Clustering of autoimmune disease in parents of siblings from the Type 1 diabetes Warren repository

Tait, Karen; Marshall, Tom; Berman, Julia; Carr-Smith, James; Rowe, B R; Todd, John A.; Bain, Stephen C.; Barnett, Anthony; Gough, Stephen

doi:10.1111/j.1464-5491.2004.01162.x

Cited by 75 publications

(50 citation statements)

References 17 publications

(24 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Given evidence that treatment of pre-diabetes can prevent diabetes, 59 lack of diabetes screening is a missed opportunity to prevent diabetes. 60 …”

Section: Screening For Type 2 Diabetes and Other Cardiovascular Diseamentioning

confidence: 99%

Diabetes and Cardiovascular Care Among People with Severe Mental Illness: A Literature Review

et al. 2016

View full text Add to dashboard Cite

Close to 19 million US adults have severe mental illnesses (SMI), and they die, on average, 25 years earlier than the general population, most often from cardiovascular disease (CVD). Many of the antipsychotic medications used to treat SMI contribute to CVD risk by increasing risk for obesity, type 2 diabetes, dyslipidemia, and hypertension. Based on compelling evidence, the American Diabetes Association and the American Psychiatric Association developed guidelines for metabolic screening and monitoring during use of these medications. In this manuscript, we have reviewed the evidence on diabetes and other CVD risk screening, prevalence, and management among populations with SMI. We also review differences in screening among subpopulations with SMI (e.g., racial/ethnic minorities, women, and children). We found that despite national guidelines for screening for diabetes and other cardiovascular risk factors, up to 70 % of people taking antipsychotics remain unscreened and untreated. Based on estimates that 20 % of the 19 million US adults with SMI have diabetes and 70 % of them are not screened; it is likely that over 2 million Americans with SMI have unidentified diabetes. Given that undiagnosed diabetes costs over $4,000 per person, this failure to identify diabetes among people with SMI represents a missed opportunity to prevent morbidity and translates to over $8 billion in annual preventable costs to our healthcare system. Given the high burden of disease and significant evidence of suboptimal medical care received by people with SMI, we propose several clinical and policy recommendations to improve diabetes and other CVD risk screening and care for this highly vulnerable population. These recommendations include reducing antipsychotic medication dose or switching antipsychotic medications, enhancing smoking cessation efforts, sharing electronic health records between physical and mental health care systems, and promoting integration of care.KEY WORDS: mental illness; diabetes; integration of care.

show abstract

“…Given evidence that treatment of pre-diabetes can prevent diabetes, 59 lack of diabetes screening is a missed opportunity to prevent diabetes. 60 …”

Section: Screening For Type 2 Diabetes and Other Cardiovascular Diseamentioning

confidence: 99%

Diabetes and Cardiovascular Care Among People with Severe Mental Illness: A Literature Review

et al. 2016

View full text Add to dashboard Cite

show abstract

“…There is increasing evidence that autoimmune diseases share some common risk factors. Evidence for shared susceptibility genes is obtained from the observation that several autoimmune diseases tend to cluster in the same families, 1 and also that the chromosomal regions showing linkage to autoimmune diseases tend to overlap. 2,3 Consequently, when a potential risk factor for an autoimmune disease is discovered, it is of interest to investigate whether the novel risk factor is also involved in other autoimmune diseases.…”

Section: Introductionmentioning

confidence: 99%

Association analysis of the 1858C>T polymorphism in the PTPN22 gene in juvenile idiopathic arthritis and other autoimmune diseases

et al. 2005

View full text Add to dashboard Cite

A functional single nucleotide polymorphism, 1858C4T, in the PTPN22 gene, encoding a tyrosine phosphatase, has been reported to be associated with type I diabetes and some other autoimmune diseases. To further investigate whether this polymorphism may be a general susceptibility factor for autoimmunity, we performed an association study in five different autoimmune diseases, three previously not tested. We found an association with juvenile idiopathic arthritis (OR ¼ 1.41; P ¼ 0.04), not previously reported, and a tendency for an association with coeliac disease (OR ¼ 1.35; P ¼ 0.08). In primary sclerosing cholangitis, no association was observed (OR ¼ 0.95; P ¼ 0.8). Furthermore, we confirmed the increased risk in rheumatoid arthritis (OR ¼ 1.58; P ¼ 0.001), but could not find support for an association with systemic lupus erythematosus (OR ¼ 0.94; P ¼ 0.8). Altogether, we have provided further evidence of an association between autoimmune diseases and the 1858C4T polymorphism in PTPN22.

show abstract

“…Clinically different autoimmune phenotypes may share common susceptibility genes, which may act as risk factors for autoimmunity. Evidence for shared susceptibility genes is obtained from the observation that several autoimmune diseases tend to cluster in the same families 1,2 and also that the chromosomal regions showing linkage to autoimmune diseases tend to overlap. 3,4 One of the key points in the pathogenesis of autoimmune diseases is the regulation of the T-cell response.…”

Section: Introductionmentioning

confidence: 99%

PTPN22 C1858T polymorphism in Colombian patients with autoimmune diseases

Anaya

et al. 2005

Genes Immun

110

View full text Add to dashboard Cite

Clustering of autoimmune disease in parents of siblings from the Type 1 diabetes Warren repository

Abstract: These data confirm the importance of family history as a significant risk factor for the development of Type 1 diabetes and support the hypothesis that the common autoimmune diseases share at least some aetiological mechanisms.

Cited by 75 publications

References 17 publications

Diabetes and Cardiovascular Care Among People with Severe Mental Illness: A Literature Review

Diabetes and Cardiovascular Care Among People with Severe Mental Illness: A Literature Review

Association analysis of the 1858C>T polymorphism in the PTPN22 gene in juvenile idiopathic arthritis and other autoimmune diseases

PTPN22 C1858T polymorphism in Colombian patients with autoimmune diseases

Contact Info

Product

Resources

About