracellular Ca 2+ into the cytosol (Sunkar et al, 2000;Talke et al, 2003;Lemtiri-Chlieh and Berkowitz, 2004;Ali et al, 2007;Demidchik and Maathuis, 2007;Frietsch et al, 2007;Kaplan et al, 2007;Ma and Berkowitz, 2007;Urquhart et al, 2007;Ma et al, 2009aMa et al, , 2009b. Arabidopsis "defense, no death" (dnd1) mutant plants have a null mutation in the gene encoding the plasma membranelocalized Ca 2+ -conducting CNGC2 channel.…”

mentioning

confidence: 99%

Leaf Senescence Signaling: The Ca2+-Conducting Arabidopsis Cyclic Nucleotide Gated Channel2 Acts through Nitric Oxide to Repress Senescence Programming

Smigel

Walker

et al. 2010

Plant Physiology

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Ca 2+ and nitric oxide (NO) are essential components involved in plant senescence signaling cascades. In other signaling pathways, NO generation can be dependent on cytosolic Ca 2+ . The Arabidopsis (Arabidopsis thaliana) mutant dnd1 lacks a plasma membrane-localized cation channel (CNGC2). We recently demonstrated that this channel affects plant response to pathogens through a signaling cascade involving Ca 2+ modulation of NO generation; the pathogen response phenotype of dnd1 can be complemented by application of a NO donor. At present, the interrelationship between Ca 2+ and NO generation in plant cells during leaf senescence remains unclear. Here, we use dnd1 plants to present genetic evidence consistent with the hypothesis that Ca 2+ uptake and NO production play pivotal roles in plant leaf senescence. Leaf Ca 2+ accumulation is reduced in dnd1 leaves compared to the wild type. Early senescence-associated phenotypes (such as loss of chlorophyll, expression level of senescence-associated genes, H 2 O 2 generation, lipid peroxidation, tissue necrosis, and increased salicylic acid levels) were more prominent in dnd1 leaves compared to the wild type. Application of a Ca 2+ channel blocker hastened senescence of detached wild-type leaves maintained in the dark, increasing the rate of chlorophyll loss, expression of a senescence-associated gene, and lipid peroxidation. Pharmacological manipulation of Ca 2+ signaling provides evidence consistent with genetic studies of the relationship between Ca 2+ signaling and senescence with the dnd1 mutant. Basal levels of NO in dnd1 leaf tissue were lower than that in leaves of wild-type plants. Application of a NO donor effectively rescues many dnd1 senescence-related phenotypes. Our work demonstrates that the CNGC2 channel is involved in Ca 2+ uptake during plant development beyond its role in pathogen defense response signaling. Work presented here suggests that this function of CNGC2 may impact downstream basal NO production in addition to its role (also linked to NO signaling) in pathogen defense responses and that this NO generation acts as a negative regulator during plant leaf senescence signaling.

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“…CNGCs are a relatively uncharacterized family of ion channels comprising of 20 members. 50,51 AtCNGC2 and 4 are the sole members of Group IVB, which is the most divergent group among the 20 member family of CNGCs. On the other hand, AtCNGC11 and 12, which are closest related to each other, belong to group I.…”

Section: The Ca 2+ Connectionmentioning

confidence: 99%

Lesion mimic mutants

Moeder

Yoshioka²

2008

Plant Signaling & Behavior

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CNGCs: prime targets of plant cyclic nucleotide signalling?

Cited by 219 publications

References 66 publications

Phytosulfokine Regulates Growth in Arabidopsis through a Response Module at the Plasma Membrane That Includes CYCLIC NUCLEOTIDE-GATED CHANNEL17, H⁺-ATPase, and BAK1

Phytosulfokine Regulates Growth in Arabidopsis through a Response Module at the Plasma Membrane That Includes CYCLIC NUCLEOTIDE-GATED CHANNEL17, H⁺-ATPase, and BAK1

Leaf Senescence Signaling: The Ca2+-Conducting Arabidopsis Cyclic Nucleotide Gated Channel2 Acts through Nitric Oxide to Repress Senescence Programming

Lesion mimic mutants

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CNGCs: prime targets of plant cyclic nucleotide signalling?

Cited by 219 publications

References 66 publications

Phytosulfokine Regulates Growth in Arabidopsis through a Response Module at the Plasma Membrane That Includes CYCLIC NUCLEOTIDE-GATED CHANNEL17, H+-ATPase, and BAK1

Phytosulfokine Regulates Growth in Arabidopsis through a Response Module at the Plasma Membrane That Includes CYCLIC NUCLEOTIDE-GATED CHANNEL17, H+-ATPase, and BAK1

Leaf Senescence Signaling: The Ca2+-Conducting Arabidopsis Cyclic Nucleotide Gated Channel2 Acts through Nitric Oxide to Repress Senescence Programming

Lesion mimic mutants

Contact Info

Product

Resources

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Phytosulfokine Regulates Growth in Arabidopsis through a Response Module at the Plasma Membrane That Includes CYCLIC NUCLEOTIDE-GATED CHANNEL17, H⁺-ATPase, and BAK1

Phytosulfokine Regulates Growth in Arabidopsis through a Response Module at the Plasma Membrane That Includes CYCLIC NUCLEOTIDE-GATED CHANNEL17, H⁺-ATPase, and BAK1