cMiCE:a high resolution animal PET using continuous LSO with a statistics based positioning scheme

Joung, Jinhun; Miyaoka, Robert S.; Lewellen, T.K.

doi:10.1109/nssmic.2001.1009751

Cited by 13 publications

(13 citation statements)

References 24 publications

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“…They are also characterized by the highest light output (i.e., number of photons emitted per unit of deposited energy), which is directly related to the energy resolution. Most PET and SPECT systems are composed of pixelated scintillators to assign the interaction position of the gamma photon [74], although blocks made of continuous crystal have been proposed as well [75,76]. Table 3 lists some of the scintillators commonly used in CT, SPECT and PET detector systems together with their key properties [77][78][79][80][81].…”

Section: Detector Technology For Ct Spect and Petmentioning

confidence: 99%

Hybrid Imaging: Instrumentation and Data Processing

et al. 2018

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State-of-the-art patient management frequently requires the use of non-invasive imaging methods to assess the anatomy, function or molecular-biological conditions of patients or study subjects. Such imaging methods can be singular, providing either anatomical or molecular information, or they can be combined, thus, providing "anato-metabolic" information. Hybrid imaging denotes image acquisitions on systems that physically combine complementary imaging modalities for an improved diagnostic accuracy and confidence as well as for increased patient comfort. The physical combination of formerly independent imaging modalities was driven by leading innovators in the field of clinical research and benefited from technological advances that permitted the operation of PET and MR in close physical proximity, for example. This review covers milestones of the development of various hybrid imaging systems for use in clinical practice and small-animal research. Special attention is given to technological advances that helped the adoption of hybrid imaging, as well as to introducing methodological concepts that benefit from the availability of complementary anatomical and biological information, such as new types of image reconstruction and data correction schemes. The ultimate goal of hybrid imaging is to provide useful, complementary and quantitative information during patient work-up. Hybrid imaging also opens the door to multi-parametric assessment of diseases, which will help us better understand the causes of various diseases that currently contribute to a large fraction of healthcare costs.

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Section: Detector Technology For Ct Spect and Petmentioning

confidence: 99%

Hybrid Imaging: Instrumentation and Data Processing

et al. 2018

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“…8). More intelligent positioning algorithms [14] are under investigation to expand the dynamic range of the sheet crystal positioning and improve linearity near the FOV edge. Note the measured dynamic range also improves by 28% if we remove the crystal edge reflector, but this reduces the measured light collection by 27% and energy resolution by 16%.…”

Section: Summary and Discussionmentioning

confidence: 99%

“…The devices were fabricated using a planar process similar to that used for APD array fabrication [13]. The prototype PSAPD devices have a sensitive area of 8 8 and 14 14 . Packaged on a ceramic substrate they are thick.…”

Section: B Position Sensitive Avalanche Photodiode (Psapd) Configuramentioning

confidence: 99%

“…This operating bias provides the best 511 keV photopeak energy resolution in both devices. The PSAPD device capacitances are and 140 pf (0.7 ), the leakage current at operating bias is -and 1-2 , and the rms noise is and 140 electrons, respectively, for the 8 8 and 14 14 devices. The quantum efficiency of these devices are for the 420 nm peak emission wavelength of LSO.…”

Section: B Position Sensitive Avalanche Photodiode (Psapd) Configuramentioning

confidence: 99%

“…Each event was positioned with Anger-type logic. The coincidence time measurements were performed in a standard manner using a PMT coupled to a 6 6 8 LSO crystal to provide the start signal for a time-to-amplitude converter (TAC) with the TAC stop determined from a 8 8 2 LSO sheet coupled to the 8 8 or 14 14 PSAPD. side-on to the PSAPD; this configuration facilitates a 3 mm interaction depth resolution.…”

Section: Measurementsmentioning

confidence: 99%

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Investigation of position sensitive avalanche photodiodes for a new high-resolution PET detector design

Levin

Foudray

Olcott

et al. 2004

IEEE Trans. Nucl. Sci.

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We are developing a high-resolution PET detector design with a goal of nearly complete scintillation light collection in 1 mm width, 20 mm effective thickness LSO crystals.The design uses position sensitive avalanche photodiodes in novel layered configurations that significantly improve the light collection aspect ratio. To reduce design complexity and dead area we are investigating the use of 1 mm thick sheets of LSO in addition to discrete crystal rods, and the use of PSAPDs which require only four readout channels per device. The raw spatial response of a 1 mm thick crystal sheet coupled to a PSAPD exhibits a compressed dynamic range compared to that observed with discrete crystals.Measurements with the proposed configurations using 22 Na irradiation achieved 10%-13% FWHM energy resolution at 511 keV and 2 ns coincidence time resolution. 1 mm width crystals with a saw cut surface finish an no inter-crystal reflector were well resolved in flood images.

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