Abstract:Clustering of neuronal L-type voltage-gated Ca2+channels (LTCC) in the plasma membrane is increasingly implicated in creating highly localized Ca2+signaling nanodomains. For example, LTCC activation can increase phosphorylation of the nuclear CREB transcription factor by increasing Ca2+concentrations within a nanodomain close to the channel, without requiring bulk Ca2+increases in the cytosol or nucleus. However, the molecular basis for LTCC clustering is poorly understood. The postsynaptic scaffolding protein… Show more
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