cMiCE: a high resolution animal PET using continuous LSO with a statistics based positioning scheme

Joung, Jinhun; Miyaoka, Robert S.; Lewellen, T.K.

doi:10.1016/s0168-9002(02)00861-6

Cited by 155 publications

(139 citation statements)

References 9 publications

Supporting

Mentioning

133

Contrasting

Unclassified

Order By: Relevance

“…This means that one can use (together with appropriate regularization) much more flexible non-parametric LRF representations such as look-up table [20] or cubic spline [23] previously used only in conjunction with the direct scan method. The cubic spline has an additional advantage of being a smooth function and, as we have found, with appropriate choice of knots it does not require any additional regularization.…”

Section: Discussionmentioning

confidence: 99%

Position reconstruction in a dual phase xenon scintillation detector

Solovov¹,

Belov²,

Akimov³

et al. 2011

2011 IEEE Nuclear Science Symposium Conference Record

View full text Add to dashboard Cite

Abstract-We studied the application of statistical reconstruction algorithms, namely maximum likelihood and least squares methods, to the problem of event reconstruction in a dual phase liquid xenon detector. An iterative method was developed for in-situ reconstruction of the PMT light response functions from calibration data taken with an uncollimated γ-ray source. Using the techniques described, the performance of the ZEPLIN-III dark matter detector was studied for 122 keV γ-rays. For the inner part of the detector (R<100 mm), spatial resolutions of 13 mm and 1.6 mm FWHM were measured in the horizontal plane for primary and secondary scintillation, respectively. An energy resolution of 8.1% FWHM was achieved at that energy. The possibility of using this technique for improving performance and reducing cost of scintillation cameras for medical applications is currently under study.

show abstract

Section: Discussionmentioning

confidence: 99%

Position reconstruction in a dual phase xenon scintillation detector

Solovov¹,

Belov²,

Akimov³

et al. 2011

2011 IEEE Nuclear Science Symposium Conference Record

View full text Add to dashboard Cite

show abstract

“…An alternative approach that can reduce both complexity and cost is based on a monolithic crystal PET detector design [7][8][9][10][11][12][13][14][15]. The continuous miniature crystal element (cMiCE) detector [9,16,17] is similar in concept to the modular gamma camera detector that had previously been developed at the University of Arizona [18].…”

Section: Introductionmentioning

confidence: 99%

Resolution properties of a prototype continuous miniature crystal element (cMiCE) scanner

Miyaoka

Pierce

et al. 2010

IEEE Nuclear Science Symposuim &Amp; Medical Imaging Conference

View full text Add to dashboard Cite

Continuous miniature crystal element (cMiCE) detectors are a potentially lower cost alternative for high resolution discrete crystal PET detector designs. We report on performance characteristics of a prototype PET scanner consisting of two cMiCE detector modules. Each cMiCE detector is comprised of a 50 × 50 × 8 mm 3 LYSO crystal coupled to a 64 channel multi-anode PMT. The cMiCE detectors use a statistics-based positioning method based upon maximum likelihood estimation for event positioning. By this method, cMiCE detectors can also provide some depth of interaction event positioning information. For the prototype scanner, the cMiCE detectors were positioned across from one another on a horizontal gantry with a detector spacing of 10.7 cm. Full tomographic data were collected and reconstructed using single slice rebinning and filtered back projection with no smoothing. The average image resolutions in X (radial), Y (transverse) and Z (axial) were 1.05 ± 0.08 mm, 0.99 ± 0.07 mm, 1.24 ± 0.31 mm FWHM. These initial imaging results from a prototype imaging system demonstrate the outstanding image resolution performance that can be achieved using the potentially lower cost cMiCE detectors.

show abstract

“…In our previous work, 1) we explored a continuous miniature crystal element (cMiCE) detector consisting of a 25 mm by 25 mm by 4 mm slab of LSO coupled to a position-sensitive PMT. In that study, we introduced a statisticsbased positioning (SBP) algorithm that improved the positioning characteristics near the edge of the crystal.…”

Section: Introductionmentioning

confidence: 99%

Detector Light Response Modeling for a Thick Continuous Slab Detector

Miyaoka

Joo

Lee

2008

J. Nucl. Sci. Technol.

Self Cite

View full text Add to dashboard Cite

We investigate a method to improve the position decoding for thick crystal versions (i.e., ≥8 mm) of the continuous miniature crystal element (cMiCE) PET detector by more accurately modeling the detector light response function (LRF). The LRF for continuous detectors varies with the depth of interaction (DOI) of the detected photon. This variation in LRF can result in a positioning error for two-dimensional positioning algorithms. We explore a method to improve positioning performance by deriving two lookup tables, corresponding to the front and back regions of the crystal. The DETECT2000 simulation package was used to investigate the light response characteristics for a 48.8 mm by 48.8 mm by 10 (8) mm slab of LSO coupled to a 64-channel, flat-panel PMT. The data are then combined to produce the two-dimensional light collection histograms. Light collection histograms that have markedly non-Gaussian distributions are characterized as a combination of two Gaussian functions, where each Gaussian function corresponds to a DOI region of the crystal. The results indicate that modest gains in positioning accuracy are achieved near the central region of the crystal. However, significant improvements in spatial resolution and positioning bias are achieved for the corner section of the detector.

show abstract

cMiCE: a high resolution animal PET using continuous LSO with a statistics based positioning scheme

Cited by 155 publications

References 9 publications

Position reconstruction in a dual phase xenon scintillation detector

Position reconstruction in a dual phase xenon scintillation detector

Resolution properties of a prototype continuous miniature crystal element (cMiCE) scanner

Detector Light Response Modeling for a Thick Continuous Slab Detector

Contact Info

Product

Resources

About