CMIP is a negative regulator of T cell signaling

Oniszczuk, Julie; Sendeyo, Kélhia; Chhuon, Cérina; Savas, Berkan; Cogné, Etienne; Vachin, Pauline; Hénique, Carole; Guerrera, Ida Chiara; Astarita, Giuseppe; Frontera, Vincent; Pawlak, André; Audard, Vincent; Sahali, Dil; Ollero, Mario

doi:10.1038/s41423-019-0266-5

Cited by 16 publications

(28 citation statements)

References 48 publications

(63 reference statements)

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“…CMIP is crucial in negatively regulating T-cell signaling pathway [31]. The participation of CMIP is observed in multiple cellular processes, such as chondrocyte terminal differentiation and cell growth in embryonic lens.…”

Section: Discussionmentioning

confidence: 99%

FOXC1-induced LINC01123 acts as a mediator in triple negative breast cancer

et al. 2020

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Background: MicroRNAs (miRNAs) representing a subclass of non-coding RNAs are dynamically expressed and participate in multiple pathological responses, whereas, the expression pattern or function of miRNAs has not been fully addressed in triple-negative breast cancer (TNBC). Currently we concentrate on dissecting the probable role of microRNA-663a (miR-663a) in TNBC cellular processes. Methods: qRT-PCR detected the expression of miR-663a in TNBC cells. Besides, we monitored the effects of miR-663a on TNBC proliferation and apoptosis. On the basis of bioinformatics assistance and mechanical validation, we identified the miRNA-sponging role of LINC01123 and downstream target of miR-663a in TNBC was assessed and verified. The transcription activation of was explored via ChIP and luciferase reporter assays. Results: In comparison to MCF-10A, we certified the downregulation of miR-663a in TNBC cell lines. Augmentation of miR-663a was anti-proliferation and pro-apoptosis in TNBC cell lines. LINC01123 protected CMIP against miR-663a suppression through acting as a sponge of miR-663a in TNBC. LINC01123 was transcriptionally induced by FOXC1. Rescue experiment proved that miR-663a suppression or CMIP (c-Maf inducing protein) enhancement could countervail LINC01123 depletion-mediated effects on TNBC cellular processes. Conclusion: LINC01123, activated by FOXC1, regulated TNBC growth through miR-663a/CMIP signaling, which unveiled a new functional pathway of FOXC1-induced LINC01123/miR-663a/CMIP in TNBC.

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Section: Discussionmentioning

confidence: 99%

FOXC1-induced LINC01123 acts as a mediator in triple negative breast cancer

et al. 2020

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“…In our work, we have found, along with a decrease in GM3, GM2, and GD3 in mouse podocytes transfected with human CMIP , an increased presence of LacCer, GlcCer, and several ceramides, consistent with a block in GM3 synthesis at the ST3Gal5/GM3 synthase level [ 7 ]. Our finding in mouse T-cells overexpressing human CMIP, consisting of a decrease in GM3 protein expression after 30 min of T-cell receptor (TCR) activation, seems to comfort the hypothesis of a GM3 synthesis blocking associated with CMIP overexpression.…”

Section: A Word By Ceramidesmentioning

confidence: 80%

“…Some individual features of the lipid composition of podocytes have been known for a long time, contributing to a progressive comprehension. Though a global view of the podocyte lipidome is still lacking, despite the information provided by a few lipidomic studies [ 6 , 7 , 8 ]. Cholesterol was early revealed as a key component of podocyte membrane.…”

Section: Podocytes: a Complex Structure And A Singular Membrane Ormentioning

confidence: 99%

“…Untargeted differential lipidomics of CMIP-expressing and non-expressing cells resulted, surprisingly, in a downregulation of the most abundant gangliosides (GM3, GM2, and GD2), while GM3 was identified as the most abundant podocyte component of the ganglio series. Interestingly, GM1 was not decreased [ 7 ]. The results suggested that an alteration in the pathway leading to ganglioside biosynthesis could play a role in the pathogenesis of INS.…”

Section: Gangliosides In Podocytesmentioning

confidence: 99%

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Gangliosides in Podocyte Biology and Disease

Savas

Astarita

Aureli

et al. 2020

IJMS

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Gangliosides constitute a subgroup of glycosphingolipids characterized by the presence of sialic acid residues in their structure. As constituents of cellular membranes, in particular of raft microdomains, they exert multiple functions, some of them capital in cell homeostasis. Their presence in cells is tightly regulated by a balanced expression and function of the enzymes responsible for their biosynthesis, ganglioside synthases, and their degradation, glycosidases. The dysregulation of their abundance results in rare and common diseases. In this review, we make a point on the relevance of gangliosides and some of their metabolic precursors, such as ceramides, in the function of podocytes, the main cellular component of the glomerular filtration barrier, as well as their implications in podocytopathies. The results presented in this review suggest the pertinence of clinical lipidomic studies targeting these metabolites.

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“…Recent studies have shown that CIMP is closely associated with TC, LDL-C, and HDL-C levels and with Type 2 diabetes and acute myocardial infarction. It is currently thought that this gene primarily acts on the T-cell signalling pathway [ 32 ]. The T-cell receptor (TCR) alpha constant gene encodes the constant region of the T-cell receptor [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

CMIPSNPs and their haplotypes are associated with dyslipidaemia and clinicopathologic features of IgA nephropathy

Pan

Liao

et al. 2020

Bioscience Reports

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The relationship between serum lipid profiles and related clinicopathologic features of IgA nephropathy (IgAN) and c-Maf-inducing protein (CMIP) gene polymorphisms is unclear. This study was designed to examine the effect of CMIP single nucleotide polymorphisms (SNPs) on dyslipidaemia and clinicopathologic features of IgAN. Clinical and pathological data from patients with IgAN diagnosed at the First Affiliated Hospital of Guangxi Medical University were collected. DNA was extracted from blood samples. CMIP rs2925979 and CMIP rs16955379 genotypes were determined by PCR and direct sequencing. Among 543 patients, 281 had dyslipidaemia (51.7%). Compared to the non-dyslipidaemia group, the dyslipidaemia group exhibited higher blood pressure, blood urea nitrogen, uric acid, and body mass index; higher prevalence of oedema, haematuria, tubular atrophy, and interstitial fibrosis; and lower albumin and estimated glomerular filtration rate. In the dyslipidaemia group, the frequency of C allele carriers was higher than that of non-C allele carriers for rs16955379. Multivariate linear regression analysis showed that total cholesterol, low-density lipoprotein and high-density lipoprotein were associated with rs16955379C allele carriers. Apolipoprotein B was associated with A allele carriers of rs2925979. Linkage disequilibrium was observed between rs16955379 and rs2925979, and rs2925979G-rs16955379T was the most common haplotype. The frequencies of the four CMIP SNP haplotypes differed between dyslipidaemia and non-dyslipidaemia groups in IgAN (P < 0.05, for all above). Dyslipidaemia is a common complication in IgAN patients, and those with dyslipidaemia present poor clinicopathologic features. CMIP SNPs and their haplotypes are closely correlated with the occurrence of dyslipidaemia and clinicopathologic damage in IgAN patients.

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CMIP is a negative regulator of T cell signaling

Cited by 16 publications

References 48 publications

FOXC1-induced LINC01123 acts as a mediator in triple negative breast cancer

FOXC1-induced LINC01123 acts as a mediator in triple negative breast cancer

Gangliosides in Podocyte Biology and Disease

CMIPSNPs and their haplotypes are associated with dyslipidaemia and clinicopathologic features of IgA nephropathy

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