Nurse-led chemotherapy clinics are an essential part of UK oncology services. The approval of oral poly (adenosine diphosphate (ADP)-ribose) polymerase (PARP) inhibitors as maintenance treatment for people with platinum-responsive advanced ovarian cancer has provided patients with a new treatment option. However, due to their side effect profile, patients on these treatments require additional monitoring which can necessitate changes to the design of outpatient services. Nurse-led clinics designed specifically for patients receiving PARP inhibitors have been effective in addressing the additional monitoring requirements. This article provides a practical guide to developing a nurse-led telephone clinic for patients receiving PARP inhibitors for advanced ovarian cancer and other systemic anticancer treatments.