Clustering of Necrotizing Enterocolitis

Book, Linda S.; Overall, James C.; Herbst, John J.; Britt, Michael R.; Epstein, Beverly; Jung, August L.

doi:10.1056/nejm197711032971805

Cited by 91 publications

(9 citation statements)

References 8 publications

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“…We did not observe the``typical'' clustering of NEC reported by other investigators [7,8,21]. None of these earlier studies, however, applied statistical methods to prove that NEC occurrences were indeed non-homogenously distributed over time (the latter would suggest that NEC is an infectious disease).…”

Section: Discussioncontrasting

confidence: 76%

Necrotising enterocolitis: is there a relationship to specific pathogens?

Peter

Feuerhahn

Bohnhorst

et al. 1999

European Journal of Pediatrics

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Section: Discussioncontrasting

confidence: 76%

Necrotising enterocolitis: is there a relationship to specific pathogens?

Peter

Feuerhahn

Bohnhorst

et al. 1999

European Journal of Pediatrics

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“…This can be partially explained by the increased numbers of VLBW infants (birth-weight < 1,500 g) who developed NEC (53% in 1985 compared with 15% in the years 1981-1984 and 37% in 1976-1980). The hypothesis for an infectious cause of such epidemics remains inconclusive, as no consistent pathogen, bacterial or viral has been isolated (6). However, it has been observed that anti-infectious control measures helped to stop such epidemics (6) and antibiotic treatment was associated with decreased risk and later onset of the disease (7).…”

Section: Discussionmentioning

confidence: 99%

Necrotizing Enterocolitis: A 15‐Year Experience

Leong

Drew

1987

Aust NZ J Obst Gynaeco

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Eighty-seven infants (0.13% of livebirths) developed necrotizing enterocolitis (NEC) during a 15-year period at the Mercy Maternity Hospital, Melbourne. The disease was associated with 23 deaths, representing a mortality rate of 26.4% and comprising 2.6% of all neonatal deaths. The incidence of NEC increased from 0.07% of all livebirths for the years 1971-1974 to 0.25% for the 19-month period from January, 1984 to July, 1985. The mean age at onset was 9.9 days with an inverse relationship between birth-weight and age of onset of the disease. The mothers of the infants who developed NEC belonged to a significantly higher risk obstetric population; gestational diabetes was identified in 3 of 28 mothers (10.6%) having glucose tolerance tested, and 1 other patients was a known diabetic. Subnormal oestriol excretion was detected in 15 of 45 patients tested, treble the overall hospital incidence. Of the 87 infants, 26 (29.9%) were VLBW (birth-weight less than 1,500 g), 5 were term (5.7%) and 9 (10.3%) were small for gestational age. The mean gestational age was 34.7 weeks and mean birth-weight was 1,988 g. Sixty-seven (77%) infants received medical treatment alone and 20 (23%) also received surgical treatment. Sequelae which developed in survivors were colonic strictures (4), fistulas (2) and the short-gut syndrome (1).

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“…The decrease did not coincide with the admission of more mature infants or infants with lesser problems, as can be concluded from the need for mechanical ventilation and the incidence of PDA. NEC is reported to occur in epidemic episodes (6). From the 4-year period in which the disease has practically vanished from our unit we conclude that it is not likely to be a temporary decrease.…”

mentioning

confidence: 52%