Clusterin Plasma Concentrations Are Decreased in Sepsis and Inversely Correlated with Established Markers of Inflammation

Yagmur, Eray; Jhaisha, Samira Abu; Buendgens, Lukas; Sapundzhieva, Nadezhda; Brozat, Jonathan F.; Hohlstein, Philipp; Pollmanns, Maike R.; Koek, Ger H.; Weiskirchen, Ralf; Tacke, Frank; Wirtz, Theresa H.; Koch, Alexander

doi:10.3390/diagnostics12123010

Cited by 6 publications

(5 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Written informed consent was obtained from the patient, their spouse, or an appointed legal guardian. Patients above the age of 18 with available blood samples on the day of ICU admission were included, as previously described [59][60][61][62]. Exclusion criteria included expected short-term ICU treatment (<48 h), admission from another ICU, acute poisoning, and pregnancy.…”

Section: Methodsmentioning

confidence: 99%

Soluble Neuropilin-1 Is Elevated in Sepsis and Correlates with Organ Dysfunction and Long-Term Mortality in Critical Illness

Hohlstein,

Schumacher,

Abu Jhaisha

et al. 2024

IJMS

Self Cite

View full text Add to dashboard Cite

Critical illness and sepsis may cause organ failure and are recognized as mortality drivers in hospitalized patients. Neuropilin-1 (NRP-1) is a multifaceted transmembrane protein involved in the primary immune response and is expressed in immune cells such as T and dendritic cells. The soluble form of NRP-1 (sNRP-1) acts as an antagonist to NRP-1 by scavenging its ligands. The aim of this study was to determine the value of sNRP-1 as a biomarker in critical illness and sepsis. We enrolled 180 critically ill patients admitted to a medical intensive care unit and measured serum sNRP-1 concentrations at admission, comparing them to 48 healthy individuals. Critically ill and septic patients showed higher levels of sNRP-1 compared to healthy controls (median of 2.47 vs. 1.70 nmol/L, p < 0.001). Moreover, sNRP-1 was also elevated in patients with sepsis compared to other critical illness (2.60 vs. 2.13 nmol/L, p = 0.01), irrespective of disease severity or organ failure. In critically ill patients, sNRP-1 is positively correlated with markers of kidney and hepatic dysfunction. Most notably, critically ill patients not surviving in the long term (one year after admission) showed higher concentrations of sNRP-1 at the time of ICU admission (p = 0.036), with this association being dependent on the presence of organ failure. Critically ill and septic patients exhibit higher serum concentrations of circulating sNRP-1, which correlates to organ failure, particularly hepatic and kidney dysfunction.

show abstract

Section: Methodsmentioning

confidence: 99%

Soluble Neuropilin-1 Is Elevated in Sepsis and Correlates with Organ Dysfunction and Long-Term Mortality in Critical Illness

Hohlstein,

Schumacher,

Abu Jhaisha

et al. 2024

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…We included 192 patients admitted to our medical intensive care unit of the Department of Gastroenterology, Digestive Disease and Intensive Care Medicine. Patients with consent, who were above or equal to the age of 18 years, were included in this study, as described previously [ 49 , 50 ]. We excluded (a) patients with expected short-term (less than 48 h) intensive care treatment, (b) patients admitted from another ICU and (c) patients admitted due to acute poisoning.…”

Section: Methodsmentioning

confidence: 99%

Elevated Midkine Serum Levels Are Associated with Long-Term Survival in Critically Ill Patients

Hohlstein,

Abu Jhaisha,

Yagmur

et al. 2023

IJMS

Self Cite

View full text Add to dashboard Cite

Midkine (Mdk) is a multifunctional protein involved in inflammatory processes. Hence, circulating Mdk is increased in sepsis and has been previously suggested as a potential biomarker in these patients. The aim of this study was to elucidate the role of Mdk serum concentrations in critical illness and sepsis and to verify its value as a prognostic biomarker. Thus, we analyzed the Mdk serum concentrations of 192 critically ill patients on admission to the medical intensive care unit (ICU). While the serum levels of Mdk at admission were similar in septic and nonseptic critical illness (362 vs. 337 ng/L, p = 0.727), we found several interesting correlations of Mdk to laboratory and clinical markers associated with ischemia or hypoxia, e.g., to renal failure and hepatic injury. Mdk serum concentrations at admission did not differ between various causes of sepsis or other critical illness. Most noticeable, we observed upregulated Mdk serum concentrations at admission in patients surviving in the long-term, which was only seen in nonseptic critical illness but not in sepsis. Our study suggests a relevant role of Mdk in critically ill patients in general and highlights the possible protective features of Mdk in critical illness.

show abstract

“…Patients above 18 years of age and with written informed consent for inclusion in the study (from the patient, their spouse or appointed legal guardian) were considered for inclusion. Patients with an expected short-term ICU stay (<48 h), patients admitted from another ICU and patients with poisoning were excluded, as previously described [22][23][24]. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) were used to differentiate between septic and non-septic patients, and treatment was conducted according to guidelines [25].…”

Section: Selection and Inclusion Of Patientsmentioning

confidence: 99%

Soluble Semaphorin 4D Serum Concentrations Are Elevated in Critically Ill Patients with Liver Cirrhosis and Correlate with Aminotransferases

Abu Jhaisha,

Hohlstein,

Yagmur

et al. 2024

Diagnostics

Self Cite

View full text Add to dashboard Cite

Semaphorin 4D (Sema4D), also known as CD100, is a multifunctional transmembrane protein with immunoregulatory functions. Upon the activation of immune cells, soluble Semaphorin 4D (sSema4D) is proteolytically cleaved from the membrane by metalloproteinases. sSema4D levels are elevated in various (auto-)inflammatory diseases. Our aim was to investigate sSema4D levels in association with sepsis and critical illnesses and to evaluate sSema4D’s potential as a prognostic biomarker. We measured sSema4D levels in 192 patients upon admission to our medical intensive care unit. We found similar levels of sSema4D in 125 patients with sepsis compared to 67 non-septic patients. sSema4D levels correlated with leukocytes but not with other markers of systemic inflammation such as C-reactive protein or procalcitonin. Most interestingly, in a subgroup of patients suffering from pre-existing liver cirrhosis, we observed significantly higher levels of sSema4D. Consistently, sSema4D was also positively correlated with markers of hepatic and cholestatic injury. Our study suggests that sSema4D is not regulated in sepsis compared to other causes of critical illness. However, sSema4D seems to be associated with hepatic injury and inflammation.

show abstract

Clusterin Plasma Concentrations Are Decreased in Sepsis and Inversely Correlated with Established Markers of Inflammation

Cited by 6 publications

References 46 publications

Soluble Neuropilin-1 Is Elevated in Sepsis and Correlates with Organ Dysfunction and Long-Term Mortality in Critical Illness

Soluble Neuropilin-1 Is Elevated in Sepsis and Correlates with Organ Dysfunction and Long-Term Mortality in Critical Illness

Elevated Midkine Serum Levels Are Associated with Long-Term Survival in Critically Ill Patients

Soluble Semaphorin 4D Serum Concentrations Are Elevated in Critically Ill Patients with Liver Cirrhosis and Correlate with Aminotransferases

Contact Info

Product

Resources

About