Clustering of symptoms associated with fibromyalgia in a Finnish Twin Cohort

Markkula, Ritva; Järvinen, Pentti A.; Leino-Arjas, Päivi; Koskenvuo, Markku; Kalso, Eija; Kaprio, Jaakko

doi:10.1016/j.ejpain.2008.09.007

Cited by 54 publications

(40 citation statements)

References 43 publications

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“…Although this may be due to shared environmental or behavioral factors, it suggests that there may be a genetic predisposition to FMS. Indeed, according to data from large adult Swedish and Finnish twin cohorts, genetics account for approximately half of the risk of CWP [447] or of being affected by a cluster of symptoms associated with FMS [448]. Shared family environment was found to have essentially no influence [447].…”

Section: Potential Pathogenetic Mechanisms Genetics and Epigeneticsmentioning

confidence: 99%

Fibromyalgia: A Critical and Comprehensive Review

Borchers

Gershwin

2015

Clinic Rev Allerg Immunol

224

217

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Fibromyalgia is a disorder that is part of a spectrum of syndromes that lack precise classification. It is often considered as part of the global overview of functional somatic syndromes that are otherwise medically unexplained or part of a somatization disorder. Patients with fibromyalgia share symptoms with other functional somatic problems, including issues of myalgias, arthralgias, fatigue and sleep disturbances. Indeed, there is often diagnostic and classification overlap for the case definitions of a variety of somatization disorders. Fibromyalgia, however, is a critically important syndrome for physicians and scientists to be aware of. Patients should be taken very seriously and provided optimal care. Although inflammatory, infectious, and autoimmune disorders have all been ascribed to be etiological events in the development of fibromyalgia, there is very little data to support such a thesis. Many of these disorders are associated with depression and anxiety and may even be part of what has been sometimes called affected spectrum disorders. There is no evidence that physical trauma, i.e., automobile accidents, is associated with the development or exacerbation of fibromyalgia. Treatment should be placed on education, patient support, physical therapy, nutrition, and exercise, including the use of drugs that are approved for the treatment of fibromyalgia. Treatment should not include opiates and patients should not become poly pharmacies in which the treatment itself can lead to significant morbidities. Patients with fibromyalgia are living and not dying of this disorder and positive outlooks and family support are key elements in the management of patients.

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Section: Potential Pathogenetic Mechanisms Genetics and Epigeneticsmentioning

confidence: 99%

Fibromyalgia: A Critical and Comprehensive Review

Borchers

Gershwin

2015

Clinic Rev Allerg Immunol

224

217

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“…Significant familial aggregation, convincing demonstrations of genetic linkages and associations demonstrate an underlying genetic basis for FMS (Ablin et al, 2006). In two twin studies of chronic widespread pain, the heritability of chronic pain symptoms was estimated 48-54% and 51% (Kato et al, 2006;Markkula et al, 2009). Many studies have examined the potential contribution of the candidate gene polymorphisms to FMS susceptibility, but these studies have produced diverse results (Lee et al, 2012;Tammimäki & Männistö, 2012).…”

Section: Introductionmentioning

confidence: 95%

Clinical symptoms in fibromyalgia are associated to catechol-O-methyltransferase (COMT) gene Val158Met polymorphism

Inanir

Karakuş²,

Ateş³

et al. 2014

Xenobiotica

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1. Fibromyalgia syndrome (FMS) is a common chronic widespread pain syndrome mainly affecting women. The aim of this study was to explore the frequency and clinical significance of catechol-O-methyltransferase (COMT) gene Val158Met polymorphism in a large cohort of Turkish patients with FMS. 2. The study included 379 FMS patients and 290 controls. Genomic DNA was isolated and genotyped using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analyses. 3. The genotype frequencies of Val158Met polymorphism showed a small difference between FMS patients and healthy controls (p = 0.047), however, the Met/Met genotype was significantly higher in FMS patients than healthy controls (p = 0.016). No difference was observed for allele frequencies between two groups. Stratification analysis according to clinical features for this disease reveals that weight, FMS Impact Questionnaire score, algometry and Raynaud's syndrome, were detected to have statistically significant associations with Val158Met polymorphism (p = 0.037, p = 0.042, p = 0.039 and p = 0.033, respectively). Pain sensitivity, measured by algometry, was statistically higher in patients with Met/Met genotype than the patients with Val/Val and Val/Met genotypes (p = 0.017). 4. The results of this study suggested that COMT gene Val158Met polymorphism is positively associated with FMS and play a relevant role in the clinical symptoms of the disease.

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“…The identified risk factors can be grouped into at least four categories: genetic, somatic, psychological, and stressful events. Heritability of FM is approximately 50% [59]. The genetic polymorphisms that have thus far most reliably been identified as to be related to FM/CWP are located in pathways that have been implicated in FM in other lines of research, specifically the adrenergic and serotonergic system.…”

Section: Present Evidencementioning

confidence: 99%

Programmed Symptoms: Disparate Effects United by Purpose

Gracely¹,

Schweinhardt

2015

CRR

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Central sensitivity syndromes (CSS) share features of similar multiple symptoms, virtually unknown mechanisms and lack of effective treatments. The CSS nomenclature was chosen over alternatives because it focused on a putative physiological mechanism of central sensitization common to disorders such as fibromyalgia, irritable bowel syndrome, vulvodynia and temporomandibular disorder. Increasing evidence from multiple biological systems suggests a further development. In this new model central sensitization is part of a ensemble that includes also the symptoms of widespread pain, fatigue, unrefreshing sleep and dyscognition. The main feature is an intrinsic program that produces this ensemble to guide behavior to restore normal function in conditions that threaten survival. The well known “illness response” is a classic example that is triggered in response to the specific threat of viral infection. The major leap for this model in the context of CSS is that the symptom complex is not a reactive result of pathology, but a purposeful feeling state enlisted to combat pathology. Once triggered, this state is produced by potential mechanisms that likely include contributions of the peripheral and central immune systems, as well as stress response systems such as the autonomic system and the hypothalamic–pituitary–adrenal (HPA) axis. These act in concert to alter behavior in a beneficial direction. This concept explains similar symptoms for many triggering conditions, the poorly understood pathology, and the resistance to treatment.

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Clustering of symptoms associated with fibromyalgia in a Finnish Twin Cohort

Cited by 54 publications

References 43 publications

Fibromyalgia: A Critical and Comprehensive Review

Fibromyalgia: A Critical and Comprehensive Review

Clinical symptoms in fibromyalgia are associated to catechol-O-methyltransferase (COMT) gene Val158Met polymorphism

Programmed Symptoms: Disparate Effects United by Purpose

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