We introduce a multi-channel integrated circuit for fast Stimulated Raman Scattering (SRS) microscopy on multiple simultaneous frequencies at a frame rate higher than 1 frame/s. The chip is a 4-channel differential readout system, based on the lock-in technique. It is able to measure down to 10 ppm SRS signal, over a wide range of input optical powers (50 μW -600 μW per channel), with a pixel dwell time of only 30 μs. Each acquisition channel includes 2 low-noise preamplifiers, 2 variablegain amplifiers, a fully differential voltage subtractor and a lockin demodulator. The differential readout electronics rejects the power fluctuations of the laser and it is automatically balanced by an analog feedback loop over ± 30 % input power mismatches. Thanks to the autobalancing network, the pixel dwell time is reduced by a factor up to 225 with a settling time of only 10 μs. The chip is fabricated in AMS 0.35 μm CMOS technology and it is included in a combined electronics and optical system. Both single-pixel spectral measurements and multi-spectral imaging measurements are presented to validate the full SRS microscope.