CMOS Integrated DNA Chip for Quantitative DNA Analysis

Gemma, Nobuhiro; O’uchi, S.; Funaki, Hideyuki; Okada, Jun; Hongo, Sadato

doi:10.1109/isscc.2006.1696291

Cited by 15 publications

(9 citation statements)

References 3 publications

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“…We have realized a CMOS integrated electrochemical DNA chip which eliminates an extrinsic noise to the detection circuit and leads to a detection of low concentration of DNA [7]. By preparing sensors with different areas, it is possible to cover wide DNA concentration range.…”

Section: Cmos-integrated Dna Chipmentioning

confidence: 99%

Development of an Automated DNA Detection System Using an Electrochemical DNA Chip Technology

Hongo

Okada

Hashimoto

et al. 2008

SICE Journal of Control, Measurement, and System Integration

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: A new compact automated DNA detection system Genelyzer TM has been developed. After injecting a sample solution into a cassette with a built-in electrochemical DNA chip, processes from hybridization reaction to detection and analysis are all operated fully automatically. In order to detect a sample DNA, electrical currents from electrodes due to an oxidization reaction of electrochemically active intercalator molecules bound to hybridized DNAs are detected. The intercalator is supplied as a reagent solution by a fluid supply unit of the system. The feasibility test proved that the simultaneous typing of six single nucleotide polymorphisms (SNPs) associated with a rheumatoid arthritis (RA) was carried out within two hours and that all the results were consistent with those by conventional typing methods. It is expected that this system opens a new way to a DNA testing such as a test for infectious diseases, a personalized medicine, a food inspection, a forensic application and any other applications.

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Section: Cmos-integrated Dna Chipmentioning

confidence: 99%

Development of an Automated DNA Detection System Using an Electrochemical DNA Chip Technology

Hongo

Okada

Hashimoto

et al. 2008

SICE Journal of Control, Measurement, and System Integration

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“…In this case, integrated CMOS electronics have been a useful means to support a large number of capture probe sites on a single immobilization substrate [4][5][6][7][8]. CombiMatrix is one example of a company that attempted to commercialize electrochemical-based DNA assays based on CMOS active substrates [9].…”

Section: Introductionmentioning

confidence: 99%

Single-molecule electronic detection using nanoscale field-effect devices

Sorgenfrei

Shepard

2011

Proceedings of the 48th Design Automation Conference

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Traditionally, biomolecular systems have been studied in ensemble. While much can be determined with ensemble measurements, scientific and technological interest is rapidly moving to single-molecule techniques, which rely primarily on fluorescent markers and advanced microscopy techniques. In this paper, we describe recent work using nanoscale transistors based on carbon nanotubes as charge-sensitive detectors. We show carbon nanotubes can be used for ensemble studies through sidewall adsorption. Sensitivity can be greatly enhanced though an engineered defect in the nanotube. Biomolecular interactions are characterized by random-telegraph-noise response, which can be analyzed to study single-molecule kinetics and thermodynamics.

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“…IOSENSOR arrays have become important tools for highly parallel bioanalysis, and fully electronic biosensor arrays have been recently reported [1][2][3]. They can avoid expensive and bulky optical equipment and some [1], [2] even exclude costly labeling process.…”

Section: Introductionmentioning

confidence: 99%

“…They can avoid expensive and bulky optical equipment and some [1], [2] even exclude costly labeling process. These properties open the door to point-of-care diagnosis.…”

Section: Introductionmentioning

confidence: 99%

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A 64-channel readout ASIC for nanowire biosensor array with electrical calibration scheme

Chai

Choe

Bernal

et al. 2010

2010 Annual International Conference of the IEEE Engineering in Medicine and Biology

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A 1.8-mW, 18.5-mm(2) 64-channel current readout ASIC was implemented in 0.18-µm CMOS together with a new calibration scheme for silicon nanowire biosensor arrays. The ASIC consists of 64 channels of dedicated readout and conditioning circuits which incorporate correlated double sampling scheme to reduce the effect of 1/f noise and offset from the analog front-end. The ASIC provides a 10-bit digital output with a sampling rate of 300 S/s whilst achieving a minimum resolution of 7 pA(rms). A new electrical calibration method was introduced to mitigate the issue of large variations in the nano-scale sensor device parameters and optimize the sensor sensitivity. The experimental results show that the proposed calibration technique improved the sensitivity by 2 to 10 times and reduced the variation between dataset by 9 times.

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CMOS Integrated DNA Chip for Quantitative DNA Analysis

Cited by 15 publications

References 3 publications

Development of an Automated DNA Detection System Using an Electrochemical DNA Chip Technology

Development of an Automated DNA Detection System Using an Electrochemical DNA Chip Technology

Single-molecule electronic detection using nanoscale field-effect devices

A 64-channel readout ASIC for nanowire biosensor array with electrical calibration scheme

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