CMOS Bioelectronics: Current and Future Trends

Measuring and Modeling Macrophage Growth using a Lab-on-CMOS Capacitance Sensing Microsystem

“…In this paper, we describe the use of a lab-on-CMOS biosensor for studying macrophage dynamics in their growth phase. A lab-on-CMOS device is a platform that integrates lab-on-a-chip technology with complementary metal-oxide semiconductor (CMOS) chips for biosensing (Roussel et al ., 2006; Christen and Andreou, 2007; Sawan, Miled and Ghafar-Zadeh, 2010; Ghallab and Ismail, 2014; Yin, Li and Mason, 2016; Mason and Wan, 2017; Li, Yin and Mason, 2018; Lin et al ., 2022). The chips can feature circuits that are configured to transduce biophysical and biochemical events to the electrical domain and signal processing hardware for measurement, conditioning, and reporting.…”

Measuring and modeling macrophage proliferation in a lab-on-CMOS capacitance sensing microsystem

“…To facilitate in vitro studies of macrophage proliferation and to provide a tool for labelfree and real-time mechanistic investigations, we present herein an electronic microsystem, specifically, a lab-on-CMOS platform, that achieves real time macrophage proliferation monitoring using a capacitance-sensing bioelectronic interface. A lab-on-CMOS device is a platform that integrates lab-on-a-chip technology with complementary metal-oxide semiconductor (CMOS) chips for biosensing (Roussel et al, 2006;Christen and Andreou, 2007;Sawan et al, 2010;Ghallab and Ismail, 2014;Yin et al, 2016;Mason and Wan, 2017;Li et al, 2018;Lin et al, 2022). The chips can feature circuits that are configured to transduce biophysical and biochemical events to the electrical domain and signal processing hardware for measurement, conditioning, and reporting.…”