CMOS monolithic microelectrode array for stimulation and recording of natural neural networks

Franks, Wendy; Heer, F. J. de; McKay, I.; Taschini, S.; Sunier, R.; Hagleitner, Christoph; Hierlemann, Andreas; Baltes, H.

doi:10.1109/sensor.2003.1216927

Cited by 25 publications

(10 citation statements)

References 6 publications

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“…Active devices, employing FETs were fabricated and 2D arrays demonstrated (Besl and Fromherz, 2002 ). Devices using CMOS technology were fabricated in academic facilities (DeBusschere and Kovacs, 2001 ) and industrial foundries, usually in conjunction with additional processing steps for biocompatibility reasons (Berdondini et al, 2002 ; Eversmann et al, 2003b ; Franks et al, 2003 ).…”

Section: Mea Technologymentioning

confidence: 99%

Revealing neuronal function through microelectrode array recordings

et al. 2015

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Microelectrode arrays and microprobes have been widely utilized to measure neuronal activity, both in vitro and in vivo. The key advantage is the capability to record and stimulate neurons at multiple sites simultaneously. However, unlike the single-cell or single-channel resolution of intracellular recording, microelectrodes detect signals from all possible sources around every sensor. Here, we review the current understanding of microelectrode signals and the techniques for analyzing them. We introduce the ongoing advancements in microelectrode technology, with focus on achieving higher resolution and quality of recordings by means of monolithic integration with on-chip circuitry. We show how recent advanced microelectrode array measurement methods facilitate the understanding of single neurons as well as network function.

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Section: Mea Technologymentioning

confidence: 99%

Revealing neuronal function through microelectrode array recordings

et al. 2015

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“…1) (Franks et al, 2003). Fabrication was performed using an industrial double-polysilicon, triple-metal, 0.6 m CMOS process at Austriamicrosystems AG (Austria).…”

Section: System Designmentioning

confidence: 99%

CMOS microelectrode array for the monitoring of electrogenic cells

Heer

Franks

Blau

et al. 2004

Biosensors and Bioelectronics

161

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Signal degradation and an array size dictated by the number of available interconnects are the two main limitations inherent to standalone microelectrode arrays (MEAs). A new biochip consisting of an array of microelectrodes with fully-integrated analog and digital circuitry realized in an industrial CMOS process addresses these issues. The device is capable of on-chip signal filtering for improved signal-to-noise ratio (SNR), on-chip analog and digital conversion, and multiplexing, thereby facilitating simultaneous stimulation and recording of electrogenic cell activity. The designed electrode pitch of 250 m significantly limits the space available for circuitry: a repeated unit of circuitry associated with each electrode comprises a stimulation buffer and a bandpass filter for readout. The bandpass filter has corner frequencies of 100 Hz and 50 kHz, and a gain of 1000. Stimulation voltages are generated from an 8-bit digital signal and converted to an analog signal at a frequency of 120 kHz. Functionality of the read-out circuitry is demonstrated by the measurement of cardiomyocyte activity. The microelectrode is realized in a shifted design for flexibility and biocompatibility. Several microelectrode materials (platinum, platinum black and titanium nitride) have been electrically characterized. An equivalent circuit model, where each parameter represents a macroscopic physical quantity contributing to the interface impedance, has been successfully fitted to experimental results.

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“…Finally, at this point it should be mentioned that the use of microelectronics and in particular of CMOS-based sensors in the field of cell recording techniques does not only open the way into new areas, but also makes it possible to improve the performance, robustness, and user-friendliness of known sensor configurations: Recently, Franks et al suggested a monolithically integrated MEA on the basis of a CMOS process with on-chip analog-to-digital and digital-to-analog conversion and further circuitry aiming for the above mentioned goals compared to the present passive approaches [46]. As a result, researchers are starting to identify significant DNA markers of therapeutic and prognostic value.…”

Section: Microelectronic Chips For Molecular and Cell Biologymentioning

confidence: 99%

Microelectronic Chips for Molecular and Cell Biology

et al. 2003

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The development of microfabricated devices manufactured in silicon, glass, or plastic materials is a well-known trend in the research of novel biological techniques and tools over the last two decades, resulting in a multitude of start-up companies serving the pharmaceutical, biotechnology, and diagnostics markets. However, the idea of implementing such devices on microelectronic substrates has been introduced only recently. This chapter aims to describe the state-of-the-art of microsystems for molecular and cell biology produced in general purpose CMOS (complementary metal oxide semiconductor) technology, emphasizing the advantages of this approach along with their challenges and limitations. This chapter discusses significant examples of fully tested devices in comparison with existing state-of-the-art techniques.

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CMOS monolithic microelectrode array for stimulation and recording of natural neural networks

Cited by 25 publications

References 6 publications

Revealing neuronal function through microelectrode array recordings

Revealing neuronal function through microelectrode array recordings

CMOS microelectrode array for the monitoring of electrogenic cells

Microelectronic Chips for Molecular and Cell Biology

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